ID Q5KVH3_GEOKA Unreviewed; 503 AA.
AC Q5KVH3;
DT 01-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 01-FEB-2005, sequence version 1.
DT 24-JAN-2024, entry version 104.
DE SubName: Full=5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase {ECO:0000313|EMBL:BAD77313.1};
GN OrderedLocusNames=GK3028 {ECO:0000313|EMBL:BAD77313.1};
OS Geobacillus kaustophilus (strain HTA426).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC Geobacillus thermoleovorans group.
OX NCBI_TaxID=235909 {ECO:0000313|EMBL:BAD77313.1, ECO:0000313|Proteomes:UP000001172};
RN [1] {ECO:0000313|EMBL:BAD77313.1, ECO:0000313|Proteomes:UP000001172}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HTA426 {ECO:0000313|EMBL:BAD77313.1,
RC ECO:0000313|Proteomes:UP000001172};
RX PubMed=15576355; DOI=10.1093/nar/gkh970;
RA Takami H., Takaki Y., Chee G.J., Nishi S., Shimamura S., Suzuki H.,
RA Matsui S., Uchiyama I.;
RT "Thermoadaptation trait revealed by the genome sequence of thermophilic
RT Geobacillus kaustophilus.";
RL Nucleic Acids Res. 32:6292-6303(2004).
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|RuleBase:RU003345}.
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DR EMBL; BA000043; BAD77313.1; -; Genomic_DNA.
DR RefSeq; WP_011232498.1; NC_006510.1.
DR AlphaFoldDB; Q5KVH3; -.
DR STRING; 235909.GK3028; -.
DR KEGG; gka:GK3028; -.
DR eggNOG; COG1012; Bacteria.
DR HOGENOM; CLU_005391_0_2_9; -.
DR OMA; EGGHYSF; -.
DR Proteomes; UP000001172; Chromosome.
DR GO; GO:0018480; F:5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity; IEA:InterPro.
DR GO; GO:1901023; P:4-hydroxyphenylacetate catabolic process; IEA:InterPro.
DR CDD; cd07093; ALDH_F8_HMSADH; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR011985; DH_HpaE.
DR NCBIfam; TIGR02299; HpaE; 1.
DR PANTHER; PTHR43720; 2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR43720:SF2; 2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000001172}.
FT DOMAIN 16..477
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 253
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 503 AA; 55192 MW; 840B49DACA91DB83 CRC64;
MAVQPKVLHY INGQFVEGAA GAYFDNINPF TNGTINQIAE GRKEDIDAAV RAAKEAFDHG
PWRTMPVERR LRYLFRIADL IEQYADDIAY LEALDTGIPI SQAKKQAARA AENFRFYAEM
VKTRLVGEAY HVNGQFLNYT VYKPVGVAGL ITPWNTPFML ETWKVAPALA TGNTVVLKPA
EWSPLTANKL AEIIDEAGLP RGVFNVVHGF GETAGAALVA HPDVRLISFT GETTTGMEII
RNSAATLKKT SMELGGKSPL IVFADADLER ALDAAVWGVF SLNGERCTAN SRLLLEQSIY
DEFVARLKER VDRIVIGDPM APATELGPLI HRAHWERVNR YIDIAKQEGA DVYAPSVPTG
LEKGNFVPPT LLLGCHNGMR VAQEEIFGPV MAVMSFADEE EAIRLANDVK YGLAAYVWTN
DMKRGHRVAQ AIESGMAWVN SPNVRDLRIP FGGTKYSGIG REGGHYSFDF YTEVQVVHVA
VGDPPIPSFG KAKPPSALSA EQK
//