ID Q5LCD3_BACFN Unreviewed; 812 AA.
AC Q5LCD3;
DT 21-JUN-2005, integrated into UniProtKB/TrEMBL.
DT 21-JUN-2005, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=BF9343_2451 {ECO:0000313|EMBL:CAH08232.1};
OS Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019
OS / NCTC 9343 / Onslow).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=272559 {ECO:0000313|EMBL:CAH08232.1, ECO:0000313|Proteomes:UP000006731};
RN [1] {ECO:0000313|EMBL:CAH08232.1, ECO:0000313|Proteomes:UP000006731}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 /
RC Onslow {ECO:0000313|Proteomes:UP000006731};
RX PubMed=15746427; DOI=10.1126/science.1107008;
RA Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V.,
RA Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A.,
RA Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A.,
RA Norbertczak H., Ormond D., Price C., Rabbinowitsch E., Woodward J.,
RA Barrell B.G., Parkhill J.;
RT "Extensive DNA inversions in the B. fragilis genome control variable gene
RT expression.";
RL Science 307:1463-1465(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CR626927; CAH08232.1; -; Genomic_DNA.
DR RefSeq; WP_010993046.1; NZ_UFTH01000001.1.
DR AlphaFoldDB; Q5LCD3; -.
DR PaxDb; 272559-BF9343_2451; -.
DR KEGG; bfs:BF9343_2451; -.
DR eggNOG; COG2203; Bacteria.
DR eggNOG; COG2205; Bacteria.
DR HOGENOM; CLU_000445_89_13_10; -.
DR BioCyc; BFRA272559:G1GHZ-2661-MONOMER; -.
DR Proteomes; UP000006731; Chromosome.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 3.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR43711:SF1; HISTIDINE KINASE 1; 1.
DR PANTHER; PTHR43711; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF08447; PAS_3; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50113; PAC; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:CAH08232.1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000006731};
KW Transferase {ECO:0000313|EMBL:CAH08232.1}.
FT DOMAIN 522..577
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 595..807
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 812 AA; 93125 MW; 07CC6FEBAE1D97CD CRC64;
MMISKNPLGD IAKLNRICAS AQIGWWEVNF TTGKCFISET LLKSLEVSSE WLDIDELMST
VRQDYRKRIT DEFTSIPRKG VFEQTFPVTS GRGNVFWIHC ALSMEEENEE GQLIATGYGQ
RIESPETQGY QCAWNQRINN LLYCQNSIAN SLLKLLSNDT GDELFEEMLA DILYFFKGAR
VYIVRYNWKN GNQSCLYEVA ACNVITLKEK LQNICSEDAP WFYQQIHANR PVILNSPDEL
PPLAVRDREV LAENGTNSMM LAPLMREEGV WGYMGIDIVD GYRKWNSEDY QWFSSLANII
SICMELRIIK ERVMHSEKLF HDIFTNIPVG LELYNKEGVL LDCNNRNLEI FGVGDKSRII
GLNLFESPNM TRDIHESLRA GRPGTFHLKY DFDEERRLFQ SERRGVMDLD IRSLMLYDAE
DNLSNYLLVN IDNTERNNAL SKVHDFENFF SIISDYSKVG YAKINLLDHT GFAVRQWYRN
LGESHDTPLA DIIGIFSHMH PDDRKSVLDF YEKAKAGTER FFDGDLRIRP ADGSDRWNWI
HKSSMVTAYQ SPNPRLELVE VNYDITVQKE TEAELRAARD KAEESNRLKS AFLANISHEI
RTPLNAIVGF SDLLMTVDDP AEQEEFRRTI QKNNTLLLQL FSDIIDLSKI DAGSFEYTPK
PVCLYQFCAM MVQKMRNKVS EGVELQIDED SPLDAWFSAD SGYLNQVVTN FMSNAIKFTH
RGTITVGYRI DARQQLEMFV EDTGIGISIE NQEAVFDRFM KVDSFVQGTG LGLPLCKSII
EKMGGHIGVI SELGKGSRFW FTLPAFSCIP TR
//
