ID Q5NDH4_AERJA Unreviewed; 371 AA.
AC Q5NDH4;
DT 01-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 01-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=DNA gyrase subunit B {ECO:0000256|ARBA:ARBA00019166};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
DE Flags: Fragment;
GN Name=gyrB {ECO:0000313|EMBL:CAI34889.1};
OS Aeromonas jandaei.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Aeromonadales;
OC Aeromonadaceae; Aeromonas.
OX NCBI_TaxID=650 {ECO:0000313|EMBL:CAI34889.1};
RN [1] {ECO:0000313|EMBL:CAI34889.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 49568T {ECO:0000313|EMBL:CAI34889.1};
RA Kupfer M., Kuhnert P., Korczak B.M., Peduzzi R., Demarta A.;
RT "Genetic relationships of Aeromonas strains inferred from 16S rRNA, gyrB
RT and rpoB gene sequences.";
RL Int. J. Syst. Evol. Microbiol. 56:2743-2751(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrB family.
CC {ECO:0000256|ARBA:ARBA00010708}.
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DR EMBL; AJ868391; CAI34889.1; -; Genomic_DNA.
DR AlphaFoldDB; Q5NDH4; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00822; TopoII_Trans_DNA_gyrase; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.670; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR001241; Topo_IIA.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR000565; Topo_IIA_B.
DR InterPro; IPR013759; Topo_IIA_B_C.
DR InterPro; IPR013506; Topo_IIA_bsu_dom2.
DR InterPro; IPR018522; TopoIIA_CS.
DR InterPro; IPR006171; TOPRIM_domain.
DR PANTHER; PTHR45866:SF1; DNA GYRASE SUBUNIT B, MITOCHONDRIAL; 1.
DR PANTHER; PTHR45866; DNA GYRASE/TOPOISOMERASE SUBUNIT B; 1.
DR Pfam; PF00204; DNA_gyraseB; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR01159; DNAGYRASEB.
DR SMART; SM00433; TOP2c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
DR PROSITE; PS00177; TOPOISOMERASE_II; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 302..371
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAI34889.1"
FT NON_TER 371
FT /evidence="ECO:0000313|EMBL:CAI34889.1"
SQ SEQUENCE 371 AA; 40915 MW; BDC0279AF038EC7C CRC64;
HGVGVSVVNA LSDKLLLTIR RNGHVYEQTY HLGEPQAPLK QIGDSTGTGT EVRFWPSPTI
FSDTLFHYEI LAKRLRELSF LNSGVSIRLM DERDGREAHF CYEGGIKAFV EYLNQNKTPI
HPKVFHFTTE QDGIGVEVAM QWNDAYQEGV YCFTNNIPQR DGGTHLVGFR TALTRTLNSY
MEKEDYSKKA KSAASGDDVR EGLIAVISVK VPDPKFSSQT KDKLVSSEVK TAVEQAMGEK
LADFLLENPG DAKIVVNKII DAARAREAAR KARELTRRKG ALDIAGLPGK LADCQEKDPA
LSELYIVEGD SAGGSAKQGR NRKNQAILPL KGKILNVEKA RFDKMISSQE VGTLITALGC
GIGRDEYNPD K
//
