ID SUCC_FRATT Reviewed; 387 AA.
AC Q5NHF3;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 01-MAY-2013, entry version 65.
DE RecName: Full=Succinyl-CoA ligase [ADP-forming] subunit beta;
DE EC=6.2.1.5;
DE AltName: Full=Succinyl-CoA synthetase subunit beta;
DE Short=SCS-beta;
GN Name=sucC; OrderedLocusNames=FTT_0504c;
OS Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC Francisellaceae; Francisella.
OX NCBI_TaxID=177416;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCHU S4 / Schu 4;
RX PubMed=15640799; DOI=10.1038/ng1499;
RA Larsson P., Oyston P.C.F., Chain P., Chu M.C., Duffield M.,
RA Fuxelius H.-H., Garcia E., Haelltorp G., Johansson D., Isherwood K.E.,
RA Karp P.D., Larsson E., Liu Y., Michell S., Prior J., Prior R.,
RA Malfatti S., Sjoestedt A., Svensson K., Thompson N., Vergez L.,
RA Wagg J.K., Wren B.W., Lindler L.E., Andersson S.G.E., Forsman M.,
RA Titball R.W.;
RT "The complete genome sequence of Francisella tularensis, the causative
RT agent of tularemia.";
RL Nat. Genet. 37:153-159(2005).
CC -!- CATALYTIC ACTIVITY: ATP + succinate + CoA = ADP + phosphate +
CC succinyl-CoA.
CC -!- COFACTOR: Binds 1 magnesium or manganese ion per subunit (By
CC similarity).
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC succinate from succinyl-CoA (ligase route): step 1/1.
CC -!- SUBUNIT: Heterotetramer of two alpha and two beta subunits (By
CC similarity).
CC -!- SIMILARITY: Belongs to the succinate/malate CoA ligase beta
CC subunit family.
CC -!- SIMILARITY: Contains 1 ATP-grasp domain.
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DR EMBL; AJ749949; CAG45137.1; -; Genomic_DNA.
DR RefSeq; YP_169539.1; NC_006570.2.
DR HSSP; P0A836; 2SCU.
DR ProteinModelPortal; Q5NHF3; -.
DR STRING; 177416.FTT_0504c; -.
DR EnsemblBacteria; CAG45137; CAG45137; FTT_0504c.
DR GeneID; 3190738; -.
DR KEGG; ftu:FTT_0504c; -.
DR eggNOG; COG0045; -.
DR HOGENOM; HOG000007059; -.
DR KO; K01903; -.
DR OMA; QPVTKIL; -.
DR ProtClustDB; PRK00696; -.
DR UniPathway; UPA00223; UER00999.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR GO; GO:0030145; F:manganese ion binding; IEA:HAMAP.
DR GO; GO:0004775; F:succinate-CoA ligase (ADP-forming) activity; IEA:HAMAP.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:HAMAP.
DR Gene3D; 3.30.1490.20; -; 1.
DR Gene3D; 3.30.470.20; -; 1.
DR Gene3D; 3.40.50.261; -; 1.
DR HAMAP; MF_00558; Succ_CoA_beta; 1; -.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013650; ATP-grasp_succ-CoA_synth-type.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR013816; ATP_grasp_subdomain_2.
DR InterPro; IPR005811; CoA_ligase.
DR InterPro; IPR017866; Succ-CoA_synthase_bsu_CS.
DR InterPro; IPR005809; Succ_CoA_synthase_bsu.
DR InterPro; IPR016102; Succinyl-CoA_synth-like.
DR PANTHER; PTHR11815; PTHR11815; 1.
DR Pfam; PF08442; ATP-grasp_2; 1.
DR Pfam; PF00549; Ligase_CoA; 1.
DR PIRSF; PIRSF001554; SucCS_beta; 1.
DR SUPFAM; SSF52210; CoA_ligase; 1.
DR TIGRFAMs; TIGR01016; sucCoAbeta; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS01217; SUCCINYL_COA_LIG_3; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Ligase; Magnesium; Manganese;
KW Metal-binding; Nucleotide-binding; Reference proteome;
KW Tricarboxylic acid cycle.
FT CHAIN 1 387 Succinyl-CoA ligase [ADP-forming] subunit
FT beta.
FT /FTId=PRO_1000082093.
FT DOMAIN 9 245 ATP-grasp.
FT NP_BIND 35 109 ATP (By similarity).
FT METAL 198 198 Magnesium or manganese (By similarity).
FT METAL 200 200 Magnesium or manganese (By similarity).
SQ SEQUENCE 387 AA; 41542 MW; 919784198896DE32 CRC64;
MNLHEYQAKD LLESYGLKVQ KGIVAHNPNE AAQAFDQLGG KFAVVKAQVH AGGRGKAGGV
KVVKSSQEAR EVAESLIGKN LVTFQTDAEG QPVNSVGVFE DVYPVTRELY LGAVVDRSSR
KVTFMASTEG GVDIEEVAHN SPEKILKVEV DPLVGLQPFQ AREVAFKLGL EGKQINDFVK
TMLGAYKAFI ECDFALFEIN PLAVRENGEI VCVDGKINLD SNALYRHPKL LALRDKSQEN
AKELKASEHE LNYVALEGNI GCMVNGAGLA MATMDIIQLY GGKPANFLDV GGGATKERVI
EAFKLILDDE NVKAILINIF GGIVRCDMIA EAIIEAVKEV NVTVPVVVRL EGNNAEKGAK
ILADSGLKLI PADGLADAAD KVVKSLG
//
