ID Q5NUU7_CUPMC Unreviewed; 144 AA.
AC Q5NUU7;
DT 04-JAN-2005, integrated into UniProtKB/TrEMBL.
DT 04-JAN-2005, sequence version 1.
DT 27-MAR-2024, entry version 131.
DE RecName: Full=Mercuric resistance operon regulatory protein {ECO:0000256|ARBA:ARBA00017146};
GN Name=merR {ECO:0000313|EMBL:ABF13030.1};
GN OrderedLocusNames=Rmet_6171 {ECO:0000313|EMBL:ABF13030.1};
OS Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 /
OS CH34) (Ralstonia metallidurans).
OG Plasmid pMOL30 {ECO:0000313|EMBL:ABF13030.1,
OG ECO:0000313|Proteomes:UP000002429}.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=266264 {ECO:0000313|EMBL:ABF13030.1, ECO:0000313|Proteomes:UP000002429};
RN [1] {ECO:0000313|Proteomes:UP000002429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43123 / DSM 2839 / NBRC 102507 / CH34
RC {ECO:0000313|Proteomes:UP000002429};
RC PLASMID=Plasmid pMOL30 {ECO:0000313|Proteomes:UP000002429};
RX PubMed=20463976; DOI=10.1371/journal.pone.0010433;
RA Janssen P.J., Van Houdt R., Moors H., Monsieurs P., Morin N., Michaux A.,
RA Benotmane M.A., Leys N., Vallaeys T., Lapidus A., Monchy S., Medigue C.,
RA Taghavi S., McCorkle S., Dunn J., van der Lelie D., Mergeay M.;
RT "The complete genome sequence of Cupriavidus metallidurans strain CH34, a
RT master survivalist in harsh and anthropogenic environments.";
RL PLoS ONE 5:E10433-E10433(2010).
CC -!- FUNCTION: Mediates the mercuric-dependent induction of mercury
CC resistance operon. In the absence of mercury MerR represses
CC transcription by binding tightly to the mer operator region; when
CC mercury is present the dimeric complex binds a single ion and becomes a
CC potent transcriptional activator, while remaining bound to the mer
CC site. {ECO:0000256|ARBA:ARBA00024874}.
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DR EMBL; CP000354; ABF13030.1; -; Genomic_DNA.
DR RefSeq; WP_003131969.1; NC_007972.2.
DR RefSeq; YP_145639.1; NC_006466.1.
DR RefSeq; YP_161730.1; NC_006525.1.
DR AlphaFoldDB; Q5NUU7; -.
DR SMR; Q5NUU7; -.
DR GeneID; 84813686; -.
DR KEGG; rme:Rmet_6171; -.
DR HOGENOM; CLU_060077_2_0_4; -.
DR Proteomes; UP000002429; Plasmid pMOL30.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0045340; F:mercury ion binding; IEA:InterPro.
DR GO; GO:0046689; P:response to mercury ion; IEA:UniProtKB-KW.
DR CDD; cd04783; HTH_MerR1; 1.
DR Gene3D; 1.10.1660.10; -; 1.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR011794; MerR.
DR InterPro; IPR000551; MerR-type_HTH_dom.
DR InterPro; IPR047057; MerR_fam.
DR InterPro; IPR015358; Tscrpt_reg_MerR_DNA-bd.
DR NCBIfam; TIGR02051; MerR; 1.
DR PANTHER; PTHR30204:SF67; HTH-TYPE TRANSCRIPTIONAL REGULATOR MLRA-RELATED; 1.
DR PANTHER; PTHR30204; REDOX-CYCLING DRUG-SENSING TRANSCRIPTIONAL ACTIVATOR SOXR; 1.
DR Pfam; PF00376; MerR; 1.
DR Pfam; PF09278; MerR-DNA-bind; 1.
DR PRINTS; PR00040; HTHMERR.
DR SMART; SM00422; HTH_MERR; 1.
DR SUPFAM; SSF46955; Putative DNA-binding domain; 1.
DR PROSITE; PS00552; HTH_MERR_1; 1.
DR PROSITE; PS50937; HTH_MERR_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Mercuric resistance {ECO:0000256|ARBA:ARBA00022466};
KW Mercury {ECO:0000256|ARBA:ARBA00022914};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Plasmid {ECO:0000313|EMBL:ABF13030.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002429};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 7..76
FT /note="HTH merR-type"
FT /evidence="ECO:0000259|PROSITE:PS50937"
SQ SEQUENCE 144 AA; 15763 MW; C573298AFF0846EF CRC64;
MENNLENLTI GVFAKAAGVN VETIRFYQRK GLLLEPDKPY GSIRRYGEAD VTRVRFVKSA
QRLGFSLDEI AELLRLEDGT HCEEASSLAE HKLKDVREKM ADLARMEAVL SELVCACHAR
RGNVSCPLIA SLQGGASLAG SAMP
//
