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Database: UniProt
Entry: Q5PR66
LinkDB: Q5PR66
Original site: Q5PR66 
ID   TTC26_DANRE             Reviewed;         557 AA.
AC   Q5PR66;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   19-FEB-2014, entry version 63.
DE   RecName: Full=Tetratricopeptide repeat protein 26;
DE            Short=TPR repeat protein 26;
GN   Name=ttc26; ORFNames=zgc:103412;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=22718903; DOI=10.1091/mbc.E12-01-0019;
RA   Zhang Q., Liu Q., Austin C., Drummond I., Pierce E.A.;
RT   "Knockdown of ttc26 disrupts ciliogenesis of the photoreceptor cells
RT   and the pronephros in zebrafish.";
RL   Mol. Biol. Cell 23:3069-3078(2012).
CC   -!- FUNCTION: Requires for ciliogenesis and normal cilia function.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium (By similarity).
CC   -!- DISRUPTION PHENOTYPE: Morpholino knockdown of the protein results
CC       in cilia defects in the pronephric kidney at 27 hpf and
CC       distension/dilation of pronephros at 5 dpf. In the eyes, the outer
CC       segments of photoreceptor cells appear shortened or absent,
CC       whereas cellular lamination seems normal in retinas at 5 dpf.
CC   -!- SIMILARITY: Contains 4 TPR repeats.
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DR   EMBL; BC086810; AAH86810.1; -; mRNA.
DR   RefSeq; NP_001008617.1; NM_001008617.1.
DR   UniGene; Dr.14525; -.
DR   ProteinModelPortal; Q5PR66; -.
DR   STRING; 7955.ENSDARP00000032176; -.
DR   GeneID; 494074; -.
DR   KEGG; dre:494074; -.
DR   CTD; 79989; -.
DR   ZFIN; ZDB-GENE-041212-41; ttc26.
DR   eggNOG; NOG297868; -.
DR   HOGENOM; HOG000258854; -.
DR   HOVERGEN; HBG108610; -.
DR   InParanoid; Q5PR66; -.
DR   NextBio; 20865582; -.
DR   PRO; PR:Q5PR66; -.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0042384; P:cilium assembly; IMP:UniProtKB.
DR   GO; GO:0008594; P:photoreceptor cell morphogenesis; IDA:MGI.
DR   GO; GO:0035845; P:photoreceptor cell outer segment organization; IMP:ZFIN.
DR   GO; GO:0039023; P:pronephric duct morphogenesis; IMP:ZFIN.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR013026; TPR-contain_dom.
DR   InterPro; IPR011990; TPR-like_helical.
DR   InterPro; IPR019734; TPR_repeat.
DR   SMART; SM00028; TPR; 3.
DR   PROSITE; PS50293; TPR_REGION; 2.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation;
KW   Complete proteome; Reference proteome; Repeat; TPR repeat.
FT   CHAIN         1    557       Tetratricopeptide repeat protein 26.
FT                                /FTId=PRO_0000289086.
FT   REPEAT       60     93       TPR 1.
FT   REPEAT       95    128       TPR 2.
FT   REPEAT      154    187       TPR 3.
FT   REPEAT      471    504       TPR 4.
SQ   SEQUENCE   557 AA;  64114 MW;  98522C226D5095BF CRC64;
     MLLSRMKPAV GGEASTSSNE KKRKNKSKKI PRLEDYLNQR DYLGALTLLE FQRNSGVSVE
     HADLWTGFCA FHVGDHKRAM EEYKALTLRP DCPVDVWVYL GCALFFLGLY KEAEEAALKG
     SKTQLQNRLL FHLAHKFNDE KKLMGFHQNL EDVTEDQLSL ASIHYMRSHY QEAIDIYKRI
     LLQNREFLAL NVYVALCYYK LDYYDVSQEV LAVYLQSIPD STIALNLKAC NHFRLYNGKA
     AETELKNLID ISSSSFQFAK ELIQHNLVVF RGGGGALQVL PPLIDVISEA RLNLVIYYLR
     QDDIQEAYKL IKDLEPTTPQ EYILKGVVNA ALGQEIGSRD HLKIAQQFFQ LVGGSASECD
     TIPGRQCMAS CFFLLKQFED VLIYLNSVKS YFYNDDTFSF NYAQAKAALG NYREAEELFL
     LIQNEKIKSD YVFQSWLARC YIMNQKPRQA WELYLRMETS SDPFSLLQLI ANDCYKMGQF
     YYAAKAFDAL ERLDPNPEYW EGKRGACVGI FQLILAGRES REILKEVLPM LRSTGNPQVE
     YIIRIMKKWA KDNRVAL
//
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