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Database: UniProt
Entry: Q5PR66
LinkDB: Q5PR66
Original site: Q5PR66 
ID   IFT56_DANRE             Reviewed;         557 AA.
AC   Q5PR66; F1QZ19;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-JAN-2015, sequence version 2.
DT   04-FEB-2015, entry version 68.
DE   RecName: Full=Intraflagellar transport protein 56 {ECO:0000303|PubMed:24596149};
DE   AltName: Full=Tetratricopeptide repeat protein 26;
DE            Short=TPR repeat protein 26;
GN   Name=ttc26; Synonyms=ift56 {ECO:0000303|PubMed:24596149};
GN   ORFNames=zgc:103412;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G.,
RA   Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B.,
RA   Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S.,
RA   Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C.,
RA   Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H.,
RA   Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C.,
RA   Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J.,
RA   Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S.,
RA   Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R.,
RA   Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R.,
RA   Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R.,
RA   Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A.,
RA   Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S.,
RA   Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=22718903; DOI=10.1091/mbc.E12-01-0019;
RA   Zhang Q., Liu Q., Austin C., Drummond I., Pierce E.A.;
RT   "Knockdown of ttc26 disrupts ciliogenesis of the photoreceptor cells
RT   and the pronephros in zebrafish.";
RL   Mol. Biol. Cell 23:3069-3078(2012).
RN   [4]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=24596149; DOI=10.7554/eLife.01566;
RA   Ishikawa H., Ide T., Yagi T., Jiang X., Hirono M., Sasaki H.,
RA   Yanagisawa H., Wemmer K.A., Stainier D.Y., Qin H., Kamiya R.,
RA   Marshall W.F.;
RT   "TTC26/DYF13 is an intraflagellar transport protein required for
RT   transport of motility-related proteins into flagella.";
RL   Elife 3:E01566-E01566(2014).
RN   [5]
RP   ERRATUM.
RX   PubMed=24692455; DOI=10.7554/eLife.02897;
RA   Ishikawa H., Ide T., Yagi T., Jiang X., Hirono M., Sasaki H.,
RA   Yanagisawa H., Wemmer K.A., Stainier D.Y., Qin H., Kamiya R.,
RA   Marshall W.F.;
RL   Elife 3:E02897-E02897(2014).
CC   -!- FUNCTION: Component of the intraflagellar transport (IFT) complex
CC       B required for transport of proteins in the motile cilium.
CC       Required for transport of specific ciliary cargo proteins related
CC       to motility, while it is neither required for IFT complex B
CC       assembly or motion nor for cilium assembly.
CC       {ECO:0000269|PubMed:22718903, ECO:0000305|PubMed:24596149}.
CC   -!- SUBUNIT: Component of the IFT complex B.
CC       {ECO:0000250|UniProtKB:Q8BS45}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q8BS45}.
CC   -!- DISRUPTION PHENOTYPE: Defective cilia (PubMed:22718903,
CC       PubMed:24596149). Morpholino knockdown of the protein results in
CC       cilia defects in the pronephric kidney at 27 hpf and
CC       distension/dilation of pronephros at 5 dpf. In the eyes, the outer
CC       segments of photoreceptor cells appear shortened or absent,
CC       whereas cellular lamination seems normal in retinas at 5 dpf
CC       (PubMed:22718903). Left-right asymmetry defects with abnormal
CC       heart looping, hydrocephalus, pronephric cysts, abnormal ear
CC       otolith formation and curly body axis (PubMed:24596149).
CC       {ECO:0000269|PubMed:22718903, ECO:0000269|PubMed:24596149}.
CC   -!- SIMILARITY: Belongs to the IFT56 family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 4 TPR repeats. {ECO:0000305}.
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DR   EMBL; AL954384; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC086810; AAH86810.1; -; mRNA.
DR   RefSeq; NP_001008617.1; NM_001008617.1.
DR   UniGene; Dr.14525; -.
DR   ProteinModelPortal; Q5PR66; -.
DR   STRING; 7955.ENSDARP00000032176; -.
DR   GeneID; 494074; -.
DR   KEGG; dre:494074; -.
DR   CTD; 79989; -.
DR   ZFIN; ZDB-GENE-041212-41; ttc26.
DR   eggNOG; NOG297868; -.
DR   HOGENOM; HOG000258854; -.
DR   HOVERGEN; HBG108610; -.
DR   InParanoid; Q5PR66; -.
DR   PhylomeDB; Q5PR66; -.
DR   NextBio; 20865582; -.
DR   PRO; PR:Q5PR66; -.
DR   Proteomes; UP000000437; Unplaced.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0030992; C:intraciliary transport particle B; ISS:UniProtKB.
DR   GO; GO:0042384; P:cilium assembly; IMP:UniProtKB.
DR   GO; GO:0042073; P:intraciliary transport; IMP:UniProtKB.
DR   GO; GO:0046530; P:photoreceptor cell differentiation; IDA:MGI.
DR   GO; GO:0008594; P:photoreceptor cell morphogenesis; IDA:MGI.
DR   GO; GO:0035845; P:photoreceptor cell outer segment organization; IMP:ZFIN.
DR   GO; GO:0039023; P:pronephric duct morphogenesis; IMP:ZFIN.
DR   GO; GO:0007224; P:smoothened signaling pathway; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR013026; TPR-contain_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom.
DR   InterPro; IPR019734; TPR_repeat.
DR   SMART; SM00028; TPR; 3.
DR   PROSITE; PS50293; TPR_REGION; 2.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Complete proteome; Protein transport;
KW   Reference proteome; Repeat; TPR repeat; Transport.
FT   CHAIN         1    557       Intraflagellar transport protein 56.
FT                                /FTId=PRO_0000289086.
FT   REPEAT       60     93       TPR 1.
FT   REPEAT       95    128       TPR 2.
FT   REPEAT      154    187       TPR 3.
FT   REPEAT      471    504       TPR 4.
FT   CONFLICT    274    274       E -> G (in Ref. 2; AAH86810).
SQ   SEQUENCE   557 AA;  64186 MW;  DCED6622EFF8BFBE CRC64;
     MLLSRMKPAV GGEASTSSNE KKRKNKSKKI PRLEDYLNQR DYLGALTLLE FQRNSGVSVE
     HADLWTGFCA FHVGDHKRAM EEYKALTLRP DCPVDVWVYL GCALFFLGLY KEAEEAALKG
     SKTQLQNRLL FHLAHKFNDE KKLMGFHQNL EDVTEDQLSL ASIHYMRSHY QEAIDIYKRI
     LLQNREFLAL NVYVALCYYK LDYYDVSQEV LAVYLQSIPD STIALNLKAC NHFRLYNGKA
     AETELKNLID ISSSSFQFAK ELIQHNLVVF RGGEGALQVL PPLIDVISEA RLNLVIYYLR
     QDDIQEAYKL IKDLEPTTPQ EYILKGVVNA ALGQEIGSRD HLKIAQQFFQ LVGGSASECD
     TIPGRQCMAS CFFLLKQFED VLIYLNSVKS YFYNDDTFSF NYAQAKAALG NYREAEELFL
     LIQNEKIKSD YVFQSWLARC YIMNQKPRQA WELYLRMETS SDPFSLLQLI ANDCYKMGQF
     YYAAKAFDAL ERLDPNPEYW EGKRGACVGI FQLILAGRES REILKEVLPM LRSTGNPQVE
     YIIRIMKKWA KDNRVAL
//
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