ID Q5QGN4_DANRE Unreviewed; 355 AA.
AC Q5QGN4;
DT 04-JAN-2005, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 2.
DT 27-MAR-2024, entry version 93.
DE SubName: Full=Hepatocellular carcinoma-related putative tumor suppressor LPTS {ECO:0000313|EMBL:AAT80626.2};
DE SubName: Full=PIN2/TERF1-interacting telomerase inhibitor 1 {ECO:0000313|RefSeq:NP_001013283.2};
GN Name=pinx1 {ECO:0000313|RefSeq:NP_001013283.2,
GN ECO:0000313|ZFIN:ZDB-GENE-030515-2};
GN Synonyms=zLPTS {ECO:0000313|RefSeq:NP_001013283.2};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAT80626.2};
RN [1] {ECO:0000313|EMBL:AAT80626.2, ECO:0000313|RefSeq:NP_001013283.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18583067; DOI=10.1016/j.gene.2008.05.013;
RA Sun C., Wu Z., Jia F., Wang Y., Li T., Zhao M.;
RT "Identification of zebrafish LPTS: a gene with similarities to human
RT LPTS/PinX1 that inhibits telomerase activity.";
RL Gene 420:90-98(2008).
RN [2] {ECO:0000313|RefSeq:NP_001013283.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20828405;
RA Mueller R.L., Huang C., Ho R.K.;
RT "Spatio-temporal regulation of Wnt and retinoic acid signaling by
RT tbx16/spadetail during zebrafish mesoderm differentiation.";
RL BMC Genomics 11:492-492(2010).
RN [3] {ECO:0000313|RefSeq:NP_001013283.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21114664;
RA Danilova N., Sakamoto K.M., Lin S.;
RT "Ribosomal protein L11 mutation in zebrafish leads to haematopoietic and
RT metabolic defects.";
RL Br. J. Haematol. 152:217-228(2011).
RN [4] {ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|RefSeq:NP_001013283.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [6] {ECO:0000313|RefSeq:NP_001013283.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY576808; AAT80626.2; -; mRNA.
DR RefSeq; NP_001013283.2; NM_001013265.2.
DR GeneID; 368253; -.
DR KEGG; dre:368253; -.
DR AGR; ZFIN:ZDB-GENE-030515-2; -.
DR CTD; 54984; -.
DR ZFIN; ZDB-GENE-030515-2; pinx1.
DR OrthoDB; 2919396at2759; -.
DR Proteomes; UP000000437; Chromosome 20.
DR GO; GO:0005730; C:nucleolus; IDA:ZFIN.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0010521; F:telomerase inhibitor activity; IDA:ZFIN.
DR InterPro; IPR000467; G_patch_dom.
DR PANTHER; PTHR23149; G PATCH DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23149:SF27; PIN2_TERF1-INTERACTING TELOMERASE INHIBITOR 1; 1.
DR Pfam; PF01585; G-patch; 1.
DR SMART; SM00443; G_patch; 1.
DR PROSITE; PS50174; G_PATCH; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 26..72
FT /note="G-patch"
FT /evidence="ECO:0000259|PROSITE:PS50174"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..319
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..348
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 355 AA; 40565 MW; 09ABDCBB959442AE CRC64;
MSMLAEPRRK QKWSVDPRNS AWSNDESKFG QKMLERMGWS KGKGLGKTEQ GSTEHIKVKV
KNNSLGLGTA VNHEDNWIAH QDDFNQLLAD LNNCHGQNNT ENPTQDKGFS LEEKSKTSKK
RVHYMKFTKG KDLSSRSETD LACIFGKRAK QETKDQDEGS SGSDSQEDKE DSETLAYPEI
QPNTVTSSLT MQEYFAQRMA LLKRTNTATS APSTPASTED STPNASDAEQ TKKKRKKKKD
RERNRDAAEE DMQTRVTGES VEEPQNHSQK KKKKKKSRRN EEDEVNGAST VMEEEESREQ
VEADEQPTVE IENQDSKVSE KKKKKKKKRE QDDGEKEEEV TEEMIPKQKK KKQKK
//
