ID Q5R4G1_PONAB Unreviewed; 827 AA.
AC Q5R4G1;
DT 21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 21-DEC-2004, sequence version 1.
DT 24-JAN-2024, entry version 116.
DE RecName: Full=Hypoxia-inducible factor 1-alpha {ECO:0000256|ARBA:ARBA00014446};
GN Name=DKFZp459N173 {ECO:0000313|EMBL:CAH93355.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|EMBL:CAH93355.1};
RN [1] {ECO:0000313|EMBL:CAH93355.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Cortex {ECO:0000313|EMBL:CAH93355.1};
RG The German cDNA Consortium;
RA Wambutt R., Heubner D., Mewes H.W., Weil B., Amid C., Osanger A., Fobo G.,
RA Han M., Wiemann S.;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
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DR EMBL; CR861288; CAH93355.1; -; mRNA.
DR RefSeq; NP_001126975.1; NM_001133503.1.
DR AlphaFoldDB; Q5R4G1; -.
DR GeneID; 100173994; -.
DR KEGG; pon:100173994; -.
DR CTD; 3091; -.
DR OrthoDB; 5396877at2759; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0001666; P:response to hypoxia; IEA:UniProt.
DR CDD; cd19727; bHLH-PAS_HIF1a_PASD8; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR001321; HIF-1_alpha.
DR InterPro; IPR014887; HIF-1_CTAD.
DR InterPro; IPR021537; HIF_alpha-like.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR013655; PAS_fold_3.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR PANTHER; PTHR23043:SF7; HYPOXIA-INDUCIBLE FACTOR 1-ALPHA; 1.
DR Pfam; PF11413; HIF-1; 1.
DR Pfam; PF08778; HIF-1a_CTAD; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF08447; PAS_3; 1.
DR PRINTS; PR01080; HYPOXIAIF1A.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 2: Evidence at transcript level;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 18..71
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 94..149
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 248..299
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 643..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 646..671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 403
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
FT MOD_RES 565
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
FT MOD_RES 804
FT /note="(3S)-3-hydroxyasparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
SQ SEQUENCE 827 AA; 92821 MW; B64FB01E8EFCE232 CRC64;
MEGAGGANDK KNRISSERRK EKSRDAARSR RSKESEVFYE LAHQLPLPHN VSSHLDKASV
MRLTISYLRV RKLLDAGDLD IEDEMKAQMN CFYLKALDGF VMVLTDDGDM IYISDNVNKY
MGLTQFELTG HSVFDFTHPC DHEEMREMLT HRNGPVKKGK EQNTQRSFFL RMKCTLTSRG
RTMNIKSATW KVLHCTGHIH VYDTNSNQPQ CGYKKPPMTC LVLICEPIPH PSNIEIPLDS
KTFLSRHSLD MKFSYCDERI TELMGYEPEE LLGRSIYEYY HALDSDHLTK THHDMFTKGQ
VTTGQYRMLA KRGGYVWVET QATVIYNTKN SQPQCIVCVN YVVSGIIQHD LIFSLQQTEC
VLKPVESSDM KMTQLFTKVE SEDTSSLFDK LKKEPDALTL LAPAAGDTII SLDFGSNDTE
TDDQQLEEVP LYNDVMLPSP NEKLQNINLA MSPLPTAETP KPLRSSADPA LNQEVALKLE
PNPESLELSF TMPQIQDQPP SPSDGSTRQS SPEPNSPSEY CFYVDSDMVN EFKLELVEKL
FAEDTEAKNP FSTQDTDLDL EMLAPYIPMD DDFQLRSFDQ LSPLESSSAS PESASPQSTV
TVFQQTQIQE PTANATTTTA TTDELKTVTK DRMEDIKILI ASPSPTHIHK ETTSATSSPY
RDTQSRTASP NRAGKGVIEQ TEKSHPRSPN VLSVALSQRT TVPEEELNPK ILALQNAQRK
RKMEHDGSLF QAVGIGTLLQ QPEDHAATTS LSWKRVKGCK SSEQNGMEQK TIILIPSDLA
CRLLGQSMDE SGLPQLTSYD CEVNAPIQGS RNLLQGEELL RALDQVN
//
