ID Q5RAR2_PONAB Unreviewed; 876 AA.
AC Q5RAR2;
DT 21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 21-DEC-2004, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN Name=DKFZp469P0923 {ECO:0000313|EMBL:CAH91148.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|EMBL:CAH91148.1};
RN [1] {ECO:0000313|EMBL:CAH91148.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Kidney {ECO:0000313|EMBL:CAH91148.1};
RG The German cDNA Consortium;
RA Ansorge W., Krieger S., Regiert T., Rittmueller C., Schwager B.,
RA Mewes H.W., Weil B., Amid C., Osanger A., Fobo G., Han M., Wiemann S.;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR858950; CAH91148.1; -; mRNA.
DR RefSeq; NP_001125671.1; NM_001132199.2.
DR AlphaFoldDB; Q5RAR2; -.
DR GeneID; 100172591; -.
DR KEGG; pon:100172591; -.
DR CTD; 114882; -.
DR OrthoDB; 1018068at2759; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13286; PH_OPR5_ORP8; 1.
DR Gene3D; 1.10.287.2720; -; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF218; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 8; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT TRANSMEM 858..875
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 135..252
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..357
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..778
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 788..802
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 876 AA; 99920 MW; 4D2E3C44504625F0 CRC64;
MLLGDSKDVL GPSTVVANSD ESQLLTPGKM SQRQGKEAYP TPTKDLHQPS LSPASPHSRG
FERGKEDISQ NKDESSLSMS KSKSESKLYN GSEKDSSTSS KLTKKESLKV QKKNYREEKK
RATKELLSTI TDPSVIVMAD WLKIRGTLKS WTKLWCVLKP GVLLIYKTQK NGQWVGTVLL
NACEIIERPS KKDGFCFKLF HPLEQSIWAV KGPKGEAVGS ITQPLPSSYL IIRATSESDG
RCWMDALELA LKCSSLLKRT MIREGKEHDL SVSSDSTHVT FYGLLRANNL HSGDNFQLND
SEIERQHFKD QDMYSDKSDK ENDQEHDESD NEVMGKSEES DTDTSERQDD SYIEPEPVEP
LKETTYTEQS HEELGEAGEA SQTETVSEEN KSLIWTLLKQ VRPGMDLSKV VLPTFILEPR
SFLDKLSDYY YHADFLSEAA LEENPYFRLK KVVKWYLSGF YKKPKGLKKP YNPILGETFR
CLWIHPRTNS KTFYIAEQVS HHPPISAFYV SNRKDGFCLS GSILAKSKFY GNSLSAILEG
EARLTFLNRG EDYVMTMPYA HCKGILYGTM TLELGGTVNI TCQKTGYSAI LEFKLKPFLG
SSDCVNQISG KLKLGKEVLA TLEGHWDSEV FITDKKTDNS EVFWNPTPDI KQWRLIRHTV
KFEEQGDFES EKLWQRVTRA INAKDQTEAT QEKYVLEEAQ RQAARDRKIK NEEWSCKLFE
LDPLTGEWHY KFADTRPWDP LNDMIQFEKD GVIQTKVKHR TPMVSVPKMK HKPTRQQKKV
AKGYSSPEPD IQDSSGSEAQ SVKPSTRRKK GIELGDIQSS IESIKQTQEE IKRNIMALRN
HLVSSTPAAD YFLQQKDYFI IFLLILLQVI INFMFK
//
