ID WDR48_PONAB Reviewed; 677 AA.
AC Q5RAW8;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 29-MAY-2013, entry version 62.
DE RecName: Full=WD repeat-containing protein 48;
DE AltName: Full=USP1-associated factor 1;
GN Name=WDR48; Synonyms=UAF1;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulator of deubiquitinating complexes. Acts as a
CC strong activator of USP1 by enhancing the USP1-mediated
CC deubiquitination of FANCD2; USP1 being almost inactive by itself.
CC Also activates deubiquitinating activity of complexes containing
CC USP12 and USP46, respectively. Activates deubiquitination by
CC increasing the catalytic turnover without increasing the affinity
CC of deubiquitinating enzymes for the substrate. May play a role in
CC vesicular transport or membrane fusion events necessary for
CC transport to lysosomes (By similarity).
CC -!- SUBUNIT: Interacts with USP1, USP12 and USP46 (By similarity).
CC -!- SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By
CC similarity). Lysosome (By similarity).
CC -!- DOMAIN: The WD repeats are required for the interaction with
CC deubiquitinating enzymes USP1, USP12 and USP46 (By similarity).
CC -!- SIMILARITY: Belongs to the WD repeat WDR48 family.
CC -!- SIMILARITY: Contains 8 WD repeats.
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DR EMBL; CR858893; CAH91092.1; -; mRNA.
DR RefSeq; NP_001125636.1; NM_001132164.2.
DR ProteinModelPortal; Q5RAW8; -.
DR Ensembl; ENSPPYT00000016282; ENSPPYP00000015661; ENSPPYG00000014001.
DR GeneID; 100172554; -.
DR KEGG; pon:100172554; -.
DR CTD; 57599; -.
DR GeneTree; ENSGT00520000055738; -.
DR HOVERGEN; HBG079413; -.
DR InParanoid; Q5RAW8; -.
DR KO; K15361; -.
DR OMA; NRLYSAG; -.
DR OrthoDB; EOG4HHP1W; -.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0016579; P:protein deubiquitination; ISS:UniProtKB.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR021772; DUF3337.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR017986; WD40_repeat_dom.
DR Pfam; PF11816; DUF3337; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40_like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Complete proteome; Cytoplasm; Lysosome; Nucleus;
KW Phosphoprotein; Reference proteome; Repeat; Ubl conjugation pathway;
KW WD repeat.
FT CHAIN 1 677 WD repeat-containing protein 48.
FT /FTId=PRO_0000051402.
FT REPEAT 28 67 WD 1.
FT REPEAT 73 112 WD 2.
FT REPEAT 115 154 WD 3.
FT REPEAT 166 205 WD 4.
FT REPEAT 208 247 WD 5.
FT REPEAT 250 289 WD 6.
FT REPEAT 292 334 WD 7.
FT REPEAT 358 452 WD 8.
FT MOD_RES 28 28 Phosphotyrosine (By similarity).
FT MOD_RES 214 214 N6-acetyllysine (By similarity).
FT MOD_RES 338 338 Phosphotyrosine (By similarity).
SQ SEQUENCE 677 AA; 76223 MW; 3A5E28880EC4883D CRC64;
MAAHHRQNTA GRRKVQVSYV IRDEVEKYNR NGVNALQLDP ALNRLFTAGR DSIIRIWSVN
QHKQDPYIAS MEHHTDWVND IVLCCNGKTL ISASSDTTVK VWNAHKGFCM STLRTHKDYV
KALAYAKDKE LVASAGLDRQ IFLWDVNTLT ALTASNNTVT TSSLSGNKDS IYSLAMNQLG
TIIVSGSTEK VLRVWDPRTC AKLMKLKGHT DNVKALLLNR DGTQCLSGSS DGTIRLWSLG
QQRCIATYRV HDEGVWALQV NDAFTHVYSG GRDRKIYCTD LRNPDIRVLI CEEKAPVLKM
ELDRSADPPP AIWVATTKST VNKWILKGIH NFRASGDYDN DCTNPITPLC TQPDQVIKGG
ASIIQCHILN DKRHILTKDT NNNVAYWDVL KACKVEDLGK VDFEDEIKKR FKMVYVPNWF
SVDLKTGMLT ITLDESDCFA AWVSAKDAGF SSPDGSDPKL NLGGLLLQAL LEYWPRTHVN
PMDEEENEVN HVNGEQENRV QKGNGYFQVP PHTPVIFGEA GGRTLFRLLC RDSGGETESM
LLNETVPQWV IDITVDKNMP KFNKIPFYLQ PHASSGAKTL KKDRLSASDM LQVRKVMEHV
YEKIINLDNE SQTTSSSNNE KPGEQEKEED IAVLAEEKIE LLCQDQVLDP NMDLRTVKHF
IWKSGGDLTL HYRQKST
//
