GenomeNet

Database: UniProt
Entry: Q5RAW8
LinkDB: Q5RAW8
Original site: Q5RAW8 
ID   WDR48_PONAB             Reviewed;         677 AA.
AC   Q5RAW8;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   26-NOV-2014, entry version 70.
DE   RecName: Full=WD repeat-containing protein 48;
DE   AltName: Full=USP1-associated factor 1;
GN   Name=WDR48; Synonyms=UAF1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of deubiquitinating complexes. Acts as a
CC       strong activator of USP1 by enhancing the USP1-mediated
CC       deubiquitination of FANCD2; USP1 being almost inactive by itself.
CC       Also activates deubiquitinating activity of complexes containing
CC       USP12 and USP46, respectively. Activates deubiquitination by
CC       increasing the catalytic turnover without increasing the affinity
CC       of deubiquitinating enzymes for the substrate. May play a role in
CC       vesicular transport or membrane fusion events necessary for
CC       transport to lysosomes (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with USP1, USP12 and USP46. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm
CC       {ECO:0000250}. Lysosome {ECO:0000250}.
CC   -!- DOMAIN: The WD repeats are required for the interaction with
CC       deubiquitinating enzymes USP1, USP12 and USP46. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR48 family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 8 WD repeats. {ECO:0000255|PROSITE-
CC       ProRule:PRU00221}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CR858893; CAH91092.1; -; mRNA.
DR   RefSeq; NP_001125636.1; NM_001132164.2.
DR   ProteinModelPortal; Q5RAW8; -.
DR   Ensembl; ENSPPYT00000016282; ENSPPYP00000015661; ENSPPYG00000014001.
DR   GeneID; 100172554; -.
DR   KEGG; pon:100172554; -.
DR   CTD; 57599; -.
DR   GeneTree; ENSGT00770000120636; -.
DR   HOVERGEN; HBG079413; -.
DR   InParanoid; Q5RAW8; -.
DR   KO; K15361; -.
DR   OMA; ENEINHV; -.
DR   OrthoDB; EOG7JDQX1; -.
DR   TreeFam; TF315205; -.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR   GO; GO:0048568; P:embryonic organ development; IEA:Ensembl.
DR   GO; GO:0048872; P:homeostasis of number of cells; IEA:Ensembl.
DR   GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR   GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
DR   GO; GO:0016579; P:protein deubiquitination; ISS:UniProtKB.
DR   GO; GO:1902525; P:regulation of protein monoubiquitination; IEA:Ensembl.
DR   GO; GO:0072520; P:seminiferous tubule development; IEA:Ensembl.
DR   GO; GO:0007338; P:single fertilization; IEA:Ensembl.
DR   GO; GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
DR   GO; GO:0043588; P:skin development; IEA:Ensembl.
DR   GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR021772; DUF3337.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   Pfam; PF11816; DUF3337; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Complete proteome; Cytoplasm; Lysosome; Nucleus;
KW   Phosphoprotein; Reference proteome; Repeat; Ubl conjugation pathway;
KW   WD repeat.
FT   CHAIN         1    677       WD repeat-containing protein 48.
FT                                /FTId=PRO_0000051402.
FT   REPEAT       28     67       WD 1.
FT   REPEAT       73    112       WD 2.
FT   REPEAT      115    154       WD 3.
FT   REPEAT      166    205       WD 4.
FT   REPEAT      208    247       WD 5.
FT   REPEAT      250    289       WD 6.
FT   REPEAT      292    334       WD 7.
FT   REPEAT      358    452       WD 8.
FT   MOD_RES      28     28       Phosphotyrosine. {ECO:0000250}.
FT   MOD_RES     214    214       N6-acetyllysine. {ECO:0000250}.
FT   MOD_RES     578    578       N6-acetyllysine. {ECO:0000250}.
SQ   SEQUENCE   677 AA;  76223 MW;  3A5E28880EC4883D CRC64;
     MAAHHRQNTA GRRKVQVSYV IRDEVEKYNR NGVNALQLDP ALNRLFTAGR DSIIRIWSVN
     QHKQDPYIAS MEHHTDWVND IVLCCNGKTL ISASSDTTVK VWNAHKGFCM STLRTHKDYV
     KALAYAKDKE LVASAGLDRQ IFLWDVNTLT ALTASNNTVT TSSLSGNKDS IYSLAMNQLG
     TIIVSGSTEK VLRVWDPRTC AKLMKLKGHT DNVKALLLNR DGTQCLSGSS DGTIRLWSLG
     QQRCIATYRV HDEGVWALQV NDAFTHVYSG GRDRKIYCTD LRNPDIRVLI CEEKAPVLKM
     ELDRSADPPP AIWVATTKST VNKWILKGIH NFRASGDYDN DCTNPITPLC TQPDQVIKGG
     ASIIQCHILN DKRHILTKDT NNNVAYWDVL KACKVEDLGK VDFEDEIKKR FKMVYVPNWF
     SVDLKTGMLT ITLDESDCFA AWVSAKDAGF SSPDGSDPKL NLGGLLLQAL LEYWPRTHVN
     PMDEEENEVN HVNGEQENRV QKGNGYFQVP PHTPVIFGEA GGRTLFRLLC RDSGGETESM
     LLNETVPQWV IDITVDKNMP KFNKIPFYLQ PHASSGAKTL KKDRLSASDM LQVRKVMEHV
     YEKIINLDNE SQTTSSSNNE KPGEQEKEED IAVLAEEKIE LLCQDQVLDP NMDLRTVKHF
     IWKSGGDLTL HYRQKST
//
DBGET integrated database retrieval system