ID SC11C_PONAB Reviewed; 192 AA.
AC Q5RC30;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 01-MAY-2013, entry version 65.
DE RecName: Full=Signal peptidase complex catalytic subunit SEC11C;
DE EC=3.4.21.89;
DE AltName: Full=Microsomal signal peptidase 21 kDa subunit;
DE Short=SPase 21 kDa subunit;
DE AltName: Full=SEC11 homolog C;
DE AltName: Full=SEC11-like protein 3;
DE AltName: Full=SPC21;
GN Name=SEC11C; Synonyms=SEC11L3;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the microsomal signal peptidase complex
CC which removes signal peptides from nascent proteins as they are
CC translocated into the lumen of the endoplasmic reticulum (By
CC similarity).
CC -!- CATALYTIC ACTIVITY: Cleavage of hydrophobic, N-terminal signal or
CC leader sequences from secreted and periplasmic proteins.
CC -!- SUBUNIT: Component of the microsomal signal peptidase complex
CC which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and
CC SPCS3 (By similarity).
CC -!- SUBCELLULAR LOCATION: Microsome membrane; Single-pass type II
CC membrane protein (By similarity). Endoplasmic reticulum membrane;
CC Single-pass type II membrane protein (By similarity).
CC -!- SIMILARITY: Belongs to the peptidase S26B family.
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DR EMBL; CR858452; CAH90680.1; -; mRNA.
DR RefSeq; NP_001127320.1; NM_001133848.2.
DR UniGene; Pab.10996; -.
DR ProteinModelPortal; Q5RC30; -.
DR SMR; Q5RC30; 61-158.
DR MEROPS; S26.010; -.
DR PRIDE; Q5RC30; -.
DR Ensembl; ENSPPYT00000010728; ENSPPYP00000010320; ENSPPYG00000009189.
DR GeneID; 100174381; -.
DR KEGG; pon:100174381; -.
DR CTD; 90701; -.
DR GeneTree; ENSGT00390000015600; -.
DR HOVERGEN; HBG057279; -.
DR InParanoid; Q5RC30; -.
DR KO; K13280; -.
DR OMA; NNVDDRG; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR Gene3D; 2.10.109.10; -; 1.
DR InterPro; IPR019758; Pept_S26A_signal_pept_1_CS.
DR InterPro; IPR019756; Pept_S26A_signal_pept_1_Ser-AS.
DR InterPro; IPR019759; Peptidase_S24_S26.
DR InterPro; IPR015927; Peptidase_S24_S26A/B/C.
DR InterPro; IPR011056; Peptidase_S24_S26A/B/C_b-rbn.
DR InterPro; IPR001733; Peptidase_S26B.
DR PANTHER; PTHR10806; PTHR10806; 1.
DR Pfam; PF00717; Peptidase_S24; 1.
DR PRINTS; PR00728; SIGNALPTASE.
DR SUPFAM; SSF51306; Pept_S24_S26_C; 1.
DR TIGRFAMs; TIGR02228; sigpep_I_arch; 1.
DR PROSITE; PS00501; SPASE_I_1; 1.
DR PROSITE; PS00761; SPASE_I_3; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Endoplasmic reticulum; Hydrolase; Membrane;
KW Microsome; Protease; Reference proteome; Signal-anchor; Transmembrane;
KW Transmembrane helix.
FT INIT_MET 1 1 Removed (By similarity).
FT CHAIN 2 192 Signal peptidase complex catalytic
FT subunit SEC11C.
FT /FTId=PRO_0000109550.
FT TOPO_DOM 2 28 Cytoplasmic (Potential).
FT TRANSMEM 29 48 Helical; Signal-anchor for type II
FT membrane protein; (Potential).
FT TOPO_DOM 49 192 Lumenal (Potential).
FT ACT_SITE 68 68 By similarity.
SQ SEQUENCE 192 AA; 21542 MW; 74FBC5F765791D9F CRC64;
MVRAGAVGAH LPASGLDIFG DLKKMNKRQL YYQVLNFAMI VSSALMIWKG LIVLTGSESP
IVVVLSGSME PAFHRGDLLF LTNFREDPIR AGEIVVFKVE GRDIPIVHRV IKVHEKDNGD
IKFLTKGDNN EVDDRGLYKE GQNWLEKKDV VGRARGFLPY VGMVTIIMND YPKFKYALLA
VMGAYVLLKR ES
//
