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Database: UniProt
Entry: Q5RC30
LinkDB: Q5RC30
Original site: Q5RC30 
ID   SC11C_PONAB             Reviewed;         192 AA.
AC   Q5RC30;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   01-OCT-2014, entry version 72.
DE   RecName: Full=Signal peptidase complex catalytic subunit SEC11C;
DE            EC=3.4.21.89;
DE   AltName: Full=Microsomal signal peptidase 21 kDa subunit;
DE            Short=SPase 21 kDa subunit;
DE   AltName: Full=SEC11 homolog C;
DE   AltName: Full=SEC11-like protein 3;
DE   AltName: Full=SPC21;
GN   Name=SEC11C; Synonyms=SEC11L3;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the microsomal signal peptidase complex
CC       which removes signal peptides from nascent proteins as they are
CC       translocated into the lumen of the endoplasmic reticulum.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY: Cleavage of hydrophobic, N-terminal signal or
CC       leader sequences from secreted and periplasmic proteins.
CC   -!- SUBUNIT: Component of the microsomal signal peptidase complex
CC       which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and
CC       SPCS3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250}; Single-
CC       pass type II membrane protein {ECO:0000250}. Endoplasmic reticulum
CC       membrane {ECO:0000250}; Single-pass type II membrane protein
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase S26B family. {ECO:0000305}.
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DR   EMBL; CR858452; CAH90680.1; -; mRNA.
DR   RefSeq; NP_001127320.1; NM_001133848.2.
DR   UniGene; Pab.10996; -.
DR   ProteinModelPortal; Q5RC30; -.
DR   SMR; Q5RC30; 62-113.
DR   MEROPS; S26.010; -.
DR   PRIDE; Q5RC30; -.
DR   Ensembl; ENSPPYT00000010728; ENSPPYP00000010320; ENSPPYG00000009189.
DR   GeneID; 100174381; -.
DR   KEGG; pon:100174381; -.
DR   CTD; 90701; -.
DR   GeneTree; ENSGT00390000015600; -.
DR   HOVERGEN; HBG057279; -.
DR   InParanoid; Q5RC30; -.
DR   KO; K13280; -.
DR   OMA; VYNVKDK; -.
DR   OrthoDB; EOG7V4B0P; -.
DR   TreeFam; TF313648; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR   Gene3D; 2.10.109.10; -; 1.
DR   InterPro; IPR019758; Pept_S26A_signal_pept_1_CS.
DR   InterPro; IPR019756; Pept_S26A_signal_pept_1_Ser-AS.
DR   InterPro; IPR028360; Peptidase_S24/S26_b-rbn.
DR   InterPro; IPR019759; Peptidase_S24_S26.
DR   InterPro; IPR015927; Peptidase_S24_S26A/B/C.
DR   InterPro; IPR001733; Peptidase_S26B.
DR   PANTHER; PTHR10806; PTHR10806; 1.
DR   Pfam; PF00717; Peptidase_S24; 1.
DR   PRINTS; PR00728; SIGNALPTASE.
DR   SUPFAM; SSF51306; SSF51306; 1.
DR   TIGRFAMs; TIGR02228; sigpep_I_arch; 1.
DR   PROSITE; PS00501; SPASE_I_1; 1.
DR   PROSITE; PS00761; SPASE_I_3; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Endoplasmic reticulum; Hydrolase; Membrane;
KW   Microsome; Protease; Reference proteome; Signal-anchor; Transmembrane;
KW   Transmembrane helix.
FT   INIT_MET      1      1       Removed. {ECO:0000250}.
FT   CHAIN         2    192       Signal peptidase complex catalytic
FT                                subunit SEC11C.
FT                                /FTId=PRO_0000109550.
FT   TOPO_DOM      2     28       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     29     48       Helical; Signal-anchor for type II
FT                                membrane protein. {ECO:0000255}.
FT   TOPO_DOM     49    192       Lumenal. {ECO:0000255}.
FT   ACT_SITE     68     68       {ECO:0000250}.
SQ   SEQUENCE   192 AA;  21542 MW;  74FBC5F765791D9F CRC64;
     MVRAGAVGAH LPASGLDIFG DLKKMNKRQL YYQVLNFAMI VSSALMIWKG LIVLTGSESP
     IVVVLSGSME PAFHRGDLLF LTNFREDPIR AGEIVVFKVE GRDIPIVHRV IKVHEKDNGD
     IKFLTKGDNN EVDDRGLYKE GQNWLEKKDV VGRARGFLPY VGMVTIIMND YPKFKYALLA
     VMGAYVLLKR ES
//
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