GenomeNet

Database: UniProt
Entry: Q5RFR6
LinkDB: Q5RFR6
Original site: Q5RFR6 
ID   K319L_PONAB             Reviewed;        1049 AA.
AC   Q5RFR6; Q5R745;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   19-MAR-2014, entry version 49.
DE   RecName: Full=Dyslexia-associated protein KIAA0319-like protein;
GN   Name=KIAA0319L;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain cortex, and Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possible role in axon guidance through interaction with
CC       RTN4R (By similarity).
CC   -!- SUBUNIT: Interacts with RTN4R (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic granule membrane; Multi-pass
CC       membrane protein (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5RFR6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5RFR6-2; Sequence=VSP_032957;
CC         Note=No experimental confirmation available;
CC   -!- PTM: N-glycosylated (By similarity).
CC   -!- SIMILARITY: Contains 1 MANSC domain.
CC   -!- SIMILARITY: Contains 5 PKD domains.
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DR   EMBL; CR857086; CAH89391.1; -; mRNA.
DR   EMBL; CR860273; CAH92415.1; -; mRNA.
DR   RefSeq; NP_001124549.1; NM_001131077.1.
DR   ProteinModelPortal; Q5RFR6; -.
DR   SMR; Q5RFR6; 307-402, 600-688.
DR   Ensembl; ENSPPYT00000001854; ENSPPYP00000001797; ENSPPYG00000001558. [Q5RFR6-1]
DR   GeneID; 100127092; -.
DR   KEGG; pon:100127092; -.
DR   CTD; 79932; -.
DR   GeneTree; ENSGT00740000115558; -.
DR   HOGENOM; HOG000043880; -.
DR   HOVERGEN; HBG057130; -.
DR   InParanoid; Q5R745; -.
DR   OrthoDB; EOG79PJNJ; -.
DR   TreeFam; TF323356; -.
DR   GO; GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.670; -; 2.
DR   InterPro; IPR003961; Fibronectin_type3.
DR   InterPro; IPR013980; MANSC.
DR   InterPro; IPR022409; PKD/Chitinase_dom.
DR   InterPro; IPR002859; PKD/REJ-like.
DR   InterPro; IPR000601; PKD_dom.
DR   Pfam; PF02010; REJ; 2.
DR   SMART; SM00060; FN3; 4.
DR   SMART; SM00089; PKD; 5.
DR   SUPFAM; SSF49299; SSF49299; 4.
DR   PROSITE; PS50986; MANSC; 1.
DR   PROSITE; PS50093; PKD; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Glycoprotein; Membrane;
KW   Phosphoprotein; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN         1   1049       Dyslexia-associated protein KIAA0319-like
FT                                protein.
FT                                /FTId=PRO_0000329066.
FT   TOPO_DOM      1     29       Cytoplasmic (Potential).
FT   TRANSMEM     30     50       Helical; (Potential).
FT   TOPO_DOM     51    932       Extracellular (Potential).
FT   TRANSMEM    933    953       Helical; (Potential).
FT   TOPO_DOM    954   1049       Cytoplasmic (Potential).
FT   DOMAIN       49    127       MANSC.
FT   DOMAIN      310    401       PKD 1.
FT   DOMAIN      409    498       PKD 2.
FT   DOMAIN      504    594       PKD 3.
FT   DOMAIN      600    688       PKD 4.
FT   DOMAIN      694    785       PKD 5.
FT   MOD_RES    1037   1037       Phosphothreonine (By similarity).
FT   CARBOHYD    247    247       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    395    395       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    487    487       N-linked (GlcNAc...) (Potential).
FT   VAR_SEQ       1    358       Missing (in isoform 2).
FT                                /FTId=VSP_032957.
FT   CONFLICT    397    397       T -> A (in Ref. 1; CAH92415).
FT   CONFLICT    995    995       V -> A (in Ref. 1; CAH92415).
SQ   SEQUENCE   1049 AA;  115740 MW;  32F20C9AFF4D8A49 CRC64;
     MEKRLGVKPN PASWILSGYY WQTSAKWLRT LYLFYTCFCF SVLWLSTDAS ESRCQQGKTQ
     FGVGLRSGGE NHLWLLEGTP SLQSCWAACC QDSACHVFWW LEGMCIQADC SRPQSCRAFR
     THSSNSMLMF LKKFQTADDL GFLPEDDVPH LLGLGWNWAS WRQSPPRAAL RPAVSSSDQQ
     SLIRKLQKRG SPSEVVTPIV TQHSKVNDSN ELGGLTTSGS AEVHKAITIS SPLTTDLTAE
     LPGGPKNVSA QPEIPEGLAT TPSTQQVKSS EKTQIAVPQP VAPSYSYGTP TPQASFQSTS
     APYPVIKELV VSAGDSVQIT LPKNEVQLNA YVLQEPPKGE TYTYDWQLIT HPRDYSGEME
     GKHSQILKLS KLTPGLYEFK VIVEGQNAHG EGYVNVTVKP EPRKNRPPIA IVSPQFQEIS
     LPTTSTVIDG SQSTDDDKIV QYHWEELKGP LREEKISEDT AILKLSKLVP GNYTFSLTVV
     DSDGATNSTT ANLTVNKAVD YPPVANAGPN QVITLPQNSI TLFGNQSTDD HGITSYEWSL
     SPSSKGKVVE MQGVRTPTLQ LSAMQEGDYT YQLTVTDTIG QQATAQVTVI VQPENNKPPQ
     ADAGPDKELT LPVDSTTLDG SKSSDDQKII SYLWEKTQGP DGVQLENANS SIATVTGLQV
     GTYVFTLTVK DERNLQSQSS VNVIVKEEIN KPPIAKITGN VVITLPTSTA ELDGSKSSDD
     KGIVSYLWTR DEGSPAAGEV LNHSDHHPIL FLSNLVEGTY TFHLKVTDAK GESDTDRTTV
     EVKPDPRKNN LVEIILDINV SQLTERLKGM FIRQIGVLLG VLDSDIIVQK IQPYTEQSTK
     MVFFVQNEPP HQIFKGHEVA AMLKSELRKQ KADFLIFRAL EINTVTCQLN CSDHGHCDSF
     TKRCICDPFW MENFIKVQLR DGESNCEWSV LYVIIATFVI VVALGILSWT VICCCKRQKG
     KPKRKSKYKI LDATDQESLE LKPTSRTGIK QKGLVLSSSL MHSESELDSD DAIFTWPDRE
     KGKLLHGQNG SVPNGQTPLK ARSPREEIL
//
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