ID   Q5RZ99_HUMAN            Unreviewed;       225 AA.
AC   Q5RZ99;
DT   21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT   21-DEC-2004, sequence version 1.
DT   27-MAR-2024, entry version 74.
DE   SubName: Full=Apoptosis-inducing factor {ECO:0000313|EMBL:AAV54054.1};
DE   Flags: Fragment;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAV54054.1};
RN   [1] {ECO:0000313|EMBL:AAV54054.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Skoblenick K.J., Rogoza R.M., Castellano J.M., Dyck B.A., Thomas N.,
RA   Marriott J., Gabriele J., Chong V.Z., Mishra R.K.;
RT   "Translocation of apoptosis-inducing factor in human neuroblastoma SH-SY5Y
RT   cells following antipsychotic drug treatment.";
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AY795557; AAV54054.1; -; mRNA.
DR   AlphaFoldDB; Q5RZ99; -.
DR   SMR; Q5RZ99; -.
DR   IntAct; Q5RZ99; 7.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   PANTHER; PTHR43557; APOPTOSIS-INDUCING FACTOR 1; 1.
DR   PANTHER; PTHR43557:SF4; APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL; 1.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   PRINTS; PR00368; FADPNR.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   2: Evidence at transcript level;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT   DOMAIN          25..219
FT                   /note="FAD/NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF07992"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAV54054.1"
FT   NON_TER         225
FT                   /evidence="ECO:0000313|EMBL:AAV54054.1"
SQ   SEQUENCE   225 AA;  24425 MW;  F9978F318356CFE7 CRC64;
     KAALSASEGE EVPQDIVPSH VPFLLIGGGT AAFAAARSIR ARDPGARVLI VSEDPELPYM
     RPPLSKELWF SDDPNVTKTL RFKQWNGKER SIYFQPPSFY VSAQDLPHIE NGGVAVLTGK
     KVVQLDVRGN MVKLNDGSQI TYEKCLIATG GTPRSLSAID RAGAEVKSRT TLFRKIGDFR
     SLEKISREVK SITIIGGGFL GSELACALGR KARALGTEVI QLFPE
//