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Database: UniProt
Entry: Q5SUG1_MOUSE
LinkDB: Q5SUG1_MOUSE
Original site: Q5SUG1_MOUSE 
ID   Q5SUG1_MOUSE            Unreviewed;      2248 AA.
AC   Q5SUG1;
DT   21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT   21-DEC-2004, sequence version 1.
DT   25-OCT-2017, entry version 102.
DE   SubName: Full=Calcium channel, voltage-dependent, T type, alpha 1G subunit {ECO:0000313|Ensembl:ENSMUSP00000103415};
GN   Name=Cacna1g {ECO:0000313|Ensembl:ENSMUSP00000103415,
GN   ECO:0000313|MGI:MGI:1201678};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000103415, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000213|PubMed:16452087}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=16452087; DOI=10.1074/mcp.T500041-MCP200;
RA   Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,
RA   Burlingame A.L.;
RT   "Comprehensive identification of phosphorylation sites in postsynaptic
RT   density preparations.";
RL   Mol. Cell. Proteomics 5:914-922(2006).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000103415, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000103415,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0000213|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000103415}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000103415};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000103415}.
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DR   EMBL; AL645965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001171361.1; NM_001177890.1.
DR   UniGene; Mm.29585; -.
DR   ProteinModelPortal; Q5SUG1; -.
DR   PaxDb; Q5SUG1; -.
DR   Ensembl; ENSMUST00000107786; ENSMUSP00000103415; ENSMUSG00000020866.
DR   GeneID; 12291; -.
DR   UCSC; uc011ycw.1; mouse.
DR   CTD; 8913; -.
DR   MGI; MGI:1201678; Cacna1g.
DR   eggNOG; KOG2302; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   HOGENOM; HOG000007742; -.
DR   HOVERGEN; HBG050764; -.
DR   ChiTaRS; Cacna1g; mouse.
DR   Proteomes; UP000000589; Chromosome 11.
DR   Bgee; ENSMUSG00000020866; -.
DR   ExpressionAtlas; Q5SUG1; baseline and differential.
DR   Genevisible; Q5SUG1; MM.
DR   GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR   GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IDA:MGI.
DR   GO; GO:0097110; F:scaffold protein binding; ISO:MGI.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IDA:MGI.
DR   GO; GO:0086056; F:voltage-gated calcium channel activity involved in AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0086059; F:voltage-gated calcium channel activity involved SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0001508; P:action potential; IMP:MGI.
DR   GO; GO:0070509; P:calcium ion import; ISO:MGI.
DR   GO; GO:0070588; P:calcium ion transmembrane transport; ISO:MGI.
DR   GO; GO:0086002; P:cardiac muscle cell action potential involved in contraction; IEA:Ensembl.
DR   GO; GO:0007268; P:chemical synaptic transmission; IGI:MGI.
DR   GO; GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IMP:MGI.
DR   GO; GO:0002027; P:regulation of heart rate; IMP:MGI.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR   GO; GO:0042391; P:regulation of membrane potential; ISO:MGI.
DR   GO; GO:0010045; P:response to nickel cation; IMP:MGI.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR030154; VDCC_T_a1G.
DR   PANTHER; PTHR10037:SF137; PTHR10037:SF137; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:Q5SUG1,
KW   ECO:0000213|PeptideAtlas:Q5SUG1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    123    142       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    214    237       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    342    362       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    368    384       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    727    745       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    757    778       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    848    867       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    924    947       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1238   1256       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1276   1297       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1309   1328       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1373   1395       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1475   1498       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1573   1594       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1606   1629       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1707   1726       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1790   1812       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       80    382       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      726    953       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1236   1508       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1572   1822       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1507   1534       {ECO:0000256|SAM:Coils}.
FT   COILED     1811   1835       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2248 AA;  248863 MW;  47EFAFACBA237E82 CRC64;
     MDEEEDGAGA EESGQPRSFT QLNDLSGAGG RQGPGSTEKD PGSADSEAEG LPYPALAPVV
     FFYLSQDSRP RSWCLRTVCN PWFERVSMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF
     DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR
     TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR
     CFLPENFSLP LSVDLEPYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG EGGGGPPCGL
     DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM
     YFVMDAHSFY NFIYFILLII FSETKQRESQ LMREQRVRFL SNASTLASFS EPGSCYEELL
     KYLVYILRKA ARRLAQVSRA VGVRAGLLSS PVARGGQEPQ PSGSCSRSHR RLSVHHLVHH
     HHHHHHHYHL GNGTLRVPRA SPEIQDRDAN GSRWLMLPPP STPTPSGGPP RGAESVHSFY
     HADCHLEPVR CQAPPPRSPS EASGRTVGSG KVYPTVHTSP PPEMLKDKAL VEVAPSPGPP
     TLTSFNIPPG PFSSMHKLLE TQSTGACHSS CKISSPCSKA DSGACGPDSC PYCARTGAGE
     PESADHEMPD SDSEAVYEFT QDAQHSDLRD PHRRRRPSLG PDAEPSSVLA FWRLICDTFR
     KIVDSKYFGR GIMIAILVNT LSMGIEYHEQ PEELTNALEI SNIVFTSLFA LEMLLKLLVY
     GPFGYIKNPY NIFDGVIVVI SVWEIVGQQG GGLSVLRTFR LMRVLKLVRF LPALQRQLVV
     LMKTMDNVAT FCMLLMLFIF IFSILGMHLF GCKFASERDG DTLPDRKNFD SLLWAIVTVF
     QILTQEDWNK VLYNGMASTS SWAALYFIAL MTFGNYVLFN LLVAILVEGF QAEGDATKSE
     SEPDFFSPSV DGDGDRKKRL ALVALGEHSE LRKSLLPPLI IHTAATPMSL PKSSSTGVGE
     ALGSGSRRTS SSGSAEPGTA HHEMKSPPSA RSSPHSPWSA ASSWTSRRSS RNSLGRAPSL
     KRRSPSGERR SLLSGEGQES QDEEESSEED RASPAGSDHR HRGSLEREAK SSFDLPDTLQ
     VPGLHRTASG RSSASEHQDC NGKSASGRLA RTLRADDPPL DGDDGDDEGN LSKGERLRAW
     VRARLPACCR ERDSWSAYIF PPQSRFRLLC HRIITHKMFD HVVLVIIFLN CITIAMERPK
     IDPHSAERIF LTLSNYIFTA VFLAEMTVKV VALGWCFGEQ AYLRSSWNVL DGLLVLISVI
     DILVSMVSDS GTKILGMLRV LRLLRTLRPL RVISRAQGLK LVVETLMSSL KPIGNIVVIC
     CAFFIIFGIL GVQLFKGKFF VCQGEDTRNI TNKSDCAEAS YRWVRHKYNF DNLGQALMSL
     FVLASKDGWV DIMYDGLDAV GVDQQPIMNH NPWMLLYFIS FLLIVAFFVL NMFVGVVVEN
     FHKCRQHQEE EEARRREEKR LKRLEKKRRN LMLDDVIASG SSASAASEAQ CKPYYSDYSR
     FRLLVHHLCT SHYLDLFITG VIGLNVVTMA MEHYQQPQIL DEALKICNYI FTVIFVLESV
     FKLVAFGFRR FFQDRWNQLD LAIVLLSIMG ITLEEIEVNA SLPINPTIIR IMRVLRIARV
     LKLLKMAVGM RALLDTVMQA LPQVGNLGLL FMLLFFIFAA LGVELFGDLE CDETHPCEGL
     GRHATFRNFG MAFLTLFRVS TGDNWNGIMK DTLRDCDQES TCYNTVISPI YFVSFVLTAQ
     FVLVNVVIAV LMKHLEESNK EAKEEAELEA ELELEMKTLS PQPHSPLGSP FLWPGVEGVN
     SPDSPKPGAP HTTAHIGAAS SGFSLEHPTM VPHTEEGPVP LGPDLLTVRK SGVSRTHSLP
     NDSYMCRNGS TAERSLGHRG WGLPKAQSGS ILSVHSQPAD TSCILQLPKD AHYLLQPHGA
     PTWGAIPKLP PPGRSPLAQR PLRRQAAIRT DSLDVQGLGS REDLLSEVSG PSCPLTRSSS
     FWGGSSIQVQ QRSGSQSKVS KHIRLPAPCP GLEPSWAKDP QETRSSLELD TELSWISGDL
     LPSSQEEPLS PRDLKKCYSV EAQSCRRRPG SWLDEQRRHS IAVSCLDSGS QPRLCPSPSS
     LGGQPLGGPG SRPKKKLSPP SISIDPPESQ GPRPPCSPGV CLRRRAPASD SKDPSASSPL
     DSTAASPSPK KDALSLSGLS SDPTDLDP
//
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