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Database: UniProt
Entry: Q5TPQ2_ANOGA
LinkDB: Q5TPQ2_ANOGA
Original site: Q5TPQ2_ANOGA 
ID   Q5TPQ2_ANOGA            Unreviewed;      2092 AA.
AC   Q5TPQ2;
DT   07-DEC-2004, integrated into UniProtKB/TrEMBL.
DT   23-OCT-2007, sequence version 3.
DT   25-OCT-2017, entry version 101.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=1278521 {ECO:0000313|VectorBase:AGAP004707-PM};
GN   ORFNames=AgaP_AGAP004707 {ECO:0000313|EMBL:EAL39442.3};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=7165 {ECO:0000313|EMBL:EAL39442.3, ECO:0000313|Proteomes:UP000007062};
RN   [1] {ECO:0000313|VectorBase:AGAP004707-PM}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|VectorBase:AGAP004707-PM};
RX   PubMed=9087549; DOI=10.1111/j.1365-2583.1993.tb00131.x;
RA   Beard C.B., Hamm D.M., Collins F.H.;
RT   "The mitochondrial genome of the mosquito Anopheles gambiae: DNA
RT   sequence, genome organization, and comparisons with mitochondrial
RT   sequences of other insects.";
RL   Insect Mol. Biol. 2:103-124(1993).
RN   [2] {ECO:0000313|EMBL:EAL39442.3, ECO:0000313|Proteomes:UP000007062}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|EMBL:EAL39442.3,
RC   ECO:0000313|Proteomes:UP000007062};
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M., Wides R.,
RA   Salzberg S.L., Loftus B., Yandell M., Majoros W.H., Rusch D.B.,
RA   Lai Z., Kraft C.L., Abril J.F., Anthouard V., Arensburger P.,
RA   Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V.,
RA   Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S.,
RA   Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.,
RA   Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I.,
RA   Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z.,
RA   Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R.,
RA   Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C., Kokoza E.,
RA   Koutsos A., Letunic I., Levitsky A., Liang Y., Lin J.J., Lobo N.F.,
RA   Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.,
RA   Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C.,
RA   Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V.,
RA   Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D.,
RA   Ton L.Q., Topalis P., Tu Z., Unger M.F., Walenz B., Wang A., Wang J.,
RA   Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A.,
RA   Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F.,
RA   Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S.,
RA   Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C.,
RA   Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
RN   [3] {ECO:0000313|EMBL:EAL39442.3}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAL39442.3};
RG   The Anopheles Genome Sequencing Consortium;
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:EAL39442.3}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAL39442.3};
RX   PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA   Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT   "The Anopheles gambiae genome: an update.";
RL   Trends Parasitol. 20:49-52(2004).
RN   [5] {ECO:0000313|EMBL:EAL39442.3}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAL39442.3};
RX   PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA   Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA   Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT   "Update of the Anopheles gambiae PEST genome assembly.";
RL   Genome Biol. 8:R5-R5(2007).
RN   [6] {ECO:0000313|EMBL:EAL39442.3}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAL39442.3};
RG   VectorBase;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|VectorBase:AGAP004707-PM}
RP   IDENTIFICATION.
RC   STRAIN=PEST {ECO:0000313|VectorBase:AGAP004707-PM};
RG   VectorBase;
RL   Submitted (JUN-2017) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AAAB01008968; EAL39442.3; -; Genomic_DNA.
DR   RefSeq; XP_554647.3; XM_554647.3.
DR   ProteinModelPortal; Q5TPQ2; -.
DR   PaxDb; Q5TPQ2; -.
DR   EnsemblMetazoa; AGAP004707-RC; AGAP004707-PC; AGAP004707.
DR   GeneID; 1278521; -.
DR   VectorBase; AGAP004707-RM; AGAP004707-PM; AGAP004707.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   HOGENOM; HOG000231755; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000007062; Chromosome 2L.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007062};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    127    154       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    198    220       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    232    250       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    256    278       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    387    409       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    777    800       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    821    838       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    850    874       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    905    927       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    985   1006       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1295   1317       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1323   1349       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1370   1401       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1491   1517       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1580   1598       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1610   1629       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1641   1660       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1704   1727       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1797   1817       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1834   1869       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED       24     51       {ECO:0000256|SAM:Coils}.
FT   COILED      413    451       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2092 AA;  234659 MW;  E6B8BCFF4EBB05DA CRC64;
     MTEDSDSISE EERSLFRPFT RESLQAIEAR IADEEAKQRE LERKRAEGED EDEGPQPDPT
     LEQGVPVPVR MQGSFPPELA STPLEDIDSF YSNQRTFVVI SKGKDIFRFS ATNALYVLDP
     FNPIRRVAIY ILVHPLFSLF IITTILVNCI LMIMPTTPTV ESTEVIFTGI YTFESAVKVM
     ARGFILQPFT YLRDAWNWLD FVVIALAYVT MGIDLGNLAA LRTFRVLRAL KTVAIVPGLK
     TIVGAVIESV KNLRDVIILT MFSLSVFALM GLQIYMGVLT QKCIKEFPLD GSWGNLTDES
     WELFNSNDTN WFYSESGDIP LCGNSSGAGQ CDEGYICLQG YGKNPNYGYT SFDTFGWAFL
     SAFRLMTQDY WENLYQLVLR SAGPWHMLFF IVIIFLGSFY LVNLILAIVA MSYDELQKKA
     EEEEAAEEEA LREAEEAAAA KAAKLEAQQA AAAAAANPEI AKSPSDFSCH SYELFVGQEK
     GNDDNNKEKM SIRSEGLESV SEITRTTAPT ATAAGTAKAR KVSAASLSLP GSPFNLRRGS
     RGSHQFTIRN GRGRFVGVPG SDRKPLVLST YLDAQEHLPY ADDSNAVTPM SEENGAIIVP
     VYYANLGSRH SSYTSHQSRI SYTSHGDLLG GMTKESRLRN RSARNTNHSI VPPPNANNLS
     YAETNHKGQR DFDLTQDCTD DAGKIKHNDN PFIEPAQTQT VVDMKDVMVL NDIIEQAAGR
     HSRASDHGVS VYYFPTEDDD EDGPTFKDKA LEFLMKMIDI FCVWDCCWVW LKFQEWVAFI
     VFDPFVELFI TLCIVVNTLF MALDHHDMDP DMEKALKSGN YFFTATFAIE ATMKLIAMSP
     KYYFQEGWNI FDFIIVALSL LELGLEGVQG LSVLRSFRLL RVFKLAKSWP TLNLLISIMG
     RTVGALGNLT FVLCIIIFIF AVMGMQLFGK NYTDNVDRFP DHDLPRWNFT DFMHSFMIVF
     RVLCGEWIES MWDCMLVGDV SCIPFFLATV VIGNLVVLNL FLALLLSNFG SSSLSAPTAD
     NETNKIAEAF NRISRFSNWI KMNLANALKF VKNKLTSQIA SVQPTGKGVC PCISSEHGEN
     ELELTPDDIL ADGLLKKGIK EHNQLEVAIG DGMEFTIHGD LKNKAKKNKQ IMNNSKDDDT
     ASIKSYGSHK NRPFKDESHK GSAETMEGEE KRDASKEDLG IDEELDDEGE GDEGPLDGEL
     IIHAEEDEVI EDSPADCCPD NCYKKFPVLA GDDDAPFWQG WGNLRLKTFQ LIENKYFETA
     VITMILLSSL ALALEDVHLP QRPILQDILY YMDRIFTVIF FLEMLIKWLA LGFKVYFTNA
     WCWLDFIIVM VSLINFVASL CGAGGIQAFK TMRTLRALRP LRAMSRMQGM RVVVNALVQA
     IPSIFNVLLV CLIFWLIFAI MGVQLFAGKY FKCVDKNKTT LPHEIIPDVN ACKAENYSWE
     NSPMNFDHVG KAYLCLFQVA TFKGWIQIMN DAIDSRDVSF VGKQPIRETN IYMYLYFVFF
     IIFGSFFTLN LFIGVIIDNF NEQKKKAGGS LEMFMTEDQK KYYNAMKKMG SKKPLKAIPR
     PRWRPQAIVF EIVTNKKFDM IIMLFIGFNM LTMTLDHYKQ SETFSAVLDY LNMIFICIFS
     SECLMKIFAL RYHYFIEPWN LFDFVVVILS ILGLVLSDII EKYFVSPTLL RVVRVAKVGR
     VLRLVKGAKG IRTLLFALAM SLPALFNICL LLFLVMFIFA IFGMSFFMHV KDKSGLDDVY
     NFKTFGQSMI LLFQMSTSAG WDGVLDGIIN EEDCLPPDND KGYPGNCGSS TIGITYLLAY
     LVISFLIVIN MYIAVILENY SQATEDVQEG LTDDDYDMYY EIWQQFDPDG TQYVRYDQLS
     DFLDVLEPPL QIHKPNRYKI ISMDIPICRG DMMFCVDILD ALTKDFFARK GNPIEETAEL
     GEVQQRPDEV GYEPVSSTLW RQREEYCARL IQHAWKRYKQ RHGGGTDASG DDLEIDACDN
     GCGGGNGNEN DDSGDGATGS GDNGSQHGGG SISGGGGTPG GGKSKGIIGS TQANIGIVDS
     NISPKESPDS IGDPQGRQTA VLVESDGFVT KNGHRVVIHS RSPSITSRTA DV
//
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