ID Q5U3W7_DANRE Unreviewed; 352 AA.
AC Q5U3W7;
DT 07-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 07-DEC-2004, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=Zgc:101549 {ECO:0000313|EMBL:AAH85365.1};
GN Name=nansb {ECO:0000313|ZFIN:ZDB-GENE-041114-125};
GN ORFNames=zgc:101549 {ECO:0000313|EMBL:AAH85365.1,
GN ECO:0000313|RefSeq:NP_001007421.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH85365.1};
RN [1] {ECO:0000313|EMBL:AAH85365.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gut {ECO:0000313|EMBL:AAH85365.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:NP_001007421.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [4] {ECO:0000313|RefSeq:NP_001007421.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27213289; DOI=10.1038/ng.3578;
RA van Karnebeek C.D., Bonafe L., Wen X.Y., Tarailo-Graovac M., Balzano S.,
RA Royer-Bertrand B., Ashikov A., Garavelli L., Mammi I., Turolla L.,
RA Breen C., Donnai D., Cormier-Daire V., Heron D., Nishimura G., Uchikawa S.,
RA Campos-Xavier B., Rossi A., Hennet T., Brand-Arzamendi K., Rozmus J.,
RA Harshman K., Stevenson B.J., Girardi E., Superti-Furga G., Dewan T.,
RA Collingridge A., Halparin J., Ross C.J., Van Allen M.I., Rossi A.,
RA Engelke U.F., Kluijtmans L.A., van der Heeft E., Renkema H., de Brouwer A.,
RA Huijben K., Zijlstra F., Heise T., Boltje T., Wasserman W.W., Rivolta C.,
RA Unger S., Lefeber D.J., Wevers R.A., Superti-Furga A.;
RT "NANS-mediated synthesis of sialic acid is required for brain and skeletal
RT development.";
RL Nat. Genet. 48:777-784(2016).
RN [5] {ECO:0000313|RefSeq:NP_001007421.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28132765;
RA Zhang D., Wang J., Zhou C., Xiao W.;
RT "Zebrafish akt2 is essential for survival, growth, bone development, and
RT glucose homeostasis.";
RL Mech. Dev. 143:42-52(2017).
RN [6] {ECO:0000313|RefSeq:NP_001007421.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; BC085365; AAH85365.1; -; mRNA.
DR RefSeq; NP_001007421.1; NM_001007420.1.
DR GeneID; 492779; -.
DR KEGG; dre:492779; -.
DR AGR; ZFIN:ZDB-GENE-041114-125; -.
DR CTD; 492779; -.
DR ZFIN; ZDB-GENE-041114-125; nansb.
DR OrthoDB; 3716025at2759; -.
DR PhylomeDB; Q5U3W7; -.
DR TreeFam; TF324826; -.
DR Proteomes; UP000000437; Chromosome 25.
DR GO; GO:0016051; P:carbohydrate biosynthetic process; IEA:InterPro.
DR CDD; cd11615; SAF_NeuB_like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.90.1210.10; Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain; 1.
DR InterPro; IPR006190; AFP_Neu5c_C.
DR InterPro; IPR036732; AFP_Neu5c_C_sf.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR013132; Neu5Ac_N.
DR InterPro; IPR013974; SAF.
DR PANTHER; PTHR42966; N-ACETYLNEURAMINATE SYNTHASE; 1.
DR PANTHER; PTHR42966:SF1; SIALIC ACID SYNTHASE; 1.
DR Pfam; PF03102; NeuB; 1.
DR Pfam; PF08666; SAF; 1.
DR SMART; SM00858; SAF; 1.
DR SUPFAM; SSF51269; AFP III-like domain; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS50844; AFP_LIKE; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 294..352
FT /note="AFP-like"
FT /evidence="ECO:0000259|PROSITE:PS50844"
SQ SEQUENCE 352 AA; 39075 MW; 453CFA4D4BF4EBF6 CRC64;
MPVEFELCPG RKIGGSNPCF IIAEIGQNHQ GDVEIAKKMI RMAKDCGADC AKFQKSEIEH
RFTRNALDRL YTSPHAWGPT YGAHKHHLEF SHEQYRELQQ YATDIGIFFT ASGMDEMAVE
FLHEINVPFF KVASADTNNI PYLEKTAKKG RPMVISSGMQ SMETMRCVYQ TVKKHNANFT
FLQCTSAYPL PLEHVNLSLI TEFQKEFPDI PIGYSGHETG IHVSVAAVAL GAKVLERHVT
LDKSWKGSDH AASLEPDELA ELVKAIRAVE MAMGSPVKQM LPCEASCHSK LGKSVVARKP
LKMGETLTLD MLTVKVAEPQ GVRPENIFKL VGKKISVNLE KDATITDAMI KG
//
