ID Q5U8N1_ENTHI Unreviewed; 414 AA.
AC Q5U8N1; A0A175JHH4; C4LW45;
DT 07-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 07-DEC-2004, sequence version 1.
DT 27-MAR-2024, entry version 116.
DE RecName: Full=Histone acetyltransferase {ECO:0000256|ARBA:ARBA00013184, ECO:0000256|RuleBase:RU361211};
DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184, ECO:0000256|RuleBase:RU361211};
OS Entamoeba histolytica.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=5759 {ECO:0000313|EMBL:AAV33346.1};
RN [1] {ECO:0000313|EMBL:AAV33346.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HM1-IMSS {ECO:0000313|EMBL:AAV33346.1};
RA Ramakrishnan G., Gilchrist C.A., Musa H., Torok M.S., Grant P.A.,
RA Mann B.J., Petri W.A. Jr.;
RT "Histone acetyltransferases and deacetylase in Entamoeba histolytica.";
RL Mol. Biochem. Parasitol. 0:0-0(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-
CC lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752,
CC Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48;
CC Evidence={ECO:0000256|RuleBase:RU361211};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU361211}.
CC -!- SIMILARITY: Belongs to the MYST (SAS/MOZ) family.
CC {ECO:0000256|ARBA:ARBA00010107, ECO:0000256|RuleBase:RU361211}.
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DR EMBL; AY779020; AAV33346.1; -; Genomic_DNA.
DR AlphaFoldDB; Q5U8N1; -.
DR STRING; 5759.Q5U8N1; -.
DR EnsemblProtists; GAT92918; GAT92918; CL6EHI_142000.
DR EnsemblProtists; rna_EHI_142000-1; rna_EHI_142000-1; EHI_142000.
DR VEuPathDB; AmoebaDB:EHI5A_046910; -.
DR VEuPathDB; AmoebaDB:EHI7A_036760; -.
DR VEuPathDB; AmoebaDB:EHI8A_036080; -.
DR VEuPathDB; AmoebaDB:EHI_142000; -.
DR VEuPathDB; AmoebaDB:KM1_058450; -.
DR HOGENOM; CLU_011815_2_1_1; -.
DR InParanoid; Q5U8N1; -.
DR OMA; ILCEVDK; -.
DR OrthoDB; 118560at2759; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004402; F:histone acetyltransferase activity; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd04301; NAT_SF; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 3.40.630.30; -; 1.
DR Gene3D; 3.30.60.60; N-acetyl transferase-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR002717; HAT_MYST-type.
DR InterPro; IPR025995; Tudor-knot.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR040706; Zf-MYST.
DR PANTHER; PTHR10615; HISTONE ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR10615:SF161; HISTONE ACETYLTRANSFERASE KAT5; 1.
DR Pfam; PF01853; MOZ_SAS; 1.
DR Pfam; PF11717; Tudor-knot; 1.
DR Pfam; PF17772; zf-MYST; 1.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR PROSITE; PS51726; MYST_HAT; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|RuleBase:RU361211};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT ACT_SITE 301
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
SQ SEQUENCE 414 AA; 48490 MW; 2EF5D4219343944F CRC64;
MSNILRFKIN EKVLCHKHED PEGSYREARI LETREHNGNT EYYVRYTEYN KRLDEWTAAN
NIIRYSSKEN IIRPTTKEDG VSQRKMTRAL RQSNVSMLEK DSEVIDKTTP QENEIFQRTK
NIQHVTIGDY DLNVWYFSPY PGEYGHAERL YICEHCLKYM SKANTYIKHR EHCPYHFPPG
LLIYKDDERH LAFFEVDGAE AKMFCQSLCL LSKMFLDHKT LYYDVEPFYF YVLCEFNYNE
QWKSDDYHIV GYFSKEKASP DGYNLSCLMV LPHHQRKGYG KMLISMSYEL SKIEGIPGSP
EKPLSDLGLV SFKSYWSGVI AEELLNSTEI PSIEDLTLKT GITKEDCVSA LDTLNCISPY
RGSQIISINH IKMEALREKC SKKVVLVKKE LLHWKPHSVV VKYPNVMQTL KTYC
//