ID Q5UHD1_CITFR Unreviewed; 482 AA.
AC Q5UHD1;
DT 07-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 07-DEC-2004, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=mannose-1-phosphate guanylyltransferase {ECO:0000256|ARBA:ARBA00012387};
DE EC=2.7.7.13 {ECO:0000256|ARBA:ARBA00012387};
GN Name=manC {ECO:0000313|EMBL:AAV34502.1};
OS Citrobacter freundii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Citrobacter; Citrobacter freundii complex.
OX NCBI_TaxID=546 {ECO:0000313|EMBL:AAV34502.1};
RN [1] {ECO:0000313|EMBL:AAV34502.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=M1972 {ECO:0000313|EMBL:AAV34502.1};
RX PubMed=15375135; DOI=10.1128/JB.186.19.6536-6543.2004;
RA Samuel G., Hogbin J.P., Wang L., Reeves P.R.;
RT "Relationships of the Escherichia coli O157, O111, and O55 O-antigen gene
RT clusters with those of Salmonella enterica and Citrobacter freundii, which
RT express identical O antigens.";
RL J. Bacteriol. 186:6536-6543(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC ChEBI:CHEBI:58409; EC=2.7.7.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001083};
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC route): step 1/1. {ECO:0000256|ARBA:ARBA00004823}.
CC -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 2 family.
CC {ECO:0000256|ARBA:ARBA00006115, ECO:0000256|RuleBase:RU004190}.
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DR EMBL; AY730592; AAV34502.1; -; Genomic_DNA.
DR AlphaFoldDB; Q5UHD1; -.
DR UniPathway; UPA00126; UER00930.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:UniProtKB-EC.
DR GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR CDD; cd02213; cupin_PMI_typeII_C; 1.
DR CDD; cd02509; GDP-M1P_Guanylyltransferase; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR006375; Man1P_GuaTrfase/Man6P_Isoase.
DR InterPro; IPR001538; Man6P_isomerase-2_C.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR NCBIfam; TIGR01479; GMP_PMI; 1.
DR PANTHER; PTHR46390; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR PANTHER; PTHR46390:SF1; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR Pfam; PF01050; MannoseP_isomer; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000313|EMBL:AAV34502.1}.
FT DOMAIN 8..297
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
FT DOMAIN 326..474
FT /note="Mannose-6-phosphate isomerase type II C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01050"
SQ SEQUENCE 482 AA; 54362 MW; 44E13078BE5DD3FC CRC64;
MSDAPLIPVI MAGGTGSRLW PLSRELYPKQ FLHLTEDNSL LQTTLLRLSS LSCKTPLVIS
NEQHRFIVAE QLRQINQLHD NIILEPCGRN TAPAIALAAF SALKRNEKKE PLLLVLAADH
VINESSAFCE AVKNSIPLAE DGHVVTFGII PEYAETGYGY IERGLPLEKN KSSGDSLFYH
VNKFVEKPNR RLAEEYVSSG NHFWNSGMFL FKASTYLCEL KKYRPDIYDA CESAMSTSYH
DLDFIRLSEE SFKGCPAESI DFAVMEKTEC CVVYPLNIGR SDVGSWQSLW NISEKTETGD
VCKGDVLTYN TKNNYIYSDS TLVAAIGIED VVVIQTKDAI LVSKKSEVQN VKKIVDMLKH
QNRTEHVTHR EVFRPWGKFD AIDQGDRYKV KKIIVKPGEG LSLRMHHHRS EHWIVLSGTA
KVTLNNEIKL ITANESIYIP LGAVYSLENP GVIPLNLIEV SSGDYLGEDD MVRQKERYRN
ED
//