ID Q5WUZ2_LEGPL Unreviewed; 374 AA.
AC Q5WUZ2;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=Intermembrane phospholipid transport system permease protein MlaE {ECO:0000256|ARBA:ARBA00020857};
GN OrderedLocusNames=lpl2025 {ECO:0000313|EMBL:CAH16265.1};
OS Legionella pneumophila (strain Lens).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=297245 {ECO:0000313|EMBL:CAH16265.1, ECO:0000313|Proteomes:UP000002517};
RN [1] {ECO:0000313|EMBL:CAH16265.1, ECO:0000313|Proteomes:UP000002517}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lens {ECO:0000313|EMBL:CAH16265.1,
RC ECO:0000313|Proteomes:UP000002517};
RX PubMed=15467720; DOI=10.1038/ng1447;
RA Cazalet C., Rusniok C., Bruggemann H., Zidane N., Magnier A., Ma L.,
RA Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J.,
RA Glaser P., Buchrieser C.;
RT "Evidence in the Legionella pneumophila genome for exploitation of host
RT cell functions and high genome plasticity.";
RL Nat. Genet. 36:1165-1173(2004).
CC -!- FUNCTION: Part of the ABC transporter complex MlaFEDB, which is
CC involved in a phospholipid transport pathway that maintains lipid
CC asymmetry in the outer membrane by retrograde trafficking of
CC phospholipids from the outer membrane to the inner membrane. Probably
CC responsible for the translocation of the substrate across the membrane.
CC {ECO:0000256|ARBA:ARBA00002460}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (MlaF),
CC two transmembrane proteins (MlaE), two cytoplasmic solute-binding
CC proteins (MlaB) and six periplasmic solute-binding proteins (MlaD).
CC {ECO:0000256|ARBA:ARBA00011380}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|RuleBase:RU362044}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU362044}.
CC -!- SIMILARITY: Belongs to the MlaE permease family.
CC {ECO:0000256|RuleBase:RU362044}.
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DR EMBL; CR628337; CAH16265.1; -; Genomic_DNA.
DR RefSeq; WP_011216005.1; NC_006369.1.
DR AlphaFoldDB; Q5WUZ2; -.
DR KEGG; lpf:lpl2025; -.
DR LegioList; lpl2025; -.
DR HOGENOM; CLU_045686_0_0_6; -.
DR Proteomes; UP000002517; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR InterPro; IPR003453; ABC_MlaE_roteobac.
DR InterPro; IPR030802; Permease_MalE.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00056; MlaE family lipid ABC transporter permease subunit; 1.
DR PANTHER; PTHR30188:SF3; ABC TRANSPORTER PERMEASE PROTEIN; 1.
DR PANTHER; PTHR30188; ABC TRANSPORTER PERMEASE PROTEIN-RELATED; 1.
DR Pfam; PF02405; MlaE; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU362044};
KW Cell membrane {ECO:0000256|RuleBase:RU362044};
KW Membrane {ECO:0000256|RuleBase:RU362044};
KW Transmembrane {ECO:0000256|RuleBase:RU362044};
KW Transmembrane helix {ECO:0000256|RuleBase:RU362044}.
FT TRANSMEM 168..187
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362044"
FT TRANSMEM 199..222
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362044"
FT TRANSMEM 261..283
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362044"
FT TRANSMEM 313..334
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362044"
FT TRANSMEM 354..372
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362044"
SQ SEQUENCE 374 AA; 41028 MW; 22909E5E938E4488 CRC64;
MEQASAQIVF EQKNATYQCC GSWSVLTLEG LPKKFITGSL PDSQQITING EKISAFDSAG
ALALKKCIDE LKKRNNQIEL VNFSDSQQQM LELIESKQEI LSYQLPAVSK EGVLYQIGKE
SENKLHQVDG LIILIGDLST RLFEAFAYWR RFHLPSIVSV IDSAGLKALP IIGLLSFLIG
VVLAYQMGLQ LETYGANIFI AYLSGMAIFR EFGPLITAII VAGRTSSSFT AQIGSMKINE
EVDAILTMGL SPTELLVLPK VLGLLIVFPL LIFWADVFSI WGAMIMSKNM LNIGFEDFLS
RLRDSVGLNQ MMLGLYKAPA FSILIALVGC FQGFRVESSA DSIGSQTTKS VVQALFLIII
ADAAFSIAYS WMGL
//
