ID GPDA_LEGPA Reviewed; 329 AA.
AC Q5X2Y0;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 29-MAY-2013, entry version 71.
DE RecName: Full=Glycerol-3-phosphate dehydrogenase [NAD(P)+];
DE EC=1.1.1.94;
DE AltName: Full=NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
GN Name=gpsA; OrderedLocusNames=lpp2257;
OS Legionella pneumophila (strain Paris).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=297246;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Paris;
RX PubMed=15467720; DOI=10.1038/ng1447;
RA Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L.,
RA Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F.,
RA Etienne J., Glaser P., Buchrieser C.;
RT "Evidence in the Legionella pneumophila genome for exploitation of
RT host cell functions and high genome plasticity.";
RL Nat. Genet. 36:1165-1173(2004).
CC -!- CATALYTIC ACTIVITY: sn-glycerol 3-phosphate + NAD(P)(+) =
CC glycerone phosphate + NAD(P)H.
CC -!- PATHWAY: Membrane lipid metabolism; glycerophospholipid
CC metabolism.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the NAD-dependent glycerol-3-phosphate
CC dehydrogenase family.
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DR EMBL; CR628336; CAH13410.1; -; Genomic_DNA.
DR RefSeq; YP_124568.1; NC_006368.1.
DR ProteinModelPortal; Q5X2Y0; -.
DR STRING; 297246.lpp2257; -.
DR EnsemblBacteria; CAH13410; CAH13410; lpp2257.
DR GeneID; 3118553; -.
DR KEGG; lpp:lpp2257; -.
DR PATRIC; 22325073; VBILegPne27771_2575.
DR LegioList; lpp2257; -.
DR eggNOG; COG0240; -.
DR HOGENOM; HOG000246854; -.
DR KO; K00057; -.
DR OMA; DVIGCEI; -.
DR ProtClustDB; PRK00094; -.
DR BioCyc; LPNE297246:GCO9-2911-MONOMER; -.
DR UniPathway; UPA00940; -.
DR GO; GO:0009331; C:glycerol-3-phosphate dehydrogenase complex; IEA:InterPro.
DR GO; GO:0047952; F:glycerol-3-phosphate dehydrogenase [NAD(P)+] activity; IEA:HAMAP.
DR GO; GO:0004367; F:glycerol-3-phosphate dehydrogenase [NAD+] activity; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0046167; P:glycerol-3-phosphate biosynthetic process; IEA:HAMAP.
DR GO; GO:0046168; P:glycerol-3-phosphate catabolic process; IEA:InterPro.
DR GO; GO:0006650; P:glycerophospholipid metabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:HAMAP.
DR Gene3D; 1.10.1040.10; -; 1.
DR Gene3D; 3.40.50.720; -; 1.
DR HAMAP; MF_00394; NAD_Glyc3P_dehydrog; 1; -.
DR InterPro; IPR008927; 6-PGluconate_DH_C-like.
DR InterPro; IPR013328; DH_multihelical.
DR InterPro; IPR006168; G3P_DH_NAD-dep.
DR InterPro; IPR006109; G3P_DH_NAD-dep_C.
DR InterPro; IPR011128; G3P_DH_NAD-dep_N.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR PANTHER; PTHR11728; PTHR11728; 1.
DR Pfam; PF07479; NAD_Gly3P_dh_C; 1.
DR Pfam; PF01210; NAD_Gly3P_dh_N; 1.
DR PIRSF; PIRSF000114; Glycerol-3-P_dh; 1.
DR PRINTS; PR00077; GPDHDRGNASE.
DR SUPFAM; SSF48179; 6DGDH_C_like; 1.
DR PROSITE; PS00957; NAD_G3PDH; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Lipid biosynthesis; Lipid metabolism;
KW NAD; Oxidoreductase; Phospholipid biosynthesis;
KW Phospholipid metabolism.
FT CHAIN 1 329 Glycerol-3-phosphate dehydrogenase
FT [NAD(P)+].
FT /FTId=PRO_0000137978.
FT NP_BIND 10 15 NAD (By similarity).
FT REGION 253 254 Substrate binding (By similarity).
FT ACT_SITE 189 189 Proton acceptor (By similarity).
FT BINDING 105 105 NAD; via amide nitrogen (By similarity).
FT BINDING 105 105 Substrate (By similarity).
FT BINDING 138 138 NAD; via amide nitrogen (By similarity).
FT BINDING 253 253 NAD (By similarity).
FT BINDING 279 279 NAD (By similarity).
SQ SEQUENCE 329 AA; 35435 MW; 21BF1B6FD9430557 CRC64;
MNKKTIAMLG AGSWGTAVAI HLAKIGHKTL LWSHNPQHVA LMAEQHSNPA YLPGIPFPEN
LIPSDDLIEC VQLADYVIIA VPSHAFAEII NKIPKPTQGL AWLTKGVDPA SHQLLSQLVA
SRFGVDFPIA VISGPSFAKE VARFLPTALT LASNNTNYQK KMHQLFHHDN IRVYLSDDLI
GVQLCGAVKN ILAIACGISD GLGYGANAKA ALITRGLAEM TRLGLSMGAR QDTFLGLAGV
GDLVLTCTDD QSRNRRFGLL LGREVPIPEA EHQIGQVVEG KHNAAQICAI ANKNKVEMPI
CEQINALLHG IVHAQQAVNN LMSRPAKEE
//
