ID Q5XAV4_STRP6 Unreviewed; 575 AA.
AC Q5XAV4;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 117.
DE SubName: Full=Two-component sensor kinase yesM {ECO:0000313|EMBL:AAT87459.1};
DE EC=2.7.3.- {ECO:0000313|EMBL:AAT87459.1};
GN OrderedLocusNames=M6_Spy1324 {ECO:0000313|EMBL:AAT87459.1};
OS Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=286636 {ECO:0000313|EMBL:AAT87459.1, ECO:0000313|Proteomes:UP000001167};
RN [1] {ECO:0000313|EMBL:AAT87459.1, ECO:0000313|Proteomes:UP000001167}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-946 / MGAS10394 {ECO:0000313|Proteomes:UP000001167};
RX PubMed=15272401; DOI=10.1086/422697;
RA Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E.,
RA Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.;
RT "Progress toward characterization of the group A Streptococcus metagenome:
RT complete genome sequence of a macrolide-resistant serotype M6 strain.";
RL J. Infect. Dis. 190:727-738(2004).
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DR EMBL; CP000003; AAT87459.1; -; Genomic_DNA.
DR AlphaFoldDB; Q5XAV4; -.
DR KEGG; spa:M6_Spy1324; -.
DR HOGENOM; CLU_020473_6_3_9; -.
DR Proteomes; UP000001167; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR010559; Sig_transdc_His_kin_internal.
DR PANTHER; PTHR34220; SENSOR HISTIDINE KINASE YPDA; 1.
DR PANTHER; PTHR34220:SF7; SENSOR HISTIDINE KINASE YPDA; 1.
DR Pfam; PF06580; His_kinase; 1.
DR SMART; SM00304; HAMP; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR PROSITE; PS50885; HAMP; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AAT87459.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AAT87459.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 284..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 307..360
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
SQ SEQUENCE 575 AA; 66764 MW; D21D22771DB3BCEB CRC64;
MMSVKTLGRY VTNHFKQGFL INRLMKLYSL LIVSFFTLAA IGLSSYSISS TYKRVDAEAQ
MRLEETLGRL QSQNDITLRV LDQLVGRSED YHNLYQYMTL TPNQYFSNVF EDWEKGKDTV
LFSEEVRRLF DLYPDVTSMT LLLEDSSAYL YADKVIKTGR LLYSKPEKVT GNVLVRSIRN
PESGDVTGRL YLTFDKPPTL VETQQDHYLA TFAFDYYGRK LFHQGGRRFP HLEAEVKKAI
KADRAADLSN LSKAYRMQYN RSGDLLAYVA VRKSYLLAEA VRTVFVYGLV SLLLAWLLLQ
LLFRVFRNYI QQVSEITDTV EMVAAGDLSL TIDNSHMELE LYHISEAINQ MLASIKAYID
EVYVLEVEQR DAQMRALQSQ INPHFLYNTL EYIRMYALSC QQEELADVIY AFASLLRNNI
SQDKMTTLKE ELAFCEKYIY LYQMRYPDSF AYHVKIDESI ADLAIPKFVI QPLVENYFVH
GIDYSRHDNA LSIKALDETD HLLIQVLDNG RGISQERLAD MKRRLQEHQT TGNSSIGLQN
VYLRLFHHFR DRVSWSMAKE PNDGFIIQIR IRKDA
//
