ID   Q5XE55_STRP6            Unreviewed;       666 AA.
AC   Q5XE55;
DT   23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT   23-NOV-2004, sequence version 1.
DT   27-MAR-2024, entry version 92.
DE   RecName: Full=V-type ATP synthase subunit I {ECO:0000256|RuleBase:RU361189};
GN   OrderedLocusNames=M6_Spy0173 {ECO:0000313|EMBL:AAT86308.1};
OS   Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=286636 {ECO:0000313|EMBL:AAT86308.1, ECO:0000313|Proteomes:UP000001167};
RN   [1] {ECO:0000313|EMBL:AAT86308.1, ECO:0000313|Proteomes:UP000001167}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-946 / MGAS10394 {ECO:0000313|Proteomes:UP000001167};
RX   PubMed=15272401; DOI=10.1086/422697;
RA   Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E.,
RA   Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.;
RT   "Progress toward characterization of the group A Streptococcus metagenome:
RT   complete genome sequence of a macrolide-resistant serotype M6 strain.";
RL   J. Infect. Dis. 190:727-738(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; CP000003; AAT86308.1; -; Genomic_DNA.
DR   RefSeq; WP_011184112.1; NC_006086.1.
DR   AlphaFoldDB; Q5XE55; -.
DR   KEGG; spa:M6_Spy0173; -.
DR   HOGENOM; CLU_025558_1_0_9; -.
DR   Proteomes; UP000001167; Chromosome.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrolase {ECO:0000313|EMBL:AAT86308.1};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        381..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        419..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        456..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        489..511
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        517..541
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        572..593
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        599..619
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          121..158
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   666 AA;  75924 MW;  C2E3B64A5E313261 CRC64;
     MAISQMKKLA MVFEKDYLDL VLKTLQQSQL VEVRDMKQLK HWQDAFNKGN VKLPQIVQYD
     LTHQKPLLDD EALQYLLQSQ QELENGLASL SAFLPPIGKL TALRQKTPSL SFKQFEERHR
     QQAAQTALKM MSQKIERLEQ LQNKIDQLTE YCQELEKWRS LTVLPQDLAQ FHFLSARVGT
     IPSTANDHFY HQLKQHKGLF IEEVYHTEFE YGLVLFWQAQ DTIHLQKYQF KPLLYKEQLL
     PSEQLRINKE LLTNWLAEKD SLLKELRQSQ KILAQLQVEI DYVLSQYQRQ QTKKQLLGTR
     HLIALEGWIE ADSVNQLKGL MTKTLGDMFY LDSYDVTPDD WEDVPIKLRN HRYIAPFELV
     TEMYALPKYQ EKDPTPFLAP LYLTFFGMMV ADLGYGLLLY AVTLAALVFF NLQKTSKRLV
     TFFNILAISV AIWGLIYGSF FGFDLPVALL STKTDVITIL VVSLLFGFVT LIFGLLLGAW
     QQVRMKAYAT AYTSSLAWTF ILLGLLLFIL GKNVSGLAYL SVIGKWLALG NAFGILVVSL
     LKSKSLLGLG SGLYNLYGIS SYLSDLVSFT RLMALGLSGA SIGAAFNMIV GIFPPVTRFT
     VGIFIFILLH AINIFLSMLS GYVHGARLIF VEFFGKFYEG GGKAFNPLKL ADNYVNVNEE
     TDLEDN
//