ID Q5XG33_XENLA Unreviewed; 646 AA.
AC Q5XG33;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Embryonal Fyn-associated substrate L homeolog {ECO:0000313|RefSeq:NP_001088375.1};
DE SubName: Full=LOC495224 protein {ECO:0000313|EMBL:AAH84637.1};
GN Name=efs.L {ECO:0000313|RefSeq:NP_001088375.1,
GN ECO:0000313|Xenbase:XB-GENE-865961};
GN Synonyms=efs {ECO:0000313|RefSeq:NP_001088375.1,
GN ECO:0000313|Xenbase:XB-GENE-865961}, LOC495224
GN {ECO:0000313|EMBL:AAH84637.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH84637.1};
RN [1] {ECO:0000313|RefSeq:NP_001088375.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH84637.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH84637.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001088375.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CAS family. {ECO:0000256|ARBA:ARBA00007848}.
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DR EMBL; BC084637; AAH84637.1; -; mRNA.
DR RefSeq; NP_001088375.1; NM_001094906.1.
DR GeneID; 495224; -.
DR KEGG; xla:495224; -.
DR AGR; Xenbase:XB-GENE-865961; -.
DR CTD; 495224; -.
DR Xenbase; XB-GENE-865961; efs.L.
DR OrthoDB; 3030146at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 495224; Expressed in neurula embryo and 16 other cell types or tissues.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd11571; FAT-like_EFS_C; 1.
DR CDD; cd12003; SH3_EFS; 1.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR021901; CAS_C.
DR InterPro; IPR037362; CAS_fam.
DR InterPro; IPR035747; EFS_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10654; CAS SCAFFOLDING PROTEIN; 1.
DR PANTHER; PTHR10654:SF14; EMBRYONAL FYN-ASSOCIATED SUBSTRATE; 1.
DR Pfam; PF12026; CAS_C; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..62
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 88..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..107
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..514
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 646 AA; 70458 MW; AA6F5C1BE12E2ACB CRC64;
MAQLAQALYD NAAESPEELS FRRGDVMLVL ERDDPSLGGW WRCSLRGQQG IAPGNRLQLI
PETPQQESEY QAPRFLGVNV DAGKLQKYEK GAQEKREEPK NEEEPENQTG AEVYQVPSIA
RLRLSGQPAN AQDDIYNSPR LVGSCIEQPL EVYDTPSALR KDPLSTLDTY DSPALRVKAA
DSAAQVPEEI PEDIYDVPPT FNKSPSDDEE DEGVYSMPSN LKRVSGLQNL YEAPEDILSS
GHLPEILPPP PAQRLSVCST GSTRSADSAG SRESNIPPLS IWEPRNDGTC TMEGLRMLHQ
ELQVSIAPVL AGAEKSAEPG GQEDSGTTKK VLGALRDFLV MAHVAGLRSC QASDPALHRE
LSVHLDQLEN AARELLDKGS ERPLIQLIQE HSNCFVRLVS ANAGLLFPRP RLSSSESLSR
RPLPALPTAS PAIQRKGSIQ DRPLPPPPTL QHVASDPSDD IHSEYERIQC RDNHYVHLQG
SITAQNISKR KDRQKDTGQG STLEEREVDP FPEASEEDRH LLHFYATQSH SHLQTLLSCV
GTFLGSASSQ PPRVFVGHGK QLVIAAHKLV FIGDTLGRLL SCPQLQTRLA GEGAALCQAL
KDVVLATKEA ATLYPAPAAL KAMAGTVSVL CTCAHSFTHL LQHLAT
//
