ID Q5XI24_RAT Unreviewed; 498 AA.
AC Q5XI24;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 150.
DE SubName: Full=Matrilin 1 {ECO:0000313|Ensembl:ENSRNOP00000014666.3};
GN Name=Matn1 {ECO:0000313|Ensembl:ENSRNOP00000014666.3,
GN ECO:0000313|RGD:1359410};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000014666.3, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000014666.3, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000014666.3,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000014666.3}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000014666.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001006980.1; NM_001006979.1.
DR AlphaFoldDB; Q5XI24; -.
DR SMR; Q5XI24; -.
DR STRING; 10116.ENSRNOP00000014666; -.
DR PaxDb; 10116-ENSRNOP00000014666; -.
DR Ensembl; ENSRNOT00000014666.4; ENSRNOP00000014666.3; ENSRNOG00000010932.4.
DR GeneID; 297894; -.
DR KEGG; rno:297894; -.
DR UCSC; RGD:1359410; rat.
DR AGR; RGD:1359410; -.
DR CTD; 4146; -.
DR RGD; 1359410; Matn1.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000159638; -.
DR HOGENOM; CLU_008905_7_0_1; -.
DR OMA; ICIEEDP; -.
DR OrthoDB; 1453590at2759; -.
DR TreeFam; TF330078; -.
DR Reactome; R-RNO-3000178; ECM proteoglycans.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000010932; Expressed in kidney and 2 other cell types or tissues.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR GO; GO:0031012; C:extracellular matrix; ISO:RGD.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0002062; P:chondrocyte differentiation; ISO:RGD.
DR GO; GO:0003429; P:growth plate cartilage chondrocyte morphogenesis; ISO:RGD.
DR GO; GO:0030500; P:regulation of bone mineralization; ISO:RGD.
DR CDD; cd01475; vWA_Matrilin; 1.
DR Gene3D; 1.20.5.30; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036337; Matrilin_cc_sf.
DR InterPro; IPR019466; Matrilin_coiled-coil_trimer.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020:SF16; CARTILAGE MATRIX PROTEIN; 1.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF10393; Matrilin_ccoil; 1.
DR Pfam; PF00092; VWA; 2.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00181; EGF; 1.
DR SMART; SM00179; EGF_CA; 1.
DR SMART; SM01279; Matrilin_ccoil; 1.
DR SMART; SM00327; VWA; 2.
DR SUPFAM; SSF58002; Chicken cartilage matrix protein; 1.
DR SUPFAM; SSF53300; vWA-like; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50234; VWFA; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..498
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014587133"
SQ SEQUENCE 498 AA; 54309 MW; A087EE3EC7A3C2D3 CRC64;
MKVTSGPAFG LCSLMLLLLL QVPGSLGLAS QPRGHLCRTR PTDLVFVVDS SRSVRPVEFE
KVKVFLSQVI KSLDVGPNAT RVGLVNYAST VKPEFPLRAH TSKASLLQAV HRIQPLSTGT
MTGLALQFAI TKALSDAEGG RSRSSDISKV VIVVTDGRPQ DSVRDVSERA RASGIELFAI
GVGRVDKATL RQIASEPQDE HVDYVESYNV IEKLAKKFQE AFCVSDLCAT GDHYCEQVCV
SSPGSYTCAC HEGFTLNSDG KTCNVCRGGG NGSATDLVFL IDGSKSVRPE NFELVKKFIN
QIVDTLDVSD RLAQVGLVQY SSSIRQEFPL GRFHTKKDIK AAVRNMSYME KGTMTGAALK
YLIDNSFTVS SGARPGAQKV GIVFTDGRSQ DYINDAARKA KDLGFKMFAV GVGNAVEEEL
REIASEPVAD HYFYTADFKT INQIGKKLQK KICVEEEDPC ACESIVRFEA KVEGLLQDLT
RKLEAVSKRL AVLENRVI
//
