ID EIPR1_DANRE Reviewed; 387 AA.
AC Q5XJP1;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE RecName: Full=EARP-interacting protein homolog {ECO:0000250|UniProtKB:Q5PPK9};
GN Name=eipr1 {ECO:0000250|UniProtKB:Q5PPK9}; ORFNames=zgc:101720;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May act as a component of endosomal retrieval machinery that
CC is involved in protein transport from early endosomes to either
CC recycling endosomes or the trans-Golgi network.
CC {ECO:0000250|UniProtKB:Q53HC9}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
CC {ECO:0000250|UniProtKB:Q53HC9}.
CC -!- SIMILARITY: Belongs to the WD repeat EIPR1 family. {ECO:0000305}.
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DR EMBL; BC083257; AAH83257.1; -; mRNA.
DR RefSeq; NP_001006065.1; NM_001006065.1.
DR AlphaFoldDB; Q5XJP1; -.
DR SMR; Q5XJP1; -.
DR STRING; 7955.ENSDARP00000063737; -.
DR PaxDb; 7955-ENSDARP00000063737; -.
DR GeneID; 450045; -.
DR KEGG; dre:450045; -.
DR AGR; ZFIN:ZDB-GENE-041010-167; -.
DR CTD; 7260; -.
DR ZFIN; ZDB-GENE-041010-167; eipr1.
DR eggNOG; KOG1007; Eukaryota.
DR InParanoid; Q5XJP1; -.
DR OrthoDB; 167212at2759; -.
DR PhylomeDB; Q5XJP1; -.
DR PRO; PR:Q5XJP1; -.
DR Proteomes; UP000000437; Chromosome 17.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0032456; P:endocytic recycling; ISS:UniProtKB.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR040323; EIPR1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR14205:SF15; EARP AND GARP COMPLEX-INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR14205; WD-REPEAT PROTEIN; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..387
FT /note="EARP-interacting protein homolog"
FT /id="PRO_0000051303"
FT REPEAT 132..172
FT /note="WD 1"
FT REPEAT 182..222
FT /note="WD 2"
FT REPEAT 226..266
FT /note="WD 3"
FT REPEAT 270..310
FT /note="WD 4"
FT REPEAT 345..385
FT /note="WD 5"
FT REGION 309..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 387 AA; 43588 MW; A7E25DFC77CF4368 CRC64;
MEDDAPVIYG LEFQARALTA QTAETDAIRF LVGTQSLKFD NQIHIIDFDD ENNMINKSVL
LHDAGEIWHI SGSPADKAVL TTCYNKTSES RVLTCAAVWR MPPEWESGNH ESPDDSSNNP
QTLELLCHLD NSAHGSMACV LWEPMGDGKR VISLAENHVL LWDLQESSAK ATISSSATLE
GKGQLKFTAG KWSPHHNCTQ LATANDTAIR GWDLRSMSQI YCIENAHGQL VRDLDFNPNK
QYYLASCGDD CKVKFWDVRH ISEPVKCLEE HSHWVWSVRY NHSHDQLLLT ASSDSRVILS
NMVSISSEPF GHLVDDDDLS DPEENQQEDK GKEPLQDSII STYEEHEDSV YAVEWSAADP
WLFASLSYDG RLVINRVPRA LKYRILL
//
