ID   Q5Y1J3_9HEPC            Unreviewed;       134 AA.
AC   Q5Y1J3;
DT   23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT   23-NOV-2004, sequence version 1.
DT   24-JAN-2024, entry version 60.
DE   SubName: Full=NS3 {ECO:0000313|EMBL:AAU44924.1};
DE   Flags: Fragment;
OS   Hepacivirus hominis.
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
OC   Amarillovirales; Flaviviridae; Hepacivirus.
OX   NCBI_TaxID=3052230 {ECO:0000313|EMBL:AAU44924.1};
RN   [1] {ECO:0000313|EMBL:AAU44924.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=1.5.04-15 {ECO:0000313|EMBL:AAU44924.1};
RX   PubMed=15611288; DOI=10.1084/jem.20041006;
RA   Timm J., Lauer G.M., Kavanagh D.G., Sheridan I., Kim A.Y., Lucas M.,
RA   Pillay T., Ouchi K., Reyor L.L., Zur Wiesch J.S., Gandhi R.T., Chung R.T.,
RA   Bhardwaj N., Klenerman P., Walker B.D., Allen T.M.;
RT   "CD8 epitope escape and reversion in acute HCV infection.";
RL   J. Exp. Med. 200:1593-1604(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR   EMBL; AY712893; AAU44924.1; -; Genomic_RNA.
DR   euHCVdb; AY712893; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011492; Flavi_DEAD.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF07652; Flavi_DEAD; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840}.
FT   DOMAIN          4..50
FT                   /note="Non-structural protein NS3-like DEAD box helicase
FT                   flavivirus"
FT                   /evidence="ECO:0000259|Pfam:PF07652"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAU44924.1"
FT   NON_TER         134
FT                   /evidence="ECO:0000313|EMBL:AAU44924.1"
SQ   SEQUENCE   134 AA;  13879 MW;  F18D6EFD6075701C CRC64;
     GGAYDIIICD ECHSTDSTTI LGIGTVLDQA ETAGARLVVL ATATPPGSVT VPHPNIEEVG
     LSNIGEIPFY GKAIPIETIK GGRHLIFCHS KKKCDEFAAK LSGLGINAVA YYRGLDVSVI
     PTSGDVVVVA TDAL
//