ID Q5YKJ0_PICAN Unreviewed; 439 AA.
AC Q5YKJ0;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Vps4p {ECO:0000313|EMBL:AAR28448.1};
GN Name=VPS4 {ECO:0000313|EMBL:AAR28448.1};
OS Pichia angusta (Yeast) (Hansenula polymorpha).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Ogataea.
OX NCBI_TaxID=870730 {ECO:0000313|EMBL:AAR28448.1};
RN [1] {ECO:0000313|EMBL:AAR28448.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CBS 4732 {ECO:0000313|EMBL:AAR28448.1};
RA Leao-Helder A.N., Krikken A.M., Lunenborg M.G.J., Kiel J.A.K.W.,
RA van der Klei I.J., Veenhuis M.;
RT "Hansenula polymorpha Tup1p is important for selective peroxisome
RT degradation.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the AAA ATPase family.
CC {ECO:0000256|ARBA:ARBA00006914, ECO:0000256|RuleBase:RU003651}.
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DR EMBL; AY383553; AAR28448.1; -; Genomic_DNA.
DR AlphaFoldDB; Q5YKJ0; -.
DR PhylomeDB; Q5YKJ0; -.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd02678; MIT_VPS4; 1.
DR CDD; cd19521; RecA-like_VPS4; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR007330; MIT_dom.
DR InterPro; IPR036181; MIT_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015415; Spast_Vps4_C.
DR InterPro; IPR045253; VPS4_MIT.
DR PANTHER; PTHR23074; AAA DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR23074:SF83; VESICLE-FUSING ATPASE; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF04212; MIT; 1.
DR Pfam; PF09336; Vps4_C; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00745; MIT; 1.
DR SUPFAM; SSF116846; MIT domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00674; AAA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003651};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003651}.
FT DOMAIN 4..81
FT /note="MIT"
FT /evidence="ECO:0000259|SMART:SM00745"
FT DOMAIN 164..299
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 76..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 439 AA; 48915 MW; C0BAD8AA6DB7A735 CRC64;
MSSASEFLDK GVDLVKKAIE ADSTSKYDEA YRLYYNGLDY LMLALKYEKN PKSKETIRSK
FTEYLSRAEQ LKEYLDKKQQ QDQTGEASAT SGSVKAKKTS GGEDDDNDSD TKKLRGALAS
SILSERPNVQ WSDIAGLELA KEALKEAVIL PVKFPHLFRG KRKPVSGILL YGPPGTGKSY
LAKAVATEAN STFFSVSSSD LVSKWMGESE RLVKQLFTMA REQKPAIIFI DEVDALCGPR
GEGESEASRR IKTELLVQMN GVGNDSDGVL VLGATNIPWQ LDAAIRRRFE RRIYIPLPDQ
EARVEMFKLN IGDTPCSLTT QDYHTLAQMT DGYSGHDVSV VVKDALMQPI RKIQMATHFK
KVVSTDEEGR ELVQYTPCSP GDSEAIEMSW LDLDGEQLKE PELGIKDFIK AIKTNKPTVN
QKDLEKFIEF TNDFGSEGN
//
