ID Q5YWI2_NOCFA Unreviewed; 523 AA.
AC Q5YWI2;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE SubName: Full=Putative oxidoreductase {ECO:0000313|EMBL:BAD57459.1};
GN OrderedLocusNames=NFA_26120 {ECO:0000313|EMBL:BAD57459.1};
OS Nocardia farcinica (strain IFM 10152).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=247156 {ECO:0000313|EMBL:BAD57459.1, ECO:0000313|Proteomes:UP000006820};
RN [1] {ECO:0000313|EMBL:BAD57459.1, ECO:0000313|Proteomes:UP000006820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IFM 10152 {ECO:0000313|EMBL:BAD57459.1,
RC ECO:0000313|Proteomes:UP000006820};
RX PubMed=15466710; DOI=10.1073/pnas.0406410101;
RA Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K.,
RA Shiba T., Hattori M.;
RT "The complete genomic sequence of Nocardia farcinica IFM 10152.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
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DR EMBL; AP006618; BAD57459.1; -; Genomic_DNA.
DR RefSeq; WP_011209144.1; NC_006361.1.
DR AlphaFoldDB; Q5YWI2; -.
DR STRING; 247156.NFA_26120; -.
DR GeneID; 61133353; -.
DR KEGG; nfa:NFA_26120; -.
DR eggNOG; COG2303; Bacteria.
DR HOGENOM; CLU_002865_7_2_11; -.
DR OrthoDB; 9785276at2; -.
DR Proteomes; UP000006820; Chromosome.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR11552:SF147; CHOLINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Reference proteome {ECO:0000313|Proteomes:UP000006820}.
FT DOMAIN 250..264
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
FT ACT_SITE 462
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-1"
FT ACT_SITE 504
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-1"
SQ SEQUENCE 523 AA; 56695 MW; 7553DEFADB36647C CRC64;
MAADYVVVGT GSAGAVVAHR LSEDSGTRVV ALEAGPPDKN KFAHIPAGFA KLFRSELDWD
YLTEPQPALD GRRIYWPRGR MFGGSSSMNA MMWVRGFRAD YDEWALLAGD EWGFAAAVEQ
YRRIENVQDA QYPDEGTGGP IHVEHQRSPR ASTAAFLTAV QESGFPVEPP NRPQPKGFSQ
TMVTQHGGRR WSTADAYLKP AMRRPNLTVL PEALATRVLF EGTRAVGVEY RRGTETFVVR
ARREVVLCGG AINSPQLLML SGVGDADELA RHGIPVVRHA PEVGANLQDH LVAGLGYSVE
GDSLFAAEKP KELLNYLLRH RGMLTSNVGE AYGFVRSRPD LEQPDLELVY APAPFYYEGL
LDPTEHGVIL ATVLLRPESR GRIALASADP TAKPVIDPRY LSDSDGVDRA AILSGLRTCA
RIAEAPALKA VLGDLIYPPK APADLEAAIE LALTGYSHTL YHPVGTCRMG TDPVSVVDPQ
LRVRGVAGLR VADASVMPLL VRGHTHAPSV FVGEQAARFL RAG
//
