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Database: UniProt
Entry: Q5ZJA7_CHICK
LinkDB: Q5ZJA7_CHICK
Original site: Q5ZJA7_CHICK 
ID   Q5ZJA7_CHICK            Unreviewed;      1016 AA.
AC   Q5ZJA7; E1C4Z4;
DT   23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT   23-NOV-2004, sequence version 1.
DT   30-AUG-2017, entry version 87.
DE   SubName: Full=Oxoglutarate dehydrogenase {ECO:0000313|Ensembl:ENSGALP00000028857};
GN   Name=OGDH {ECO:0000313|Ensembl:ENSGALP00000028857};
GN   ORFNames=RCJMB04_19j12 {ECO:0000313|EMBL:CAG32186.1};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|EMBL:CAG32186.1};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00000028857, ECO:0000313|Proteomes:UP000000539}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000028857,
RC   ECO:0000313|Proteomes:UP000000539};
RX   PubMed=15592404; DOI=10.1038/nature03154;
RG   International Chicken Genome Sequencing Consortium;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
RA   Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
RA   Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
RA   Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
RA   Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
RA   Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
RA   Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
RA   Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
RA   Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
RA   Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
RA   van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
RA   Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
RA   Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
RA   Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
RA   Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
RA   Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
RA   Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
RA   Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
RA   King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
RA   Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
RA   Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
RA   Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
RA   Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
RA   Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
RA   Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
RA   Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
RA   Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
RA   Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
RA   Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
RA   Mardis E.R., Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide
RT   unique perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
RN   [2] {ECO:0000313|EMBL:CAG32186.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CB {ECO:0000313|EMBL:CAG32186.1};
RC   TISSUE=Bursa {ECO:0000313|EMBL:CAG32186.1};
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J.,
RA   Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M.,
RA   Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
RN   [3] {ECO:0000313|Ensembl:ENSGALP00000028857}
RP   IDENTIFICATION.
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000028857};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AADN04000411; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJ720527; CAG32186.1; -; mRNA.
DR   RefSeq; NP_001026553.1; NM_001031382.1.
DR   UniGene; Gga.7238; -.
DR   STRING; 9031.ENSGALP00000028857; -.
DR   Ensembl; ENSGALT00000029510; ENSGALP00000028857; ENSGALG00000014155.
DR   GeneID; 426429; -.
DR   KEGG; gga:426429; -.
DR   CTD; 4967; -.
DR   eggNOG; KOG0450; Eukaryota.
DR   eggNOG; COG0567; LUCA.
DR   GeneTree; ENSGT00530000063092; -.
DR   HOVERGEN; HBG001892; -.
DR   KO; K00164; -.
DR   OMA; IDMVCYR; -.
DR   OrthoDB; EOG091G025G; -.
DR   TreeFam; TF300695; -.
DR   Reactome; R-GGA-389661; Glyoxylate metabolism and glycine degradation.
DR   Reactome; R-GGA-71064; Lysine catabolism.
DR   Reactome; R-GGA-71403; Citric acid cycle (TCA cycle).
DR   Proteomes; UP000000539; Chromosome 22.
DR   Bgee; ENSGALG00000014155; -.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0045252; C:oxoglutarate dehydrogenase complex; IBA:GO_Central.
DR   GO; GO:0034602; F:oxoglutarate dehydrogenase (NAD+) activity; IEA:Ensembl.
DR   GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IBA:GO_Central.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0021695; P:cerebellar cortex development; IEA:Ensembl.
DR   GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
DR   GO; GO:0061034; P:olfactory bulb mitral cell layer development; IEA:Ensembl.
DR   GO; GO:0021860; P:pyramidal neuron development; IEA:Ensembl.
DR   GO; GO:0021756; P:striatum development; IEA:Ensembl.
DR   GO; GO:0022028; P:tangential migration from the subventricular zone to the olfactory bulb; IEA:Ensembl.
DR   GO; GO:0021794; P:thalamus development; IEA:Ensembl.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
DR   InterPro; IPR032106; 2-oxogl_dehyd_N.
DR   InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR031717; KGD_C.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   PANTHER; PTHR23152; PTHR23152; 1.
DR   Pfam; PF16078; 2-oxogl_dehyd_N; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF16870; OxoGdeHyase_C; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   TIGRFAMs; TIGR00239; 2oxo_dh_E1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000539};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539}.
FT   DOMAIN      646    858       Transket_pyr. {ECO:0000259|SMART:
FT                                SM00861}.
SQ   SEQUENCE   1016 AA;  115181 MW;  04EB856D8C390DD4 CRC64;
     MFNLRTCAAK LRPLTASQTV KTVSQQRPAA PRTFHPIRCY SAPVAAEPFL SGTSSNYVEE
     MYYAWLENPK SVHKSWDIFF RNANAGAAPG TAYQSPPPLS SSLSTLSQAQ FLVQAQPNVD
     KLVEDHLAVQ SLIRAYQVRG HHIAKLDPLG ISCVNFDDAP VTVSPNVGFY GLDESDLDKV
     FHLPTTTFIG GNESALPLRE IIRRLEMAYC QHIGVEFMFI NDLEQCQWIR QKFETPGIMQ
     FTNEEKRTLL ARLVRSTRFE EFLHRKWSSE KRFGLEGCEV LIPALKTIID KSSEKGVDYV
     IMGMPHRGRL NVLANVIRKE LEQIFCQFDS KLEAADEGSG DVKYHLGMYH RRINRVTDRN
     ITLSLVANPS HLEAADPVVQ GKTKAEQFYC GDTEGKKVMS ILLHGDAAFA GQGIVYETFH
     LSDLPSYTTH GTVHVVVNNQ IGFTTDPRMA RSSPYPTDVA RVVNAPIFHV NADDPEAVVY
     VCNVAAEWRS TFHKDVVVDL VCYRRNGHNE MDEPMFTQPL MYKQIRKQKP VLQKYAELLI
     SQGVVNQPEY EEEIAKYDKI CEEAHARSKD EKILHIKHWL DSPWPGFFTL DGQPRSMSCP
     STGLNEEDLT HIGQVASSVP VEDFTIHGGL SRILKTRGEM VKNRTVDWAL AEYMAFGSLL
     KEGIHIRLSG QDVERGTFSH RHHVLHDQNV DKRTCIPMNH LWPNQAPYTV CNSSLSEYGV
     LGFELGFAMA SPNALVLWEA QFGDFHNTAQ CIIDQFICPG QAKWVRQNGI VLLLPHGMEG
     MGPEHSSARP ERFLQMCNDD PDVFPKLDDF DVRQLYDCNW IVVNCSTPAN FFHVLRRQIL
     LPFRKPLIIF TPKSLLRHPE ARSSFDDMLP GTNFLRVIPD GGPAAQSPQN VRRVLFCTGK
     VYYDLTRERK ARNMEADVAI TRVEQLSPFP FDLLQKEAQK YPNAELVWCQ EEHKNQGYYD
     YVKPRLRTTI NRAKPVWYAG REPAAAPATG NKKTHLTELQ RLLDTAFNLD AFKDLA
//
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