ID Q5ZJB6_CHICK Unreviewed; 734 AA.
AC Q5ZJB6;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 24-JAN-2024, entry version 91.
DE RecName: Full=Acylamino-acid-releasing enzyme {ECO:0000256|ARBA:ARBA00018421};
DE EC=3.4.19.1 {ECO:0000256|ARBA:ARBA00012917};
GN ORFNames=RCJMB04_19g24 {ECO:0000313|EMBL:CAG32177.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:CAG32177.1};
RN [1] {ECO:0000313|EMBL:CAG32177.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CB {ECO:0000313|EMBL:CAG32177.1};
RC TISSUE=Bursa {ECO:0000313|EMBL:CAG32177.1};
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Cleavage of an N-acetyl or N-formyl amino acid from the N-
CC terminus of a polypeptide.; EC=3.4.19.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000721};
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AJ720518; CAG32177.1; -; mRNA.
DR RefSeq; NP_001025756.1; NM_001030585.1.
DR AlphaFoldDB; Q5ZJB6; -.
DR ESTHER; chick-q5zjb6; ACPH_Peptidase_S9.
DR MEROPS; S09.004; -.
DR GeneID; 415926; -.
DR KEGG; gga:415926; -.
DR CTD; 327; -.
DR VEuPathDB; HostDB:geneid_415926; -.
DR PhylomeDB; Q5ZJB6; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR045550; AARE_N.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001375; Peptidase_S9.
DR PANTHER; PTHR42776:SF4; ACYLAMINO-ACID-RELEASING ENZYME; 1.
DR PANTHER; PTHR42776; SERINE PEPTIDASE S9 FAMILY MEMBER; 1.
DR Pfam; PF19283; APEH_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT DOMAIN 13..288
FT /note="Acylamino-acid-releasing enzyme N-terminal"
FT /evidence="ECO:0000259|Pfam:PF19283"
FT DOMAIN 525..733
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 734 AA; 81235 MW; 25CF082CF9234C48 CRC64;
MEPPVLPSAE EAAALYRELS QNPGISTACL GPDVTTQYGG KYCSLYTEWS QRDLVQAKSI
KFCRQYLLFH DGASIVYAGP GGACCEINNE LLSCESPSGA MKAVLLKVAG KEKEKEKEKQ
FLEVWYQNRK VKSIDLTALD KHGSVYDDNQ FGCLAWSHSE THLLYVAEKK RPKAESFFQT
KAPELDCSAD EELECPKKPD APIKGEQFVY HEDWGETLST RSVPVLCVLD IEGSSISVLE
GVPKHVSPGQ AFWSPDDTGV VFVGRWHEPF RLGLRHCNNR RSALFYVDLT GGKCELLSED
TGALWSPRLS PDRCHIAYLE NRVLGPHQQC SRLRMYNWHT KQTRTVLEVV PRQVWGAFPG
IYCSALPRLC WAADSRRLVL DTSQRSQQDV FVVDMQTGST TSLTADAPQG SWSVLTIDRD
LLVAQFSTPS CPATLQVAVL PGVGQEAQIK WICLQNAPPV PGISWGIRTL KPPPEQENPQ
YEGLDFDAIL LRPSEGPTAQ KPPLVVMPHG GPHTVFSAGW MLYPATLCRL GFAVLLVNYR
GSLGFGQDSV NSLPGNVGTQ DVRDVQLCVE RVLQEEQLAA SRVALVGGSH GGFLACHLIG
QFPDTYRACV VRNPVVNIAS MLTITDIPDW CLTEVGVPYE PNALPDPAHL TVMLQKSPMS
YINQVRTPVL LMLGEDDKRV PPAQGLEYYR ALKARGVPTR LLWYPKNNHA LAGIEAEADS
FMNIVLWLLQ HLQG
//
