ID Q5ZME1_CHICK Unreviewed; 349 AA.
AC Q5ZME1;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 143.
DE SubName: Full=Heteroous nuclear ribonucleoprotein A2/B1 {ECO:0000313|Ensembl:ENSGALP00010002516.1};
GN Name=HNRNPA2B1 {ECO:0000313|Ensembl:ENSGALP00010002516.1};
GN ORFNames=RCJMB04_2g17 {ECO:0000313|EMBL:CAG31102.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:CAG31102.1};
RN [1] {ECO:0000313|EMBL:CAG31102.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CB {ECO:0000313|EMBL:CAG31102.1};
RC TISSUE=Bursa {ECO:0000313|EMBL:CAG31102.1};
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
RN [2] {ECO:0000313|Ensembl:ENSGALP00010002516.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010002516.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AJ719443; CAG31102.1; -; mRNA.
DR RefSeq; NP_001026156.1; NM_001030985.1.
DR RefSeq; XP_015136946.1; XM_015281460.1.
DR RefSeq; XP_015136947.1; XM_015281461.1.
DR RefSeq; XP_015136948.1; XM_015281462.1.
DR IntAct; Q5ZME1; 1.
DR PaxDb; 9031-ENSGALP00000017954; -.
DR Ensembl; ENSGALT00010004219.1; ENSGALP00010002516.1; ENSGALG00010001857.1.
DR GeneID; 420627; -.
DR KEGG; gga:420627; -.
DR CTD; 3181; -.
DR VEuPathDB; HostDB:geneid_420627; -.
DR eggNOG; KOG0118; Eukaryota.
DR GeneTree; ENSGT00940000154431; -.
DR HOGENOM; CLU_012062_1_0_1; -.
DR TreeFam; TF351342; -.
DR Proteomes; UP000000539; Chromosome 2.
DR Bgee; ENSGALG00000011036; Expressed in ovary and 12 other cell types or tissues.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0035198; F:miRNA binding; IEA:Ensembl.
DR GO; GO:0140693; F:molecular condensate scaffold activity; IEA:Ensembl.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IEA:Ensembl.
DR GO; GO:1990247; F:N6-methyladenosine-containing RNA reader activity; IEA:Ensembl.
DR GO; GO:0097157; F:pre-mRNA intronic binding; IEA:Ensembl.
DR GO; GO:0043047; F:single-stranded telomeric DNA binding; IEA:Ensembl.
DR GO; GO:1990428; P:miRNA transport; IEA:Ensembl.
DR GO; GO:0006406; P:mRNA export from nucleus; IEA:Ensembl.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:Ensembl.
DR GO; GO:0048025; P:negative regulation of mRNA splicing, via spliceosome; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0031053; P:primary miRNA processing; IEA:Ensembl.
DR CDD; cd12762; RRM1_hnRNPA2B1; 1.
DR CDD; cd12581; RRM2_hnRNPA2B1; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR021662; HnRNPA1/A2_C.
DR InterPro; IPR034486; hnRNPA2B1_RRM1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR48026:SF13; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEINS A2_B1; 1.
DR PANTHER; PTHR48026; HOMOLOGOUS TO DROSOPHILA SQD (SQUID) PROTEIN; 1.
DR Pfam; PF11627; HnRNPA1_LC; 1.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50102; RRM; 2.
PE 1: Evidence at protein level;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q5ZME1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 17..100
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 108..187
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 188..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 302..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 349 AA; 36985 MW; F760411873583A41 CRC64;
MPRGDRESDW REKEQFRKLF IGGLSFETTE ESLRNYYEQW GKLTDCVVMR DPASKRSRGF
GFVTFSSMAE VDAAMAARPH TIDGRVVEPK RAVAREESGK PGAHVTVKKL FVGGIKEDTE
EHHLRDYFEE YGKIDTIEII TDRQSGKKRG FGFVTFDDHD PVDKIVLQKY HTINGHNAEV
RKALSRQEMQ EVQNSRSGRG GNFGFGDARG GGGNFGPGPG SNFRGGADGY GSGRGFGDGY
NGYGGGPGGG NFGGSPGYGG GRGGYGGGGP GYGNQGGGYG GGYDNYGGGN YGSGNYNDFG
NYNQQPSNYG PMKSGNFGGS RNMGGPYGGG NYGPGGSGGS GGYGGRSRY
//
