ID Q5ZTI3_LEGPH Unreviewed; 1453 AA.
AC Q5ZTI3;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 127.
DE SubName: Full=Peptide synthetase, non-ribosomal {ECO:0000313|EMBL:AAU28244.1};
GN OrderedLocusNames=lpg2179 {ECO:0000313|EMBL:AAU28244.1};
OS Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC
OS 33152 / DSM 7513).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=272624 {ECO:0000313|EMBL:AAU28244.1, ECO:0000313|Proteomes:UP000000609};
RN [1] {ECO:0000313|EMBL:AAU28244.1, ECO:0000313|Proteomes:UP000000609}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Philadelphia 1 / ATCC 33152 / DSM 7513
RC {ECO:0000313|Proteomes:UP000000609};
RX PubMed=15448271; DOI=10.1126/science.1099776;
RA Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G.,
RA Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V.,
RA Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S., Georghiou A.,
RA Chou I.C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A.,
RA Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A.,
RA Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A.,
RA Russo J.J.;
RT "The genomic sequence of the accidental pathogen Legionella pneumophila.";
RL Science 305:1966-1968(2004).
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DR EMBL; AE017354; AAU28244.1; -; Genomic_DNA.
DR RefSeq; YP_096191.1; NC_002942.5.
DR STRING; 272624.lpg2179; -.
DR ESTHER; legpa-q5x3a5; Thioesterase.
DR PaxDb; 272624-lpg2179; -.
DR DNASU; 3079010; -.
DR KEGG; lpn:lpg2179; -.
DR PATRIC; fig|272624.6.peg.2288; -.
DR eggNOG; COG0223; Bacteria.
DR eggNOG; COG1020; Bacteria.
DR eggNOG; COG3319; Bacteria.
DR HOGENOM; CLU_003693_0_0_6; -.
DR OrthoDB; 9757559at2; -.
DR Proteomes; UP000000609; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd08700; FMT_C_OzmH_like; 1.
DR CDD; cd08649; FMT_core_NRPS_like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12230; -; 1.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020459; AMP-binding.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR005793; Formyl_trans_C.
DR InterPro; IPR002376; Formyl_transf_N.
DR InterPro; IPR036477; Formyl_transf_N_sf.
DR InterPro; IPR011034; Formyl_transferase-like_C_sf.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR44845:SF6; BETA-ALANINE-ACTIVATING ENZYME; 1.
DR PANTHER; PTHR44845; CARRIER DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF02911; Formyl_trans_C; 1.
DR Pfam; PF00551; Formyl_trans_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR PRINTS; PR00154; AMPBINDING.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR SUPFAM; SSF50486; FMT C-terminal domain-like; 1.
DR SUPFAM; SSF53328; Formyltransferase; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000000609}.
FT DOMAIN 1109..1184
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1453 AA; 165945 MW; 3E389B04F3402ADF CRC64;
MAFINRSSLT AWSTMIKSKT FSCYIIGEAN ITLQCADILL AGGHKLLGII SPSNTIKKWC
TANSIAYLEN IKEFEKNHMD EEFDFLFSIV NSEIIPQKIL RLPRYYAINY HNSPLPKYAG
LYATSWAILN GETQHGISWH IMNEVIDAGD ILKQPTFPIN DLDTAFSLNL KCYEQGIYSF
HELVEELSSH TTTSVKQNLS CRSYYGLKNK PANFGFISWE ESSESIDRLC RALTFGNYTN
QLEVPKIMIN KEIYVVKSYE KLNISSGVKP GTVVNNSNGG LQVATGTTDI LILELTDLEG
RTCSMEELGS LFKMTRYSQL DTIEPAFFEK LTICPAKKPK IEKFWVNEFL KCAQEKNSFL
SPLSQLDKTS CSLHDRKTVT QVPGELLAKL KKLCPEHWQI KNILLTSLLI YLYRLNNYSN
LSIAFINSQL SSNDPDLNKL LSDYVPLTTQ FDSTMTFMDA LTFVSKEQGK LYENSTYTRD
IFIRYPELHN AFNHIDVSIT YITDSKAVAP CVGDKKLNFC IAEDCSWFYV NNKTNYRAHL
ESYAFFENMN EHLLTLLEDI VSNPDKKIFE LSIISKKEKN DLLVVWNNTQ CDYDYEKPIH
QYFEEQVSKT PDEIAAVFEN KSITYVELNR KANQLAHYLR SQGVKQDDLV GISLSRSLEM
VICILGILKS GGAYLPLDPN YPDERISYML MDSKTNLLIT DQEFIKRKPH GFNGKSIEIN
SFLNLKNLSS ENLQAINKPS DLAYIIYTSG TTGKPKGVAI SHRSICNHML WMKKEYAFKN
KDVFLQKTPF SFDASVWEFF MPLLVGGKLV VAPNDAHTSP NQMIRLIREN KVSVLQIVPS
MLKELVSNEE FGLCKSLTHV FCGGEALLSE TINAFFKYNF SDTKLHNLYG PTEVTIDTTA
YTCTAGDAKG DVSRIGKPIM NTKVYVLDAK MQPVPIGIMG ELYISGDGLA RGYLNNPEFT
IQKFLPNPFS NNKNDRLYRT GDLVKWNSNG VLEYHGRCDN QVKIRGYRIE INEIESYLEK
IPSIHQCIVK PEKNQDDSMS LSAYLVLEKN SQISAVDIRA ILKQNIPEYM IPARFYIVDK
FFSTPSGKID RKMLPIPSKR LRSGTNYAPP NNPKEQLLHN IWCSVLKIDN LGIYDDFFEL
GGNSLSAMNI ISHIREQFSL TLSVRTLFDF PTISSLSKAI ENIYHKKTDC IYNQSSGNHI
IPLRTEGEKT PLFLVHPIGG SVFWYKLLGQ YFDKDRPLYG IQDPGLDRNE LIFSNLEEMA
SAYVHSIQAI QPSGPYILGG ASFGCTVAIE MAKQLEEKGE TVISIISLDG WAFYPSLQNN
ELYFQEVMKE QNSRILKKYI ENNVSNSKFL LELQWHRENM LTQYKMPIIK PKFILFKAKK
LTEMFQYNAS LNWWENYTSQ PIELHLTPGD HESMFYEPNI KILATKLNDS LNEQDIKHYQ
FNDTLKDSFI DQL
//
