ID Q5ZTY9_LEGPH Unreviewed; 562 AA.
AC Q5ZTY9;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=Serine metalloprotease {ECO:0000313|EMBL:AAU28088.1};
DE EC=3.4.21.- {ECO:0000313|EMBL:AAU28088.1};
GN OrderedLocusNames=lpg2019 {ECO:0000313|EMBL:AAU28088.1};
OS Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC
OS 33152 / DSM 7513).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=272624 {ECO:0000313|EMBL:AAU28088.1, ECO:0000313|Proteomes:UP000000609};
RN [1] {ECO:0000313|EMBL:AAU28088.1, ECO:0000313|Proteomes:UP000000609}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Philadelphia 1 / ATCC 33152 / DSM 7513
RC {ECO:0000313|Proteomes:UP000000609};
RX PubMed=15448271; DOI=10.1126/science.1099776;
RA Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G.,
RA Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V.,
RA Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S., Georghiou A.,
RA Chou I.C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A.,
RA Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A.,
RA Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A.,
RA Russo J.J.;
RT "The genomic sequence of the accidental pathogen Legionella pneumophila.";
RL Science 305:1966-1968(2004).
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
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DR EMBL; AE017354; AAU28088.1; -; Genomic_DNA.
DR RefSeq; WP_010947735.1; NC_002942.5.
DR RefSeq; YP_096035.1; NC_002942.5.
DR AlphaFoldDB; Q5ZTY9; -.
DR SMR; Q5ZTY9; -.
DR STRING; 272624.lpg2019; -.
DR PaxDb; 272624-lpg2019; -.
DR KEGG; lpn:lpg2019; -.
DR PATRIC; fig|272624.6.peg.2114; -.
DR eggNOG; COG1404; Bacteria.
DR HOGENOM; CLU_475522_0_0_6; -.
DR OrthoDB; 9790784at2; -.
DR Proteomes; UP000000609; Chromosome.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Metalloprotease {ECO:0000313|EMBL:AAU28088.1};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000000609};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..562
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004265278"
FT DOMAIN 165..432
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT ACT_SITE 173
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 214
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 398
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 562 AA; 60477 MW; DE79FE1D8A088F63 CRC64;
MGLKSGILGL SLLSLACGSF AMTETETIRV IIKYKQQPAT IASLKSQVIK SVQIPVKEMK
PMANGAYSLI FDTSNSHAIV KSKEEDVTAK VLERLRKNPN VLYAVKDRIG HFKPLPDPVI
NQELSQLLSH ESQWDEFERP AGIRLESRPG LRDGAWAYTT GKSRKPIVVA VLDTGIALND
SLVNNLVKDN EGNVFGWNFA GNNNDLSDET RSYHGTHVAG TIAGYGDVMN GVGEDLKILT
VKIPAENGMF YESAVVNSIY WAVGGDVPGV PKNIHPAKVL NMSFGVDLEP GKEIDYCDEA
LQEALFFARK KGAVVAVAAG NDNVWEHYNA PAVCNGTIKV ASTGPEGLRS YFSNYGPSIT
LAAPGGDKRY GTSGGILSTV NPGGGYNSSG FDFYQGTSMA SPHVAGVAGL IFAVSNKALK
PEQVEQILYV TTHEFGQSND TNKSCVGKKP CGHGILDADN AVQAALNAYD VLFSAPKMIA
LATHECGENR LKPGKNIIND STATWIQAKS SCETGVSYQK PRIEKAKDGK IYAYYGSVSY
ELDQSAYKEC RVVGYDGVGC YL
//
