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Database: UniProt
Entry: Q608K0
LinkDB: Q608K0
Original site: Q608K0 
ID   DAPD_METCA              Reviewed;         271 AA.
AC   Q608K0;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   14-MAY-2014, entry version 69.
DE   RecName: Full=2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase;
DE            EC=2.3.1.117;
DE   AltName: Full=Tetrahydrodipicolinate N-succinyltransferase;
DE            Short=THDP succinyltransferase;
DE            Short=THP succinyltransferase;
DE            Short=Tetrahydropicolinate succinylase;
GN   Name=dapD; OrderedLocusNames=MCA1490;
OS   Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Methylococcales;
OC   Methylococcaceae; Methylococcus.
OX   NCBI_TaxID=243233;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33009 / NCIMB 11132 / Bath;
RX   PubMed=15383840; DOI=10.1371/journal.pbio.0020303;
RA   Ward N.L., Larsen O., Sakwa J., Bruseth L., Khouri H.M., Durkin A.S.,
RA   Dimitrov G., Jiang L., Scanlan D., Kang K.H., Lewis M.R., Nelson K.E.,
RA   Methe B.A., Wu M., Heidelberg J.F., Paulsen I.T., Fouts D.E.,
RA   Ravel J., Tettelin H., Ren Q., Read T.D., DeBoy R.T., Seshadri R.,
RA   Salzberg S.L., Jensen H.B., Birkeland N.K., Nelson W.C., Dodson R.J.,
RA   Grindhaug S.H., Holt I.E., Eidhammer I., Jonasen I., Vanaken S.,
RA   Utterback T.R., Feldblyum T.V., Fraser C.M., Lillehaug J.R.,
RA   Eisen J.A.;
RT   "Genomic insights into methanotrophy: the complete genome sequence of
RT   Methylococcus capsulatus (Bath).";
RL   PLoS Biol. 2:1616-1628(2004).
CC   -!- CATALYTIC ACTIVITY: Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-
CC       2,6-dicarboxylate + H(2)O = CoA + N-succinyl-L-2-amino-6-
CC       oxoheptanedioate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC       pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate
CC       (succinylase route): step 1/3.
CC   -!- SUBUNIT: Homotrimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
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DR   EMBL; AE017282; AAU92477.1; -; Genomic_DNA.
DR   RefSeq; YP_113947.1; NC_002977.6.
DR   ProteinModelPortal; Q608K0; -.
DR   SMR; Q608K0; 3-270.
DR   STRING; 243233.MCA1490; -.
DR   PRIDE; Q608K0; -.
DR   EnsemblBacteria; AAU92477; AAU92477; MCA1490.
DR   GeneID; 3104489; -.
DR   KEGG; mca:MCA1490; -.
DR   PATRIC; 22606818; VBIMetCap22254_1521.
DR   eggNOG; COG2171; -.
DR   HOGENOM; HOG000003295; -.
DR   KO; K00674; -.
DR   OMA; YIARNTV; -.
DR   OrthoDB; EOG68H8BV; -.
DR   UniPathway; UPA00034; UER00019.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008666; F:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0019877; P:diaminopimelate biosynthetic process; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-HAMAP.
DR   Gene3D; 1.10.166.10; -; 1.
DR   HAMAP; MF_00811; DapD; 1.
DR   InterPro; IPR005664; DapD_Trfase_Hexpep_rpt_fam.
DR   InterPro; IPR001451; Hexapep_transf.
DR   InterPro; IPR018357; Hexapep_transf_CS.
DR   InterPro; IPR023180; THP_succinylTrfase_dom1.
DR   InterPro; IPR011004; Trimer_LpxA-like.
DR   PANTHER; PTHR19136:SF52; PTHR19136:SF52; 1.
DR   Pfam; PF00132; Hexapep; 1.
DR   Pfam; PF14805; THDPS_N_2; 1.
DR   SUPFAM; SSF51161; SSF51161; 1.
DR   TIGRFAMs; TIGR00965; dapD; 1.
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Amino-acid biosynthesis; Complete proteome;
KW   Cytoplasm; Diaminopimelate biosynthesis; Lysine biosynthesis; Repeat;
KW   Transferase.
FT   CHAIN         1    271       2,3,4,5-tetrahydropyridine-2,6-
FT                                dicarboxylate N-succinyltransferase.
FT                                /FTId=PRO_0000196948.
FT   BINDING     103    103       Substrate (By similarity).
FT   BINDING     140    140       Substrate (By similarity).
SQ   SEQUENCE   271 AA;  28841 MW;  2676714A82D9CB1F CRC64;
     MSLENIINEA FENRAQISPG TVGAEVREAV AEALRLLDSG AARVAEKKDG GWVVNQWLKK
     AVLLSFRIND NRVMDGGETR YFDKVEPKFG GFGPEEFRAA GVRVVPPAAV RRGAYIAPGV
     ILMPSYVNIG AYVDSGTMVD TWATVGSCAQ IGKNVHLSGG VGIGGVLEPL QAGPTIIEDN
     CFIGARSEIV EGVIVEEGSV ISMGVYIGQS TKIYNRMTGE ISYGRVPAGS VVVSGNLPAR
     DGSHSLYCAV IIKQVDEKTR GKVGINELLR D
//
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