ID   Q60CZ7_SOLDE            Unreviewed;      1151 AA.
AC   Q60CZ7;
DT   23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2006, sequence version 2.
DT   27-MAR-2024, entry version 77.
DE   SubName: Full=Late blight resistance protein, putative {ECO:0000313|EMBL:AAU93590.2};
GN   ORFNames=SDM1_52t00020 {ECO:0000313|EMBL:AAU93590.2};
OS   Solanum demissum (Wild potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=50514 {ECO:0000313|EMBL:AAU93590.2};
RN   [1] {ECO:0000313|EMBL:AAU93590.2}
RP   NUCLEOTIDE SEQUENCE.
RA   Buell R., Liu J., Childs K., Zaborsky J., Tallon L., Wirtz U., Wei F.,
RA   Kuang H., Zhang P., Marano M., Baker B.;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAU93590.2}
RP   NUCLEOTIDE SEQUENCE.
RA   Childs K.;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC       races carrying the avirulence gene Avr1. Resistance proteins guard the
CC       plant against pathogens that contain an appropriate avirulence protein
CC       via an indirect interaction with this avirulence protein. That triggers
CC       a defense system including the hypersensitive response, which restricts
CC       the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000256|ARBA:ARBA00008894}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC151815; AAU93590.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q60CZ7; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR   CDD; cd14798; RX-CC_like; 1.
DR   Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR021929; R1A-like_N.
DR   InterPro; IPR038005; RX-like_CC.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR   PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF12061; NB-LRR; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Plant defense {ECO:0000256|ARBA:ARBA00022821}.
FT   DOMAIN          49..338
FT                   /note="Late blight resistance protein R1A-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12061"
FT   DOMAIN          499..737
FT                   /note="NB-ARC"
FT                   /evidence="ECO:0000259|Pfam:PF00931"
SQ   SEQUENCE   1151 AA;  132356 MW;  2B11DC5BEA8CFE6F CRC64;
     MDIFLSIQSF TDEPNMLNVT QKVHALFQDS AFDVSKIYQN LNRLTSLLQN KIQVTKMEIR
     ANYSFFPGIS LQLPSLEKSG VDNSKFVMKF INGVVQNLRE LAEIDDFCSR EIQEVLKELK
     LLKSLVGFLS NRWCAEPQSV RTFFGHVLFV AGFAAMVVWL YMPSYDNNRD QDLVPGEMNF
     LLSYLVRMRI KPVIPCIRKM YVDVLQALKW TMQSDLSLNI QNVYVAEIEA GFVETLIHNM
     EEIRSISTLS RIEFLNHQMA TLVEMLKFLR ANLIHLPILG LEFHLQDIDT VIIDVGLLVY
     SLYDCEEQEE VNQRLFIDLP KSIQHINEVI FLVSRKAFQY NLPKVHGLGC VDFLLNNLKE
     FQDRYSDSHY SFVKSQLQVI QKELEGLQPF LKDVAEECYN KHERLQHCAA LLNGKAYEVE
     YIVDASVRKG VPEWCLVRWL FDIIKEVILI KEEVTKIQEK ELFKFDFVLH DTLDTTPAHI
     SSESTNTPRM TDEEVVGFED VMEKLRDQLI RGTKQLDVIS VVGMPGLGKT TVANKLYSDK
     LVVSRFDICA KCCVSQAYSR RSVLLSILRD AIGESPTLTK LSTDVLVDQL RKTLLWKRYL
     ILVDDIWEAS VWDDLRCCFH DSNNGSRIIL TTQHADVAEN AKSVSDPLHL RILNDDESWK
     LLKQKVFGEE SYSVLLSNVG QEIANKCRGL PLSIVLVAGM LTKMEKSEQC WKQVAMNLCT
     NVLSNSKAII EQSYQNLPYH LKPCFLYFGV FLEDKEINIS ILTWLWISEG FIKSRDDKSL
     EDIAEGYLEN LIGRNLVMVA KWGSGGKVKT CRIHDLLLYF CKERAKEKNL LLWMKRDQNV
     NTSSSIYSHK QLVQRRMPIN SQVIDLVKWS SLVGTVHCRE DRNKGSFSIV QFSHIYFRFL
     KVLNLELIVI DSFPTELVYL RYFAARTSQK SITSSTVNLR NLETLIVKPM GGKLILPLTL
     LNMVKLRHLQ IYSKAHFSTL NAAEELLENS KFNNLITLSS PTFCCVRDAE LMLRTPNLRK
     LRCSFVGWGY PSHHCNASKP SGTQAGSSIF LKGRMGRTSD KFHQLKVLKV VDCPCFKKWS
     VSDDAFPCLE HLVLRRCRYL EAIPSRFGDI TSLISIEVKS CKESLVESAM VIRESQVEEM
     QNYDFKVFIH K
//