ID Q60FB5_ONCMY Unreviewed; 504 AA.
AC Q60FB5;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 13-SEP-2023, entry version 95.
DE SubName: Full=NADPH oxidase cytosolic protein p67phox {ECO:0000313|EMBL:BAD60783.1};
DE SubName: Full=Neutrophil cytosolic factor 2 {ECO:0000313|EMBL:AAU04545.1};
GN Name=p67phox {ECO:0000313|EMBL:BAD60783.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:BAD60783.1};
RN [1] {ECO:0000313|EMBL:BAD60783.1}
RP NUCLEOTIDE SEQUENCE.
RA Hoshiko M., Moritomo T., Serada K., Inoue Y., Nakanishi T.;
RT "Molecular cloning and expression of rainbow trout (Oncorhynchus mykiss)
RT NADPH oxidase.";
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAU04545.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19071219; DOI=10.1016/j.fsi.2008.11.011;
RA Boltana S., Donate C., Goetz F.W., MacKenzie S., Balasch J.C.;
RT "Characterization and expression of NADPH oxidase in LPS-, poly(I:C)- and
RT zymosan-stimulated trout (Oncorhynchus mykiss W.) macrophages.";
RL Fish Shellfish Immunol. 26:651-661(2009).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY597049; AAU04545.1; -; mRNA.
DR EMBL; AB192469; BAD60783.1; -; mRNA.
DR RefSeq; NP_001117976.1; NM_001124504.1.
DR AlphaFoldDB; Q60FB5; -.
DR GeneID; 100136240; -.
DR KEGG; omy:100136240; -.
DR OrthoDB; 11738at2759; -.
DR GO; GO:0043020; C:NADPH oxidase complex; IEA:InterPro.
DR GO; GO:0016176; F:superoxide-generating NADPH oxidase activator activity; IEA:InterPro.
DR GO; GO:0006909; P:phagocytosis; IEA:InterPro.
DR GO; GO:0045730; P:respiratory burst; IEA:InterPro.
DR CDD; cd06406; PB1_P67; 1.
DR CDD; cd12046; SH3_p67phox_C; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR034889; NCF2_SH3.
DR InterPro; IPR034885; PB1_P67.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR15175:SF3; NEUTROPHIL CYTOSOL FACTOR 2; 1.
DR PANTHER; PTHR15175; NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF14604; SH3_9; 1.
DR Pfam; PF13181; TPR_8; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 2.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50002; SH3; 2.
PE 2: Evidence at transcript level;
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 241..300
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 442..501
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 303..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..333
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 504 AA; 56836 MW; FDE8FAAEC70FB05C CRC64;
MSFVNTLKQW DEAVACFERG DSAASLGTFL DIQEKNSKIF FNVGCLHLIN KNLDAAEKAF
DGSIGKDGHL AVAFFQRALT FYKKERYEES LADFQHAFRE LRGNQLIDYK PLGLRYKLYA
CEVLHNMALA HAQLGQWEKA KETILTALNL RTEAKLSHID RGLECILKQK VFEPVEVPAK
VVFKPNKNYV AELEKKDYLG KAKVVSSIVF QDDFSGFAPL QPQVEEVPTR PKVPEVLRAL
EEGEPHTVLF EFVPETSDEL AVVPGNIVFV LNSGEDNWAS VIFNERRGLV PYNFLERLEI
TLSSKQDQDG TDKDDIPAPP RPEPLKRPKR KSALAAENQS IGDTETESCR IEESSLCVVK
VHFTYTITMC MVPGLPYTTT LEKISNKLGL PAMAITLSYA HLDSGKIVID EDTRMEDVWS
CVHNGRLTLW CDLKEGMSEQ LQSQNQLMAL HSYESSTPED LEFHQGDTIL LLSKVNEDWF
EGQCNGKIGI FPASFVEEVS MKDK
//
