ID   Q60FH0_HELPX            Unreviewed;       983 AA.
AC   Q60FH0;
DT   23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT   23-NOV-2004, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   SubName: Full=Cag pathogenicity island protein E {ECO:0000313|EMBL:BAD51915.1};
GN   Name=cagE {ECO:0000313|EMBL:BAD51915.1};
OS   Helicobacter pylori (Campylobacter pylori).
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=210 {ECO:0000313|EMBL:BAD51915.1};
RN   [1] {ECO:0000313|EMBL:BAD51915.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=OK118 {ECO:0000313|EMBL:BAD51915.1};
RX   PubMed=16081930; DOI=10.1128/JCM.43.8.3906-3916.2005;
RA   Yamazaki S., Yamakawa A., Okuda T., Ohtani M., Suto H., Ito Y.,
RA   Yamazaki Y., Keida Y., Higashi H., Hatakeyama M., Azuma T.;
RT   "Distinct diversity of vacA, cagA, and cagE genes of Helicobacter pylori
RT   associated with peptic ulcer in Japan.";
RL   J. Clin. Microbiol. 43:3906-3916(2005).
CC   -!- SIMILARITY: Belongs to the TrbE/VirB4 family.
CC       {ECO:0000256|ARBA:ARBA00006512}.
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DR   EMBL; AB191086; BAD51915.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q60FH0; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR   Gene3D; 1.10.8.730; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR   InterPro; IPR004346; CagE_TrbE_VirB.
DR   InterPro; IPR018145; CagE_TrbE_VirB_cntrl_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR043964; P-loop_TraG.
DR   NCBIfam; TIGR00929; VirB4_CagE; 1.
DR   PANTHER; PTHR30121:SF6; TYPE IV SECRETION SYSTEM PROTEIN CAGE; 1.
DR   PANTHER; PTHR30121; UNCHARACTERIZED PROTEIN YJGR-RELATED; 1.
DR   Pfam; PF03135; CagE_TrbE_VirB; 1.
DR   Pfam; PF19044; P-loop_TraG; 1.
DR   SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT   TRANSMEM        60..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        85..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          326..531
FT                   /note="CagE TrbE VirB component of type IV transporter
FT                   system central"
FT                   /evidence="ECO:0000259|Pfam:PF03135"
FT   DOMAIN          579..912
FT                   /note="TraG P-loop"
FT                   /evidence="ECO:0000259|Pfam:PF19044"
SQ   SEQUENCE   983 AA;  111984 MW;  E98AF0E5BE8E1D8C CRC64;
     MFVASKQADE QKKLIIEQEV QKRQFQKIEE LKADMQKGVN PFFKVLFDGG NRLFGFPETF
     IYSSIFILFV TIVLSVILFQ AYEPVLIVAI VIVLVALGFK KDYRLYQRME RAMKFKKPFL
     FKSVKNKAFM SIFSMKPSKE MANDIHLNPN REDRLVSAAN SYLANNYECF LDDGVILTNN
     YSLLGTIKLG GIDFLTTSKK DLIELHASIY SVFRNFVTPE FKFYFHTVKK KIVIDETNRD
     YGLAFSNDFM RAYDEKQKRE SFYDISFFLT IEHDLLDTLN EPVMNKKHFA DNNFEEFQRI
     IRAKLENFKD RIELIEELLS KYHPTRLKEY IKDGVVYSKQ CEFYNFLVGM NEAPFICNRK
     DLYLKEKMHG GVKEVYFANK HGKILNDDLS EKYFSAIEIS EYAPKSQSDL FDKINALDSE
     FIFMHAYSPK NSQVLKDKLA FTSRRIIISG GSKEQGMTLG CLSELVGNGD ITLGSYGNSL
     VLFADSFEKM KQSVKECVSS LNAKGFLANA ATFSMENYFF AKHCSFITLP FIFDVTSNNF
     ADFIAMRAMS FDGNQENNAW GNSVMTLKSE INSPFYLNFH MPTDFGSASA GHTLILGSTG
     SGKTVFMSMT LNAMGQFAYN FPANVSKDRQ KLTMVYMDKD YGAYGNIVAM GGEYVKIELG
     TDTGLNPFAW AACVQKSNAT MEQKQTAISV VKELVKNLAT KSDEKDENGN SISFSLADSN
     TLAAAVTNLI TGDMNLDYPI TQLINAFGKD HNDPNGLVAR LAPFCKSTNG EFQWLFDNKA
     TDRLDFSKTI IGVDGSSFLD NNDVSPFICF YLFARIQEAM DGRRFVLDID EAWKYLGDPK
     VAYFVRDMLK TARKRNAIVR LATQSITDLL ACPIADTIRE QCPTKIFLRN DGGNLSDYQR
     LANVTEKEFE IITKGLDRKI LYKQDGSPSV IASFNLRGIP KEYLKILSTD TVFVKEIDKI
     IQNHSIIDKY QALRQMYQQI KEY
//