ID Q63ZT4_XENLA Unreviewed; 781 AA.
AC Q63ZT4;
DT 25-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 111.
DE RecName: Full=Catenin beta-1 {ECO:0000256|ARBA:ARBA00039590};
DE AltName: Full=Beta-catenin {ECO:0000256|ARBA:ARBA00042006};
GN Name=ctnnb1.L {ECO:0000313|RefSeq:NP_001084045.1,
GN ECO:0000313|Xenbase:XB-GENE-6254184};
GN Synonyms=B-catenin {ECO:0000313|RefSeq:NP_001084045.1}, beta-catenin
GN {ECO:0000313|EMBL:AAH82826.1, ECO:0000313|RefSeq:NP_001084045.1},
GN ctnnb {ECO:0000313|RefSeq:NP_001084045.1}, ctnnb1
GN {ECO:0000313|RefSeq:NP_001084045.1,
GN ECO:0000313|Xenbase:XB-GENE-6254184}, ctnnb1-a
GN {ECO:0000313|RefSeq:NP_001084045.1}, ctnnb1-b
GN {ECO:0000313|RefSeq:NP_001084045.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH82826.1};
RN [1] {ECO:0000313|RefSeq:NP_001084045.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=1962194; DOI=10.1126/science.1962194;
RA McCrea P.D., Turck C.W., Gumbiner B.;
RT "A homolog of the armadillo protein in Drosophila (plakoglobin) associated
RT with E-cadherin.";
RL Science 254:1359-1361(1991).
RN [2] {ECO:0000313|RefSeq:NP_001084045.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [3] {ECO:0000313|RefSeq:NP_001084045.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15163629; DOI=10.1242/dev.01176;
RA Sinner D., Rankin S., Lee M., Zorn A.M.;
RT "Sox17 and beta-catenin cooperate to regulate the transcription of
RT endodermal genes.";
RL Development 131:3069-3080(2004).
RN [4] {ECO:0000313|RefSeq:NP_001084045.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15138495; DOI=10.1371/journal.pbio.0020092;
RA Kuroda H., Wessely O., De Robertis E.M.;
RT "Neural induction in Xenopus: requirement for ectodermal and endomesodermal
RT signals via Chordin, Noggin, beta-Catenin, and Cerberus.";
RL PLoS Biol. 2:623-634(2004).
RN [5] {ECO:0000313|EMBL:AAH82826.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH82826.1}, and Eye
RC {ECO:0000313|EMBL:AAI08765.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|RefSeq:NP_001084045.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15747128; DOI=10.1007/s00427-005-0474-0;
RA Tsuji S., Hashimoto C.;
RT "Choice of either beta-catenin or Groucho/TLE as a co-factor for Xtcf-3
RT determines dorsal-ventral cell fate of diencephalon during Xenopus
RT development.";
RL Dev. Genes Evol. 215:275-284(2005).
RN [7] {ECO:0000313|RefSeq:NP_001084045.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23872074;
RA Schmitz Y., Rateitschak K., Wolkenhauer O.;
RT "Analysing the impact of nucleo-cytoplasmic shuttling of beta-catenin and
RT its antagonists APC, Axin and GSK3 on Wnt/beta-catenin signalling.";
RL Cell. Signal. 25:2210-2221(2013).
RN [8] {ECO:0000313|RefSeq:NP_001084045.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25157132; DOI=10.1073/pnas.1414437111;
RA Komiya Y., Mandrekar N., Sato A., Dawid I.B., Habas R.;
RT "Custos controls beta-catenin to regulate head development during
RT vertebrate embryogenesis.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:13099-13104(2014).
RN [9] {ECO:0000313|RefSeq:NP_001084045.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25901317;
RA Huang Y.L., Anvarian Z., Doderlein G., Acebron S.P., Niehrs C.;
RT "Maternal Wnt/STOP signaling promotes cell division during early Xenopus
RT embryogenesis.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:5732-5737(2015).
RN [10] {ECO:0000313|RefSeq:NP_001084045.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27318088;
RA Park D.S., Yoon G.H., Lee H.S., Choi S.C.;
RT "Capsaicin inhibits the Wnt/beta-catenin signaling pathway by down-
RT regulating PP2A.";
RL Biochem. Biophys. Res. Commun. 478:455-461(2016).
RN [11] {ECO:0000313|RefSeq:NP_001084045.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27335344;
RA Thiebaud P., Garbay B., Auguste P., Senechal C.L., Maciejewska Z.,
RA Fedou S., Gauthereau X., Costaglioli P., Theze N.;
RT "Overexpression of Leap2 impairs Xenopus embryonic development and
RT modulates FGF and activin signals.";
RL Peptides 83:21-28(2016).
RN [12] {ECO:0000313|RefSeq:NP_001084045.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the beta-catenin family.
CC {ECO:0000256|ARBA:ARBA00005462}.
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DR EMBL; BC082826; AAH82826.1; -; mRNA.
DR EMBL; BC108764; AAI08765.1; -; mRNA.
DR RefSeq; NP_001084045.1; NM_001090576.1.
DR STRING; 8355.Q63ZT4; -.
DR PaxDb; 8355-Q63ZT4; -.
DR DNASU; 399274; -.
DR GeneID; 399274; -.
DR KEGG; xla:399274; -.
DR AGR; Xenbase:XB-GENE-6254184; -.
DR CTD; 399274; -.
DR Xenbase; XB-GENE-6254184; ctnnb1.L.
DR OMA; YPKLVYT; -.
DR OrthoDB; 50711at2759; -.
DR Proteomes; UP000186698; Chromosome 6L.
DR Bgee; 399274; Expressed in gastrula and 19 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045296; F:cadherin binding; IEA:InterPro.
DR GO; GO:0009948; P:anterior/posterior axis specification; IGI:BHF-UCL.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR CDD; cd21724; CTNNAbd_CTNNB1; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR013284; Beta-catenin.
DR PANTHER; PTHR45976; ARMADILLO SEGMENT POLARITY PROTEIN; 1.
DR PANTHER; PTHR45976:SF4; CATENIN BETA-1; 1.
DR Pfam; PF00514; Arm; 4.
DR PRINTS; PR01869; BCATNINFAMLY.
DR SMART; SM00185; ARM; 12.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 9.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT REPEAT 151..191
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 193..236
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 235..277
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 277..319
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 319..362
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 400..442
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 442..484
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 489..532
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 594..636
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 34..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 735..781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 781 AA; 85495 MW; 210A29C4B538D635 CRC64;
MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG NPEDEDVDTN
QVLYEWEQGF SQSFTQDQVA DIDGQYAMTR AQRVRAAMFP ETLDEGMQIP STQFDSAHPT
NVQRLAEPSQ MLKHAVVNLI NYQDDAELAT RAIPELTKLL NDEDQVVVNK AAVMVHQLSK
KEASRHAIMR SPQMVSAIVR TMQNTNDVET ARCTAGTLHN LSHHREGLLA IFKSGGIPAL
VKMLGSPVDS VLFYAITTLH NLLLHQEGAK MAVRLAGGLQ KMVALLNKTN VKFLAITTDC
LQILAYGNQE SKLIILASGG PQALVNIMRT YSYEKLLWTT SRVLKVLSVC SSNKPAIVEA
GGMQALGLHL TDSSQRLVQN CLWTLRNLSD AATKQEGMEG LLGTLVQLLG SDDINVVTCA
AGILSNLTCN NYKNKMMVCQ VGGIEALVRT VLRAGDREDI TEPAICALRH LTSRHQEAEM
AQNAVRLHYG LPVVVKLLHP PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL
VRAHQDTQRR TSMGGTQQQF VEGVRMEEIV EGCTGALHIL ARDIHNRIVI RGLNTIPLFV
QLLYSPIENI QRVAAGVLCE LAQDKEAAEA IEAEGATAPL TELLHSRNEG VATYAAAVLF
RMSEDKPQDY KKRLSVELTS SLFRTEPMPW NEAADLGLDI GAQGEPLGYR QDDSSYRSFH
AAGYGQDAMG MDSMMDHDMG GHHPGADYPV DGLPDLSHAQ DLMDGLPPGD SNQLAWFDTD
L
//
