ID Q640J3_XENLA Unreviewed; 315 AA.
AC Q640J3;
DT 25-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE SubName: Full=LOC494659 protein {ECO:0000313|EMBL:AAH82632.1};
DE SubName: Full=Secreted frizzled-related protein 5 S homeolog precursor {ECO:0000313|RefSeq:NP_001087974.1};
GN Name=sfrp5.S {ECO:0000313|RefSeq:NP_001087974.1,
GN ECO:0000313|Xenbase:XB-GENE-864922};
GN Synonyms=frp5 {ECO:0000313|RefSeq:NP_001087974.1}, LOC494659
GN {ECO:0000313|EMBL:AAH82632.1}, sFRP-5
GN {ECO:0000313|RefSeq:NP_001087974.1}, sfrp5
GN {ECO:0000313|RefSeq:NP_001087974.1,
GN ECO:0000313|Xenbase:XB-GENE-864922}, sfrp5-a
GN {ECO:0000313|RefSeq:NP_001087974.1}, sfrp5-b
GN {ECO:0000313|RefSeq:NP_001087974.1}, XsFRP5
GN {ECO:0000313|RefSeq:NP_001087974.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH82632.1};
RN [1] {ECO:0000313|RefSeq:NP_001087974.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH82632.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen {ECO:0000313|EMBL:AAH82632.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001087974.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the secreted frizzled-related protein (sFRP)
CC family. {ECO:0000256|ARBA:ARBA00010054}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR EMBL; BC082632; AAH82632.1; -; mRNA.
DR RefSeq; NP_001087974.1; NM_001094505.1.
DR MEROPS; I93.002; -.
DR DNASU; 494659; -.
DR GeneID; 494659; -.
DR KEGG; xla:494659; -.
DR AGR; Xenbase:XB-GENE-864922; -.
DR CTD; 494659; -.
DR Xenbase; XB-GENE-864922; sfrp5.S.
DR OrthoDB; 4814466at2759; -.
DR Proteomes; UP000186698; Chromosome 7S.
DR Bgee; 494659; Expressed in internal ear and 11 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd07444; CRD_SFRP5; 1.
DR CDD; cd03580; NTR_Sfrp1_like; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR041761; SFRP5_CRD.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF46; SECRETED FRIZZLED-RELATED PROTEIN 5; 1.
DR Pfam; PF01392; Fz; 1.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00063; FRI; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50189; NTR; 1.
PE 2: Evidence at transcript level;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001087974.1};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..315
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001087974.1"
FT /id="PRO_5033206911"
FT DOMAIN 44..161
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 177..299
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 59..105
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 124..148
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 315 AA; 36446 MW; 103E7BF4B957C035 CRC64;
MRFQWNILAW MNSLLLGLVL WSSAEEYDYY SWQSDNFQNG RFYTKQSQCV DIPSDLHLCH
NVGYKKMRLP NLLDHETMPE VKQQASSWVP LLAKQCHRDT QLFLCSLFAP ICLERPIYPC
RSLCEVVRDS CAPVMESYGF PWPEMLNCNK FPLDNDLCIT VQFGSKQVTQ PPVTKICTQC
EIEQKSETMR VQLCASDFVL RMRIKEVKIE NGDRKLIAAQ KKKKVLKAGK LKRKEFRKLV
LYIKNAASCP CPQLDNLSGS FLIMGRKVDN KLILTAIYKW DKKSKDMKYA VNFMYSYPCS
DTISHGTGSH LGSFR
//
