GenomeNet

Database: UniProt
Entry: Q641E3
LinkDB: Q641E3
Original site: Q641E3 
ID   ACBD5_XENLA             Reviewed;         467 AA.
AC   Q641E3;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-SEP-2014, entry version 49.
DE   RecName: Full=Acyl-CoA-binding domain-containing protein 5;
GN   Name=acbd5;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acyl-CoA binding protein which acts as the peroxisome
CC       receptor for pexophagy but is dispensable for aggrephagy and
CC       nonselective autophagy. Binds medium- and long-chain acyl-CoA
CC       esters (By similarity).
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane; Single-pass membrane
CC       protein (By similarity).
CC   -!- SIMILARITY: Belongs to the ATG37 family.
CC   -!- SIMILARITY: Contains 1 ACB (acyl-CoA-binding) domain.
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DR   EMBL; BC082394; AAH82394.1; -; mRNA.
DR   RefSeq; NP_001087866.1; NM_001094397.1.
DR   UniGene; Xl.47761; -.
DR   ProteinModelPortal; Q641E3; -.
DR   GeneID; 447727; -.
DR   KEGG; xla:447727; -.
DR   CTD; 91452; -.
DR   Xenbase; XB-GENE-982916; acbd5.
DR   HOVERGEN; HBG106445; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000062; F:fatty-acyl-CoA binding; IEA:InterPro.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.80.10; -; 1.
DR   InterPro; IPR022408; Acyl-CoA-binding_prot_CS.
DR   InterPro; IPR000582; Acyl-CoA-binding_protein.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
DR   InterPro; IPR016347; M-assoc_diazepam-bd-inh.
DR   Pfam; PF00887; ACBP; 1.
DR   PIRSF; PIRSF002412; MA_DBI; 1.
DR   PRINTS; PR00689; ACOABINDINGP.
DR   SUPFAM; SSF47027; SSF47027; 1.
DR   PROSITE; PS00880; ACB_1; 1.
DR   PROSITE; PS51228; ACB_2; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Coiled coil; Lipid-binding; Membrane; Peroxisome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN         1    467       Acyl-CoA-binding domain-containing
FT                                protein 5.
FT                                /FTId=PRO_0000287383.
FT   TRANSMEM    439    459       Helical; (Potential).
FT   DOMAIN        8     97       ACB.
FT   REGION       19     28       Acyl-CoA binding (By similarity).
FT   REGION       39     43       Acyl-CoA binding (By similarity).
FT   COILED      382    411       Potential.
FT   COMPBIAS    155    199       Glu-rich.
FT   BINDING      65     65       Acyl-CoA (By similarity).
FT   BINDING      84     84       Acyl-CoA (By similarity).
SQ   SEQUENCE   467 AA;  51375 MW;  B3B3D73A461C2500 CRC64;
     MADTKPLHQT RFEAAVSVIQ SLPKNGSFQP SNEMMLKFYS FYKQATLGPC NTARPGFWDP
     VGRYKWDAWN SLGDMSKEDA MIAYVDEMKK IIETMPVTDK VEELLQVIGP FYEIVEDKKH
     GRGSGVTSEL GSVLTSTPNG KAVNGKAESS DSGAESDEEQ AAAKEFKKED EEDEEDETEH
     SEEEEKEVEQ QPGHETSAES IVLNGLTKNS RVLITEEPTP LPTKCLSEPG DNVAIPEGEP
     DIQSAVINDS EADREEDCTE DMAAVQHLTS DSDSEIFCDS MEQFGQDEAD HSLLLQDAML
     NGDITENSAG GELKDGGEDG KQPGHGAQGK TWNGKSEHFS SRRERSLRMQ PGGEGSRSGQ
     IGSSGDGDGW GSDRGPIGNL NEQIAVVLMR LQEDMQNVLQ RLHSLEVQTA SQAQSLLRES
     NTQSVEKKPS GWPFGISPGT LALAVVWPFV VHWLMHVFLQ KRRRKQT
//
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