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Database: UniProt
Entry: Q64346
LinkDB: Q64346
Original site: Q64346 
ID   DUS6_RAT                Reviewed;         381 AA.
AC   Q64346;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   26-NOV-2014, entry version 110.
DE   RecName: Full=Dual specificity protein phosphatase 6;
DE            EC=3.1.3.16;
DE            EC=3.1.3.48;
DE   AltName: Full=Mitogen-activated protein kinase phosphatase 3;
DE            Short=MAP kinase phosphatase 3;
DE            Short=MKP-3;
GN   Name=Dusp6; Synonyms=Mkp3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Neuron;
RX   PubMed=8626780; DOI=10.1074/jbc.271.8.4319;
RA   Muda M., Boschert U., Dickinson R., Martinou J.-C., Martinou I.,
RA   Camps M., Schlegel W., Arkinstall S.;
RT   "MKP-3, a novel cytosolic protein-tyrosine phosphatase that
RT   exemplifies a new class of mitogen-activated protein kinase
RT   phosphatase.";
RL   J. Biol. Chem. 271:4319-4326(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8631996; DOI=10.1074/jbc.271.7.3795;
RA   Mourey R.J., Vega Q.C., Campbell J.S., Wenderoth M.P., Hauschka S.D.,
RA   Krebs E.G., Dixon J.E.;
RT   "A novel cytoplasmic dual specificity protein tyrosine phosphatase
RT   implicated in muscle and neuronal differentiation.";
RL   J. Biol. Chem. 271:3795-3802(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Inactivates MAP kinases. Has a specificity for the ERK
CC       family. Implicated in muscle and neuronal differentiation.
CC   -!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein
CC       tyrosine + phosphate.
CC   -!- CATALYTIC ACTIVITY: [a protein]-serine/threonine phosphate + H(2)O
CC       = [a protein]-serine/threonine + phosphate.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC       Non-receptor class dual specificity subfamily. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 rhodanese domain. {ECO:0000255|PROSITE-
CC       ProRule:PRU00173}.
CC   -!- SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.
CC       {ECO:0000305}.
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DR   EMBL; X94185; CAA63895.1; -; mRNA.
DR   EMBL; U42627; AAB06202.1; -; mRNA.
DR   EMBL; BC087003; AAH87003.1; -; mRNA.
DR   RefSeq; NP_446335.1; NM_053883.2.
DR   UniGene; Rn.4313; -.
DR   PDB; 2FYS; X-ray; 2.50 A; C/D=60-76.
DR   PDBsum; 2FYS; -.
DR   ProteinModelPortal; Q64346; -.
DR   SMR; Q64346; 1-154, 205-347.
DR   STRING; 10116.ENSRNOP00000032969; -.
DR   BindingDB; Q64346; -.
DR   ChEMBL; CHEMBL5511; -.
DR   Ensembl; ENSRNOT00000037844; ENSRNOP00000032969; ENSRNOG00000023896.
DR   GeneID; 116663; -.
DR   KEGG; rno:116663; -.
DR   UCSC; RGD:70978; rat.
DR   CTD; 1848; -.
DR   RGD; 70978; Dusp6.
DR   eggNOG; COG2453; -.
DR   GeneTree; ENSGT00760000118902; -.
DR   HOGENOM; HOG000294079; -.
DR   HOVERGEN; HBG007347; -.
DR   InParanoid; Q64346; -.
DR   KO; K04459; -.
DR   OMA; SEWNENT; -.
DR   OrthoDB; EOG793B7W; -.
DR   PhylomeDB; Q64346; -.
DR   TreeFam; TF105122; -.
DR   Reactome; REACT_253470; ERKs are inactivated.
DR   EvolutionaryTrace; Q64346; -.
DR   NextBio; 619455; -.
DR   PRO; PR:Q64346; -.
DR   Genevestigator; Q64346; -.
DR   GO; GO:0005737; C:cytoplasm; IDA:RGD.
DR   GO; GO:0005829; C:cytosol; IDA:RGD.
DR   GO; GO:0017017; F:MAP kinase tyrosine/serine/threonine phosphatase activity; IEA:Ensembl.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IDA:RGD.
DR   GO; GO:0030154; P:cell differentiation; IEP:RGD.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; IBA:RefGenome.
DR   GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IDA:RGD.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IBA:RefGenome.
DR   GO; GO:0010942; P:positive regulation of cell death; IMP:RGD.
DR   GO; GO:0006470; P:protein dephosphorylation; IBA:RefGenome.
DR   GO; GO:0042663; P:regulation of endodermal cell fate specification; IBA:RefGenome.
DR   GO; GO:0040036; P:regulation of fibroblast growth factor receptor signaling pathway; IBA:RefGenome.
DR   GO; GO:0060420; P:regulation of heart growth; IBA:RefGenome.
DR   GO; GO:0042493; P:response to drug; IEP:RGD.
DR   GO; GO:0070848; P:response to growth factor; IEP:RGD.
DR   GO; GO:0051409; P:response to nitrosative stress; IEA:Ensembl.
DR   GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
DR   GO; GO:0010033; P:response to organic substance; IEP:RGD.
DR   Gene3D; 3.40.250.10; -; 1.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR   InterPro; IPR020422; Dual-sp_phosphatase_subgr_cat.
DR   InterPro; IPR024950; DUSP.
DR   InterPro; IPR008343; MKP.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR001763; Rhodanese-like_dom.
DR   InterPro; IPR000387; Tyr/Dual-sp_Pase.
DR   PANTHER; PTHR10159; PTHR10159; 1.
DR   Pfam; PF00782; DSPc; 1.
DR   Pfam; PF00581; Rhodanese; 1.
DR   PIRSF; PIRSF000939; MAPK_Ptase; 1.
DR   PRINTS; PR01764; MAPKPHPHTASE.
DR   SMART; SM00195; DSPc; 1.
DR   SMART; SM00450; RHOD; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   SUPFAM; SSF52821; SSF52821; 1.
DR   PROSITE; PS50206; RHODANESE_3; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Cytoplasm; Hydrolase;
KW   Protein phosphatase; Reference proteome.
FT   CHAIN         1    381       Dual specificity protein phosphatase 6.
FT                                /FTId=PRO_0000094806.
FT   DOMAIN       30    148       Rhodanese. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00173}.
FT   DOMAIN      206    381       Tyrosine-protein phosphatase.
FT   ACT_SITE    293    293       Phosphocysteine intermediate.
FT                                {ECO:0000250}.
SQ   SEQUENCE   381 AA;  42319 MW;  C511E00CB68F2888 CRC64;
     MIDTLRPVPF ASEMAISKTV AWLNEQLELG NEQLLLMDCR PQELYESSHI ESAINVAIPG
     IMLRRLQKGN LPVRALFTRC EDRDRFTRRC GTDTVVLYDE NSSDWNENTG GESVLGLLLK
     KLKDEGCRAF YLEGGFSKFQ AEFALHCETN LDGSCSSSSP PLPVLGLGGL RISSDSSSDI
     ESDLDRDPNS ATDSDGSPLS NSQPSFPVEI LPFLYLGCAK DSTNLDVLEE FGIKYILNVT
     PNLPNLFENA GEFKYKQIPI SDHWSQNLSQ FFPEAISFID EARGKNCGVL VHCLAGISRS
     VTVTVAYLMQ KLNLSMNDAY DIVKMKKSNI SPNFNFMGQL LDFERTLGLS SPCDNRVPAQ
     QLYFTAPSNQ NVYQVDSLQS T
//
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