ID Q64HK9_CANDU Unreviewed; 977 AA.
AC Q64HK9;
DT 25-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
OS Candida dubliniensis (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=42374 {ECO:0000313|EMBL:AAU13915.1};
RN [1] {ECO:0000313|EMBL:AAU13915.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=D1558 {ECO:0000313|EMBL:AAU13915.1};
RX PubMed=15302834; DOI=10.1128/EC.3.4.1015-1027.2004;
RA Pujol C., Daniels K.J., Lockhart S.R., Srikantha T., Radke J.B., Geiger J.,
RA Soll D.R.;
RT "The closely related species Candida albicans and Candida dubliniensis can
RT mate.";
RL Eukaryot. Cell 3:1015-1027(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a
CC 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP +
CC H(+); Xref=Rhea:RHEA:19877, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57880, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216;
CC EC=2.7.1.67; Evidence={ECO:0000256|ARBA:ARBA00001686};
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR EMBL; AY622606; AAU13915.1; -; Genomic_DNA.
DR VEuPathDB; FungiDB:CD36_51560; -.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05168; PI4Kc_III_beta; 1.
DR Gene3D; 6.10.140.1260; -; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR021601; Phosphatidylino_kinase_fungi.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR049160; PI4KB-PIK1_PIK.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF22; PHOSPHATIDYLINOSITOL 4-KINASE BETA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF21245; PI4KB-PIK1_PIK; 1.
DR Pfam; PF11522; Pik1; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..125
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 679..960
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 977 AA; 110360 MW; 98EC3128B0F668DF CRC64;
MSENTPEAPS KQLLERIQSS SFSLFNCIYE LKNHNDSIGI QHELVKKLYS FPYEDLQFFI
PQFVQLLVTY DSNSMALEEF IITSSCRYPH FSLIVFWNLQ AYIFELKNEP ESRSFQAARN
LVTKIQNIMF NTELSVVKAP EFRENLFPAL VLCGAVASSA LLPSFKNYCL PMIKAQGKQQ
KSLVFKLANF QKSLTKNLTL KNQRMSADIP KESHSDDETV VSSSIKPSLS RSASVPRRST
KKASLSFSSD ESEAYTTDDD DNKTSIELEK EFYKMDLNGS LKGGSTKFLE TEENLHVNTA
IKSKKRLSTL TSKVMASSWD SMDGYNVNSQ SLPDLSKADS RDLIPFLSST ESETSLLYNN
NAIANDLQKX TLQQPKFMPG FDNDYLTKIL QVNYAKNETQ FIMALQNISI RLSQVPKEAR
LSALRAELSI INDTLLPSEI DIPQLLPVTS NRNKKYHKIL KLNVNEASVL NSAERVPFLL
FIEYLSDEID FNPTTEYNQR IIARKNIVGA TNTSVKKMNS FSEVPDGNFS KENNLESHIT
ETVTSAICNE STEEADLSEM PIARRTAVSS DSFSPEMLVT PTVTEQSKLS GFPSLNSKEV
STKVLADQMR IAAVMLQQLD SSGKANSEQS FLIKNRIVES MIALQDQFDS FDFEKLSQLQ
SDQPSAGERK LENDFKLGED WNTKKQRIKK SSAYGHLKNW DLCSVIAKNG DDLPQEAFAC
QLISMISNIW KKNQVPVWTK RMKILITSAN TGLVETITNA MSIHSIKKSF TEHSIKSGEN
DKGKIFTLLD YFHSVFGSEN SVSFRTAQQN FAKSLAAYSI ICYVLQIKDR HNGNIMVDRD
GHIIHIDFGF LLSNSPGSVG FEAAPFKLTV EYVELLGGVD SEIYSQFVHL CKQCFKSLRD
NSEEIIEIVE LMQRDSTLPC FNNGENTSVL LRQRLQLQLN DEDTDQFVEN FLIGKSLGSM
YTRLYDQFQM ITQGIYS
//
