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Database: UniProt
Entry: Q65C71_SACBA
LinkDB: Q65C71_SACBA
Original site: Q65C71_SACBA 
ID   Q65C71_SACBA            Unreviewed;       486 AA.
AC   Q65C71;
DT   25-OCT-2004, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2004, sequence version 1.
DT   24-JAN-2024, entry version 70.
DE   SubName: Full=Homoserine O-acetyltransferase {ECO:0000313|EMBL:CAF29079.1};
DE   SubName: Full=Homoserine o-acetyle transferase {ECO:0000313|EMBL:CBY89763.1};
GN   Name=MET2 {ECO:0000313|EMBL:CAF29079.1};
GN   Synonyms=met2 {ECO:0000313|EMBL:CBY89763.1};
OS   Saccharomyces bayanus (Yeast) (Saccharomyces uvarum x Saccharomyces
OS   eubayanus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4931 {ECO:0000313|EMBL:CAF29079.1};
RN   [1] {ECO:0000313|EMBL:CAF29079.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CLIB 181 {ECO:0000313|EMBL:CAF29079.1};
RX   PubMed=15691752; DOI=10.1016/j.femsyr.2004.12.004;
RA   Nguyen H.V., Gaillardin C.;
RT   "Evolutionary relationships between the former species Saccharomyces uvarum
RT   and the hybrids Saccharomyces bayanus and Saccharomyces pastorianus;
RT   reinstatement of Saccharomyces uvarum (Beijerinck) as a distinct species.";
RL   FEMS Yeast Res. 5:471-483(2005).
RN   [2] {ECO:0000313|EMBL:CBY89763.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CBS 2946 {ECO:0000313|EMBL:CBY89764.1}, and CBS 424
RC   {ECO:0000313|EMBL:CBY89763.1};
RA   Nguyen H.V.;
RL   Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:CBY89763.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CBS 2946 {ECO:0000313|EMBL:CBY89764.1}, and CBS 424
RC   {ECO:0000313|EMBL:CBY89763.1};
RA   Nguyen V.H., Legras J.L., Neuveglise C., Gaillardin C.;
RT   "Deciphering the hybridisation history leading to the lager lineage based
RT   on the mosaic genomes of Saccharomyces bayanus strains NBRC 1948and CBS
RT   380^T.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. MetX family.
CC       {ECO:0000256|ARBA:ARBA00006886}.
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DR   EMBL; AJ627635; CAF29079.1; -; Genomic_DNA.
DR   EMBL; FR774000; CBY89763.1; -; Genomic_DNA.
DR   EMBL; FR774001; CBY89764.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q65C71; -.
DR   ESTHER; yeast-met2; Homoserine_transacetylase.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   HAMAP; MF_00296; MetX_acyltransf; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR008220; HAT_MetX-like.
DR   NCBIfam; TIGR01392; homoserO_Ac_trn; 1.
DR   PANTHER; PTHR32268; HOMOSERINE O-ACETYLTRANSFERASE; 1.
DR   PANTHER; PTHR32268:SF11; HOMOSERINE O-ACETYLTRANSFERASE; 1.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   PIRSF; PIRSF000443; Homoser_Ac_trans; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   3: Inferred from homology;
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAF29079.1}.
FT   DOMAIN          66..436
FT                   /note="AB hydrolase-1"
FT                   /evidence="ECO:0000259|Pfam:PF00561"
FT   REGION          248..274
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        162
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000443-1"
FT   ACT_SITE        401
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000443-1"
FT   ACT_SITE        430
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000443-1"
SQ   SEQUENCE   486 AA;  53819 MW;  B7198D5FC8AABDC5 CRC64;
     MSHTLKSKTL QELDIEDIKE TNPLLKLVQG QRIVQIPELV LESGVVLSNF PIAYKTWGTL
     NEACDNVLVI CHALTGSADV ADWWGPLLGN DLAFDPSRFF IICLNSMGSP YGSFSPLTIN
     EQTGTRYGPE FPLCTVRDDV RAHRIVLDSL GVKSIACVIG GSMGGMLSLE WAAMYGNEYV
     KNMVALATSA RHSAWCISWS EAQRQSIYSD PNYLDGYYPV EEQPVAGLSA ARMSALLTYR
     TRNSFENKFS RRSPSIAQQQ KAQKAEARKP STISEHSLQI HNDGYKSKAN GAIVGISGQK
     RQSVVSTTSS SDSLTSQSSM TSVSSITGEV KDIKPAQTYF SAQSYLRYQG TKFINRFDAN
     CYIAITRKLD THDLARDRVE DITKVLSAIE QPSLIIGIQS DGLFTYSEQE FLAEYIPKSQ
     LEKIESPEGH DAFLLEFKRI NKLIVDFLKT NCKNITDAKP STWGGDVGND ETKTSVFGEA
     EEVTNW
//
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