ID Q666F1_YERPS Unreviewed; 436 AA.
AC Q666F1;
DT 11-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE SubName: Full=HlyD family drug efflux protein {ECO:0000313|EMBL:CAH22545.1};
DE Flags: Precursor;
GN OrderedLocusNames=YPTB3307 {ECO:0000313|EMBL:CAH22545.1};
OS Yersinia pseudotuberculosis serotype I (strain IP32953).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=273123 {ECO:0000313|EMBL:CAH22545.1, ECO:0000313|Proteomes:UP000001011};
RN [1] {ECO:0000313|EMBL:CAH22545.1, ECO:0000313|Proteomes:UP000001011}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IP32953 {ECO:0000313|Proteomes:UP000001011};
RX PubMed=15358858; DOI=10.1073/pnas.0404012101;
RA Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O.,
RA Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L.,
RA Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C.,
RA Simonet M., Chenal-Francisque V., Souza B., Dacheux D., Elliott J.M.,
RA Derbise A., Hauser L.J., Garcia E.;
RT "Insights into the evolution of Yersinia pestis through whole-genome
RT comparison with Yersinia pseudotuberculosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX936398; CAH22545.1; -; Genomic_DNA.
DR RefSeq; WP_011193037.1; NZ_CP009712.1.
DR AlphaFoldDB; Q666F1; -.
DR GeneID; 66844268; -.
DR KEGG; ypo:BZ17_3301; -.
DR KEGG; yps:YPTB3307; -.
DR PATRIC; fig|273123.14.peg.3460; -.
DR Proteomes; UP000001011; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0009636; P:response to toxic substance; IEA:UniProt.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30158; ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER; 1.
DR PANTHER; PTHR30158:SF3; MULTIDRUG EFFLUX PUMP SUBUNIT ACRA-RELATED; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 92..255
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT COILED 138..196
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 436 AA; 47143 MW; C28087ED3B792A93 CRC64;
MFTLNWVRST PIFYVPRTLR SRLILRSPLI LRSPRMGPLR AKQHRHSLLS HALFLLILGA
GSVSAATAPL PAVTVAVVAS ITPDNAVQYL GRIEAIQAVD VTTRTEGFIA RRLFTEGKMV
KQGELLYEID PALHQASVAQ AQAQLDSATA SANHAQVNLT RLQRLGNNRS VSQAEVDEAQ
AQRDISRAAV AQAQANLQIQ QLQLSFTQIH APISGQMGHS RFNVGSLINP ASGTLVNIVQ
LDPIRVAIAV NERDYITATY QRAVAREKNI ENPLLLLGTF TPRIQLANGK QYPESGVFES
VDNQIDKQTG TVIIRTRFAN PRHLLLPGGV VNVSLAADDA KPVTVIPIAA LQQNKQGHFV
LVVTDKAVVE VRPVTLGEQF EQQYAVTDGV KVGEKVIVAG LQHVRPGMAV NASTVNDGTV
NDGTVNDRVA APLTAN
//
