ID Q66IY7_XENLA Unreviewed; 436 AA.
AC Q66IY7;
DT 11-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE RecName: Full=vesicle-fusing ATPase {ECO:0000256|ARBA:ARBA00012674};
DE EC=3.6.4.6 {ECO:0000256|ARBA:ARBA00012674};
GN Name=vps4a.L {ECO:0000313|RefSeq:NP_001087722.1,
GN ECO:0000313|Xenbase:XB-GENE-970551};
GN Synonyms=MGC84050 {ECO:0000313|EMBL:AAH81138.1}, vps4a
GN {ECO:0000313|RefSeq:NP_001087722.1,
GN ECO:0000313|Xenbase:XB-GENE-970551}, vsp4
GN {ECO:0000313|RefSeq:NP_001087722.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH81138.1};
RN [1] {ECO:0000313|RefSeq:NP_001087722.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH81138.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye {ECO:0000313|EMBL:AAH81138.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001087722.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004633}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004633}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the AAA ATPase family.
CC {ECO:0000256|ARBA:ARBA00006914, ECO:0000256|RuleBase:RU003651}.
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DR EMBL; BC081138; AAH81138.1; -; mRNA.
DR RefSeq; NP_001087722.1; NM_001094253.1.
DR STRING; 8355.Q66IY7; -.
DR PaxDb; 8355-Q66IY7; -.
DR DNASU; 447546; -.
DR GeneID; 447546; -.
DR KEGG; xla:447546; -.
DR AGR; Xenbase:XB-GENE-970551; -.
DR CTD; 447546; -.
DR Xenbase; XB-GENE-970551; vps4a.L.
DR OMA; IEWTNEF; -.
DR OrthoDB; 276256at2759; -.
DR Proteomes; UP000186698; Chromosome 4L.
DR Bgee; 447546; Expressed in muscle tissue and 20 other cell types or tissues.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd02678; MIT_VPS4; 1.
DR CDD; cd19521; RecA-like_VPS4; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR007330; MIT_dom.
DR InterPro; IPR036181; MIT_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015415; Spast_Vps4_C.
DR InterPro; IPR045253; VPS4_MIT.
DR PANTHER; PTHR23074; AAA DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR23074:SF177; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF04212; MIT; 1.
DR Pfam; PF09336; Vps4_C; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00745; MIT; 1.
DR SUPFAM; SSF116846; MIT domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00674; AAA; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003651};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003651};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT DOMAIN 2..80
FT /note="MIT"
FT /evidence="ECO:0000259|SMART:SM00745"
FT DOMAIN 158..294
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 75..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 436 AA; 48973 MW; 88B601BF9C24281C CRC64;
MTTSTLQKAI DLVTKATEED KNKNYEEALR LYQHAVEYFL HAIKYEAHSD KAKESIRAKC
MQYLDRAEKL KDYLKTKDKQ NKKPVKESQN EKGSDSDSEG ENPEKKKLQE QLMGAIVMEK
PNVRWNDVAG LEGAKEALKE AVILPIKFPH LFTGKRTPWR GILLFGPPGT GKSYLAKAVA
TEANNSTFFS VSSSDLMSKW LGESEKLVKN LFELARQHKP SIIFIDEVDS LCGSRNENES
EAARRIKTEF LVQMQGVGNN NDGILVLGAT NIPWVLDSAI RRRFEKRIYI PLPEEAARAQ
MFRLHLGNTP RNLSEENVRE LAKKTDGYSG ADISIIVRDA LMQPVRKVQS ATHFKKVRGP
SRTNPGIIVD DLLTPCSPGD PGAVEMTWME VSSDKLQEPV VCMSDMLRSL ATTRPTVNAD
DLLKVKKFTD DFGQEG
//
