UniProt: Q66JC1

Database: UniProt
Entry: Q66JC1_XENTR

LinkDB:  Q66JC1_XENTR 
Original site:  Q66JC1_XENTR

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Ontology (4)   
   GO (4)   
Gene (6)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
   XENBASE (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (3)   
   EMBL (3)   
Protein domain (5)   
   InterPro (3)   
   Pfam (1)   
   PROSITE (1)   
Literature (2)   
   PubMed (2)   
All databases (21)   

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ID   Q66JC1_XENTR            Unreviewed;       313 AA.
AC   Q66JC1; F6XA30;
DT   11-OCT-2004, integrated into UniProtKB/TrEMBL.
DT   11-OCT-2004, sequence version 1.
DT   27-MAR-2024, entry version 136.
DE   SubName: Full=MGC79800 protein {ECO:0000313|EMBL:AAH80980.1};
DE   SubName: Full=Novel protein containing three mitochondrial carrier protein domains {ECO:0000313|EMBL:CAJ82399.1};
DE   SubName: Full=Solute carrier family 25 member 44 {ECO:0000313|Ensembl:ENSXETP00000005561, ECO:0000313|RefSeq:NP_001008081.1};
GN   Name=slc25a44 {ECO:0000313|Ensembl:ENSXETP00000005561,
GN   ECO:0000313|RefSeq:NP_001008081.1,
GN   ECO:0000313|Xenbase:XB-GENE-1009006};
GN   Synonyms=MGC79800 {ECO:0000313|EMBL:AAH80980.1};
GN   ORFNames=TNeu057l06.1-001 {ECO:0000313|EMBL:CAJ82399.1},
GN   XENTR_v90030691mg {ECO:0000313|EMBL:OCA15051.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|EMBL:AAH80980.1};
RN   [1] {ECO:0000313|RefSeq:NP_001008081.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12454917; DOI=10.1002/dvdy.10174;
RA   Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA   Richardson P.;
RT   "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT   initiative.";
RL   Dev. Dyn. 225:384-391(2002).
RN   [2] {ECO:0000313|EMBL:AAH80980.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000313|EMBL:AAH80980.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:CAJ82399.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Amaya E., Ashurst J.L., Bonfield J.K., Croning M.D.R., Chen C-K.,
RA   Davies R.M., Francis M.D., Garrett N., Gilchrist M.J., Grafham D.V.,
RA   McLaren S.R., Papalopulu N., Rogers J., Smith J.C., Taylor R.G., Voigt J.,
RA   Zorn A.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:OCA15051.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Nigerian {ECO:0000313|EMBL:OCA15051.1};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Ottilar R., Schmutz J., Salamov A., Cheng J.F., Lucas S., Pitluck S.,
RA   Gundlach H., Guo Y., Haberer G., Nasrallah J., Mayer K.F.X.,
RA   van de Peer Y., Weigel D., Grigoriev I.V.;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:OCA15051.1, ECO:0000313|Ensembl:ENSXETP00000005561}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|EMBL:OCA15051.1,
RC   ECO:0000313|Ensembl:ENSXETP00000005561};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [6] {ECO:0000313|Ensembl:ENSXETP00000005561}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
RN   [7] {ECO:0000313|EMBL:OCA15051.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Nigerian {ECO:0000313|EMBL:OCA15051.1};
RA   Sessions A., Jenkins J., Mitros T., Lyons J.T., Dichmann D.S., Robert J.,
RA   Harland R.M., Rokhsar D.S.;
RT   "WGS assembly of Xenopus tropicalis.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|RefSeq:NP_001008081.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR   EMBL; BC080980; AAH80980.1; -; mRNA.
DR   EMBL; CR855404; CAJ82399.1; -; mRNA.
DR   EMBL; KV460998; OCA15051.1; -; Genomic_DNA.
DR   RefSeq; NP_001008081.1; NM_001008080.2.
DR   DNASU; 493443; -.
DR   Ensembl; ENSXETT00000005561; ENSXETP00000005561; ENSXETG00000002608.
DR   GeneID; 493443; -.
DR   KEGG; xtr:493443; -.
DR   AGR; Xenbase:XB-GENE-1009006; -.
DR   CTD; 9673; -.
DR   Xenbase; XB-GENE-1009006; slc25a44.
DR   eggNOG; KOG0765; Eukaryota.
DR   HOGENOM; CLU_015166_3_3_1; -.
DR   OMA; ELWHEEK; -.
DR   OrthoDB; 609391at2759; -.
DR   TreeFam; TF354268; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Bgee; ENSXETG00000002608; Expressed in gastrula and 12 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IEA:InterPro.
DR   GO; GO:0015658; F:branched-chain amino acid transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0009083; P:branched-chain amino acid catabolic process; IEA:InterPro.
DR   Gene3D; 1.50.40.10; Mitochondrial carrier domain; 2.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   InterPro; IPR042164; SLC25A44.
DR   PANTHER; PTHR46314; SOLUTE CARRIER FAMILY 25 MEMBER 44; 1.
DR   PANTHER; PTHR46314:SF2; SOLUTE CARRIER FAMILY 25 MEMBER 44; 1.
DR   Pfam; PF00153; Mito_carr; 3.
DR   SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU00282}; Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU00282}; Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU000488}.
FT   TRANSMEM        20..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REPEAT          18..100
FT                   /note="Solcar"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT   REPEAT          107..209
FT                   /note="Solcar"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT   REPEAT          219..301
FT                   /note="Solcar"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ   SEQUENCE   313 AA;  35244 MW;  DC551B3EF09F6A87 CRC64;
     MEDKRNIQII EWEHLDKKKF YVFGVCMTMI IRVSVYPFTL IRTRLQVQKG KSLYNGTFDA
     FVKILRTEGA AGFYRGFLVN TFTLISGQCY VTTYELTRKY VSKYSSSNTV KSLVAGGSAS
     LVAQSITVPI DVVSQHLMMQ RKGESMGRFR VHATDGKQPV MFGQTKDIIL QIFRADGFRG
     FYRGYVASLL TYIPNSAVWW PFYHLYAEQL SRLSPNDCPH LLLQAIAGPL AAATASTITN
     PMDVIRARVQ VEGKSSIINT FRQLMAEEGP WGLTKGLSAR IISSTPSTIV IVVGYETLKK
     LSLRPELVDS RHW
//

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