ID Q66JJ1_XENTR Unreviewed; 383 AA.
AC Q66JJ1; F6XDB6;
DT 11-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE SubName: Full=E3 ubiquitin-protein ligase RNF13 isoform X1 {ECO:0000313|RefSeq:XP_012818369.1};
DE SubName: Full=E3 ubiquitin-protein ligase RNF13 precursor {ECO:0000313|RefSeq:NP_001008015.1};
DE EC=2.3.2.27 {ECO:0000313|RefSeq:NP_001008015.1};
DE SubName: Full=Ring finger protein 13 {ECO:0000313|EMBL:AAH80893.1, ECO:0000313|Ensembl:ENSXETP00000043383};
GN Name=rnf13 {ECO:0000313|EMBL:AAH80893.1,
GN ECO:0000313|Ensembl:ENSXETP00000043383,
GN ECO:0000313|RefSeq:NP_001008015.1, ECO:0000313|RefSeq:XP_012818369.1,
GN ECO:0000313|Xenbase:XB-GENE-954771};
GN Synonyms=rzf {ECO:0000313|RefSeq:NP_001008015.1,
GN ECO:0000313|RefSeq:XP_012818369.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAH80893.1};
RN [1] {ECO:0000313|RefSeq:NP_001008015.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH80893.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH80893.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSXETP00000043383}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000043383};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [4] {ECO:0000313|Ensembl:ENSXETP00000043383}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001008015.1, ECO:0000313|RefSeq:XP_012818369.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_012818369.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_012818369.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; BC080893; AAH80893.1; -; mRNA.
DR RefSeq; NP_001008015.1; NM_001008014.1.
DR RefSeq; XP_012818369.1; XM_012962915.3.
DR STRING; 8364.ENSXETP00000043383; -.
DR DNASU; 493377; -.
DR Ensembl; ENSXETT00000043383; ENSXETP00000043383; ENSXETG00000020089.
DR GeneID; 493377; -.
DR KEGG; xtr:493377; -.
DR AGR; Xenbase:XB-GENE-954771; -.
DR CTD; 11342; -.
DR Xenbase; XB-GENE-954771; rnf13.
DR eggNOG; KOG4628; Eukaryota.
DR HOGENOM; CLU_035275_1_1_1; -.
DR OMA; GHIVLIP; -.
DR OrthoDB; 5474929at2759; -.
DR TreeFam; TF317486; -.
DR Reactome; R-XTR-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR Proteomes; UP000008143; Chromosome 5.
DR Bgee; ENSXETG00000020089; Expressed in heart and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd02123; PA_C_RZF_like; 1.
DR CDD; cd16796; RING-H2_RNF13; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR044744; ZNRF4/RNF13/RNF167_PA.
DR PANTHER; PTHR46539; E3 UBIQUITIN-PROTEIN LIGASE ATL42; 1.
DR PANTHER; PTHR46539:SF25; RING FINGER PROTEIN 150; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..383
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001008015.1"
FT /id="PRO_5033206044"
FT TRANSMEM 183..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 241..283
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 285..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..358
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 383 AA; 43095 MW; 148A88834F879480 CRC64;
MVTFRMCVAL MKPFCNLLAF CSCLAVIHLV PVQADVAAYT ADNVSRTFDD LPARFGYRLP
SDGLKGYIVT AKPENACQPI SPPPLLRDNT SSVFIVLIKR LECNFDLKVL NAQKAGFKAA
VVYNVDSDDL ISMGSNDVDI LKQIDIPSVF IGESSARFLK EEFSWEKGGY IVLVPDLTLP
LEYYLIPFLI IVGICLVLIV IFMITKFVQD RHRARRNRLR KDQLKKLPIH KFKKGDEYDV
CAVCLDEYEE GDKLRILPCS HAYHCKCVDP WLTKTKKTCP VCKQKVVPSQ GDSESDSDSS
QEDNEVSENT PLLRPMASAS TQSFGAISES HSQQNMMESS GEDEDDDDDE DDSDSSDEEH
NTESVVVQLQ HNMERESRER NTV
//
