ID Q66PH5_ASTMX Unreviewed; 162 AA.
AC Q66PH5;
DT 11-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Distal-less homeobox gene 3b {ECO:0000313|EMBL:AAU04947.1};
DE Flags: Fragment;
GN Name=dlx3b {ECO:0000313|EMBL:AAU04947.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|EMBL:AAU04947.1};
RN [1] {ECO:0000313|EMBL:AAU04947.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15483612; DOI=10.1038/nature02864;
RA Yamamoto Y., Stock D.W., Jeffery W.R.;
RT "Hedgehog signalling controls eye degeneration in blind cavefish.";
RL Nature 431:844-847(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the distal-less homeobox family.
CC {ECO:0000256|ARBA:ARBA00007916}.
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DR EMBL; AY661432; AAU04947.1; -; mRNA.
DR AlphaFoldDB; Q66PH5; -.
DR HOGENOM; CLU_074733_1_0_1; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0043009; P:chordate embryonic development; IEA:UniProt.
DR GO; GO:0048598; P:embryonic morphogenesis; IEA:UniProt.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR022135; Distal-less_N.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR PANTHER; PTHR24327; HOMEOBOX PROTEIN; 1.
DR PANTHER; PTHR24327:SF28; HOMEOBOX PROTEIN DLX-3; 1.
DR Pfam; PF12413; DLL_N; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}.
FT DOMAIN 87..147
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 89..148
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAU04947.1"
FT NON_TER 162
FT /evidence="ECO:0000313|EMBL:AAU04947.1"
SQ SEQUENCE 162 AA; 18788 MW; 63EFBF978B39A83C CRC64;
ESTATDMGYY SDYYSGQPYQ SQPMTSYPQF NMSSMGPAGH YPSKTEYPYS PSYRQYGHYG
RELQSPPHNT VKEEVETEVR MVNGKPKKIR KPRTIYSSFQ LAALQRRFQK AQYLALPERA
ELAAQLGLTQ TQVKIWFQNR RSKFKKLYKN GEIPLEHSPN AS
//
