ID Q673F7_TRYCR Unreviewed; 3474 AA.
AC Q673F7;
DT 11-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2004, sequence version 1.
DT 24-JAN-2024, entry version 64.
DE SubName: Full=Dispersed gene family protein 1 (DGF-1) {ECO:0000313|EMBL:PWV20359.1};
DE SubName: Full=Putative surface protein {ECO:0000313|EMBL:AAT77681.1};
GN Name=DGF-1 {ECO:0000313|EMBL:AAT77681.1};
GN ORFNames=C3747_6g697 {ECO:0000313|EMBL:PWV20359.1};
OS Trypanosoma cruzi.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=5693 {ECO:0000313|EMBL:AAT77681.1};
RN [1] {ECO:0000313|EMBL:AAT77681.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CL Brener {ECO:0000313|EMBL:AAT77681.1};
RX PubMed=12234681; DOI=10.1016/S0378-1119(02)00768-0;
RA Chiurillo M.A., Santos M.R., Franco Da Silveira J., Ramirez J.L.;
RT "An improved general approach for cloning and characterizing telomeres: the
RT protozoan parasite Trypanosoma cruzi as model organism.";
RL Gene 294:197-204(2002).
RN [2] {ECO:0000313|EMBL:AAT77681.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CL Brener {ECO:0000313|EMBL:AAT77681.1};
RX PubMed=15716016; DOI=10.1016/j.gene.2004.10.014;
RA Kim D., Chiurillo M.A., El-Sayed N., Jones K., Santos M.R., Porcile P.E.,
RA Andersson B., Myler P., da Silveira J.F., Ramirez J.L.;
RT "Telomere and subtelomere of Trypanosoma cruzi chromosomes are enriched in
RT (pseudo)genes of retrotransposon hot spot and trans-sialidase-like gene
RT families: the origins of T. cruzi telomeres.";
RL Gene 346:153-161(2005).
RN [3] {ECO:0000313|EMBL:PWV20359.1, ECO:0000313|Proteomes:UP000246078}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TCC {ECO:0000313|EMBL:PWV20359.1,
RC ECO:0000313|Proteomes:UP000246078};
RX PubMed=29708484;
RA Berna L., Rodriguez M., Chiribao M.L., Parodi-Talice A., Pita S., Rijo G.,
RA Alvarez-Valin F., Robello C.;
RT "Expanding an expanded genome: long-read sequencing of Trypanosoma cruzi.";
RL Microb. Genom. 0:0-0(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AY551440; AAT77681.1; -; Genomic_DNA.
DR EMBL; PRFC01000006; PWV20359.1; -; Genomic_DNA.
DR VEuPathDB; TriTrypDB:BCY84_02596; -.
DR VEuPathDB; TriTrypDB:C3747_6g697; -.
DR VEuPathDB; TriTrypDB:C4B63_68g83; -.
DR VEuPathDB; TriTrypDB:ECC02_000736; -.
DR VEuPathDB; TriTrypDB:Tc_MARK_3381; -.
DR VEuPathDB; TriTrypDB:TcBrA4_0119650; -.
DR VEuPathDB; TriTrypDB:TcCL_ESM06837; -.
DR VEuPathDB; TriTrypDB:TcCL_ESM08318; -.
DR VEuPathDB; TriTrypDB:TcCLB.504313.30; -.
DR VEuPathDB; TriTrypDB:TcCLB.507477.10; -.
DR VEuPathDB; TriTrypDB:TcCLB.510355.10; -.
DR VEuPathDB; TriTrypDB:TCDM_10833; -.
DR VEuPathDB; TriTrypDB:TcG_09381; -.
DR VEuPathDB; TriTrypDB:TCSYLVIO_000611; -.
DR VEuPathDB; TriTrypDB:TCSYLVIO_000647; -.
DR VEuPathDB; TriTrypDB:TCSYLVIO_000652; -.
DR VEuPathDB; TriTrypDB:TCSYLVIO_006438; -.
DR VEuPathDB; TriTrypDB:TCSYLVIO_008701; -.
DR VEuPathDB; TriTrypDB:TCSYLVIO_009449; -.
DR VEuPathDB; TriTrypDB:TCSYLVIO_010290; -.
DR VEuPathDB; TriTrypDB:TCSYLVIO_011054; -.
DR VEuPathDB; TriTrypDB:TcYC6_0172570; -.
DR Proteomes; UP000246078; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR021053; Dispersed_gene_fam_prot1_C.
DR InterPro; IPR021004; Dispersed_gene_fam_prot1_dom4.
DR InterPro; IPR021282; Dispersed_gene_fam_prot1_dom5.
DR InterPro; IPR006626; PbH1.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR PANTHER; PTHR24044:SF420; DELTA AND NOTCH-LIKE EPIDERMAL GROWTH FACTOR-RELATED RECEPTOR ISOFORM X1; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF11024; DGF-1_4; 1.
DR Pfam; PF11038; DGF-1_5; 1.
DR Pfam; PF11040; DGF-1_C; 1.
DR SMART; SM00710; PbH1; 12.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR SUPFAM; SSF51126; Pectin lyase-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3058..3084
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3129..3146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3166..3191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3197..3218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3267..3289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3295..3314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3321..3343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3355..3380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2840..2916
FT /note="Dispersed gene family protein 1"
FT /evidence="ECO:0000259|Pfam:PF11024"
FT DOMAIN 2929..3206
FT /note="Dispersed gene family protein 1"
FT /evidence="ECO:0000259|Pfam:PF11038"
FT DOMAIN 3378..3463
FT /note="Dispersed gene family protein 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF11040"
FT REGION 2857..2879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3399..3448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3399..3414
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3416..3433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3474 AA; 359643 MW; 44DB85D4E91B9CBE CRC64;
MCLCLWMWSF VGACPRSRHR VRRRAIAAVR AALVVVLALV AVAAWMPAVH AVVLRLRGGT
VDRAITVGRA VDTVLMDGVS ITNGVAVVFD VAAMLPGTLR IELRNCVCDG GAQLYVRGYS
GEPASDRSLE VSVSGLSGGY CSLVFVHNLP AHTNVSVRDS TIVTPGPMRY SQLSGLTDAV
ASPLVLHATS LLQTQLRVSS TVLRSLHAGG SAVHVGGGVD LLSSAVVLDG VLLEASGGPT
AFAMHVASSS RLSLRSHSVF SVTNVSVVSS GGGIVLGGRL AVSDSVLRFV GVEGSVASSL
VRCDGGTVGG GGWLDLHDVW AVGAASSVAS LSGVTLSGGA VSIARCTATG ATLVSEPAIT
SGAVSVQCNR AGGRVLQSSG EYRLAGLPSV SVVPCDGCAA ALACFDALTA SFSDCACSCR
AGGVGEACLP FDVPPARVGG GGGGAQGCVS GVTLTESVTV GGGRATACFD SVVLSGPITV
AVDLRSMDAF ADALNVTLRH CVLAGGAQLR IGGLSESTAR PMPHALVNMT NVTSLEGTIV
LQGTMPPNSS VLLANSTLRA TVGGSQYVPT TPGHEESRYG PALVLDGVRL LSTRFVMTRS
TLVCGGGSCA AIVVERGFVV NLSSVFYMDN CAVVSQMHVM YAFASDLRVS GGSVFSIQNS
SWSAPSIGFY EGACVFEDVA VDGGSVLQIV FSTFRLGFAM LTAATLTVTG GGWLVHRNNE
FRTAYVVYVV NENGVAFHDR SVWSILDNNF TYGSYSSTIA HMTSNWSPPS DTRPIIYGMC
NEAMGSPVTN YGVDLNIGAP VRVLDCGACT VDAVCFAART SSIIGCECVC AAGGHGDACL
PAAVPDGLGP LPLSDADDTE VRCVHGGSVS SVYDPDPGVR GLCFVNVTFT AAILLDLWSF
DASQQTLNIT LLQCVLMGLS VRGSGARVHV NVTSSFLDSG ALEFEGDFGV SSQILVAGSA
ILTTSVHTIG FLDFYPGVNS TLLLLDNYIE GSSFAVCFSN TVVVVDGGGI IVKGNTLRAT
EEDYGVESSV YVYSVAVKNS GYLNVENNKM RAVNGVYFYG DTTVSSAGLL RVADCTFVES
TEVFESALVH LDGSVTLEGG AQWRVEGNNV SALSILSIAH AHQKIQLSGS GTTVALAHNR
QVDLRASFVN IFPSSIVVTS SAQFVVGCNL QDDEEVSYDD LFSEEVVVFG CGTCNDDAAC
YMPGTESVDR GSCSCSCKDG WHGASCLPFE VPNTVVPPVA ERAVDGDTSC VVNQTLTKVT
LNMWKTHHCY VGVTFSGVGA ALTFFLNSMP LHLPINITLS GCTFREGAAL QFVGGAEVAE
SAGVLIRVSQ TVMRSSVVIF ALALPQHCDI AVTEVDAVQS SAVQLLDTRI NMLSVVMLDD
VVLSASTLLV SNVKAHASRR GGFGLYSTGT LMVVGGSSLY ARYCSLDGYT HLFQLNILSV
RDHSVLALLN NTMASGTSLL YQQQDFSVSE HSVLRVVGNS GSVSYAIFAE GSWTVQQSSW
LDWRDNDVGL GAIFKVWDSA FVSIDSSSVV TLTGCKMGST GLSGPLRSLV EASYLFVAGC
LTVAGRVVTT AAELELNGIT NVTTIAACGE CTKEGDCFAP LTTAVIDCNC QCAAGGHGDV
CVPAPVPAGP PPPPPPPPPP PPPPVGECIS DMVYPEVAQA VGSGLSWLCY RNVTFSGGGM
SLTVLIGAMT GDVANITFDG CTWRDGAVLV LLGNAHAAVE SLNIVVTGNT FRDALLSPEG
GFPPHTNITI SGNRFTVTRL IPRTGLGLDS PSCVAMNGLV ISNDSAVVLS GNVFQTVTAS
SSAIHVVDSA LRVSWSSLFA VVGNTFHMDG GDTTLINLEG SSDSLSLSVL NNSAVVIRGN
LVSSQVQYVI FFRWALSVES QSAVVFQGND MQRSVAVFYS TFSSYIYYHS WLQLGGNLCR
ESPSDAFAVL SLTVNLRDST VSVSGNRFMS GKDTPKALWI YSGPSDLTNG VILAACNTVN
GEEEANYVIP SVYNATILTC SDPCTLLASC FPAYTTTAPS DGCACTCAEG GHGDACLPVA
VPEPPSTDGA DWCVRDVRVG VEVSAGFGTS VACYVGVTFA ADVVVDMESM SGSVRNVTLA
NCTFLGRASL YVVGWRSDPP AGERVDVLIS GLESRSGGGV MVANQFPPGS RVTVVDSVLI
AENRFAYRGA YGLGDASACL VVHKVNLTGS VLTIARTHVA AVFRDAVGVL FVGGVALSSR
GALYVDGLLV QTALGLCVSV EGGVAASGGS VVAFVDSDFL LCKHAVTVRG AVSVSGSVVA
FVRSDFASAE DYAVAFDSTV SLAGGSMLLA KGNVHDGVSR EMLYAAGAVT AVGSTLSFVR
NRALLPRMLS LSLSLAAGAH LRVACNDAGG RVLSTAEEYA AAGFGDAGSI DVVGCDACDR
DTYCYAPGTA SAGMRNGVCV CACGSGGYGE ACVAVGAPAL PPAVGTASSV FVREGVPLQS
VFVVPAGASE VTLRHVVLDG VSPVLHVPWM ARDGVRIVVQ NVSLLNGAVL YVMGGGALRG
AVAAGSDESG PVELSVCDVE ALNGALVLTG TFPAGSVLTV TDSLLVAARP TPLVYLPGSQ
SSPYAPLLVL SGLRLVRSVL VVSGVALVTV VTGGRTVVVD GAVLELVGGG VALDAAVLGG
DYALYASARV VASGGAVLRV SGSQVYAAHG LVFESGVAAN ASAVVVNDNA GALTDGALLV
LRGSASFASG SWLSVRGNSI SGRLLSVPSY PRSAEFAQST LTLHGNAGSG SVVMDGTVAL
GGDGRRFVVG CLTLNGQALR PMEYRSAGII GEFRPVACGV CDADVHCFGA ATRAMSGSCG
CRCAEGGYGR DCLPVYLPHV DGCNRTHAIP PLSHTATLTE TRSPTPTWTP KPSLSTAHYS
PTQYGSTETL QVTETVVLPS TRTPTASVSS TLWWSDVACP TLAVTTTAAG GSLTQNDIRG
GGSAVPTRLM VALPPPFRWA SDPQLGTHLS FVPVSTAQPR GFGGPWGAML RNATWVRNAM
NPSTVLELAV PVHCGYFIAA DETIVIRCDA VAVFGGCRGV LLGSFTIRSN TLPAAASVLS
AITGVVAGAA AVAVVVTGGL GSILELQALG VFARMPCASA QERASTVALP YFLSVFAALD
PLWMVVGNAL LAAVFGCVHC GVTAAFQRWR GVDAASAWAA MRFPSLTYVV AHAMHLGIFF
GSVLALAMPG ARVQHRVIGV VGVLYGVAFP AGVCYLIARH TGASFTRYWQ FSRKPLHERL
LYPVGYWHPA AQQRMYGGML TNMRGSYVYW CVFQLSVLCV VCLIAAVQSP VGGCHVQYFC
MAAVLLAGAG VVAFTNMMRS AFVTVMQTAS FVLLAALCLI SAANHLAPSD GGARAYVAIV
LLLTAVLLAV TVYSVVVWYA EDRHWQELRE PRRGGLETLL RDDEGSDEDA QKPHDMTSVS
YASGTTVASS YRPPAQLQPM AGDTRSDTLS LFDRAPDANC SINYAPLDRW RSSA
//