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Database: UniProt
Entry: Q67T37
LinkDB: Q67T37
Original site: Q67T37 
ID   UVRC_SYMTH              Reviewed;         629 AA.
AC   Q67T37;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   14-MAY-2014, entry version 68.
DE   RecName: Full=UvrABC system protein C;
DE            Short=Protein UvrC;
DE   AltName: Full=Excinuclease ABC subunit C;
GN   Name=uvrC; OrderedLocusNames=STH171;
OS   Symbiobacterium thermophilum (strain T / IAM 14863).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales;
OC   Clostridiales Family XVIII. Incertae Sedis; Symbiobacterium.
OX   NCBI_TaxID=292459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T / IAM 14863;
RX   PubMed=15383646; DOI=10.1093/nar/gkh830;
RA   Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T.,
RA   Morimura K., Ikeda H., Hattori M., Beppu T.;
RT   "Genome sequence of Symbiobacterium thermophilum, an uncultivable
RT   bacterium that depends on microbial commensalism.";
RL   Nucleic Acids Res. 32:4937-4944(2004).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides
CC       of the lesion. The N-terminal half is responsible for the 3'
CC       incision and the C-terminal half is responsible for the 5'
CC       incision (By similarity).
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the UvrC family.
CC   -!- SIMILARITY: Contains 1 GIY-YIG domain.
CC   -!- SIMILARITY: Contains 1 UVR domain.
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DR   EMBL; AP006840; BAD39156.1; -; Genomic_DNA.
DR   RefSeq; YP_074000.1; NC_006177.1.
DR   ProteinModelPortal; Q67T37; -.
DR   STRING; 292459.STH171; -.
DR   EnsemblBacteria; BAD39156; BAD39156; STH171.
DR   GeneID; 2980383; -.
DR   KEGG; sth:STH171; -.
DR   PATRIC; 23778401; VBISymThe116959_0172.
DR   eggNOG; COG0322; -.
DR   HOGENOM; HOG000279960; -.
DR   KO; K03703; -.
DR   OMA; QTIASCV; -.
DR   OrthoDB; EOG6K13R9; -.
DR   BioCyc; STHE292459:GJMM-187-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   Gene3D; 4.10.860.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR027299; GIY-YIG_dom.
DR   InterPro; IPR000305; GIY-YIG_SF.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_homol_region.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; DNA damage; DNA excision; DNA repair;
KW   Excision nuclease; SOS response.
FT   CHAIN         1    629       UvrABC system protein C.
FT                                /FTId=PRO_0000227483.
FT   DOMAIN       12     91       GIY-YIG.
FT   DOMAIN      200    235       UVR.
SQ   SEQUENCE   629 AA;  71995 MW;  C2440ADA97467B76 CRC64;
     MGLEEQLRLL PDRPGCYLFK DASGRIIYVG KARNLKNRVR QYFQSSRNLT AKVLAMVGQI
     VEIEHIVTDT ETEALVLESN LIKKHKPKYN IRLRDDKHYP YLRLTLTEQW PRLVVARSMK
     KDGSRYFGPY TSSQAMWETM KLARRLFPLR TCNDPSRYPR GCLQYHIGRC LGPCLPDFDR
     HREYAEAVRD LQAFLEGRTQ EVLERLRARM EQAAERLEFE RAAELRDQIR AIEKVTEKQK
     IIAHTMVDLD VIAYARLYDE AGVQVFFVRQ GKLVGRDQFL MSGADEMTGG EILAAFIQQH
     YSQTDFVPKE ILVSEDLPDA DVIAEWLSAK RGSRVALRCP KRGEKRALVE MVAQNAQEAM
     TERRQQRELE LAATEGVLRE LQAYLDLPRL PHRIECFDVS HVQGAEVVAS MVVFEGGRPK
     KSDYRRFKMK VDQNNDFANM AEAVGRRFRR GLAERAAQVE GRVRDLEEGR VAEGGAEYGG
     KFADFPDLLI IDGGKGQLSY ARAVMRELGV DHIPTFGLAK ENELLCTEDR PDWIELPRGS
     QALFLLQRIR DEAHRFAITY HRKLHRRAST HSRLDDVPGI GPKRKKALLQ HFGSLKAIRE
     ASVEEVAQVP GITLELAERV KEALGGPMR
//
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