ID UVRC_SYMTH Reviewed; 629 AA.
AC Q67T37;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 29-MAY-2013, entry version 63.
DE RecName: Full=UvrABC system protein C;
DE Short=Protein UvrC;
DE AltName: Full=Excinuclease ABC subunit C;
GN Name=uvrC; OrderedLocusNames=STH171;
OS Symbiobacterium thermophilum (strain T / IAM 14863).
OC Bacteria; Firmicutes; Clostridia; Clostridiales;
OC Clostridiales Family XVIII. Incertae Sedis; Symbiobacterium.
OX NCBI_TaxID=292459;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T / IAM 14863;
RX PubMed=15383646; DOI=10.1093/nar/gkh830;
RA Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T.,
RA Morimura K., Ikeda H., Hattori M., Beppu T.;
RT "Genome sequence of Symbiobacterium thermophilum, an uncultivable
RT bacterium that depends on microbial commensalism.";
RL Nucleic Acids Res. 32:4937-4944(2004).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides
CC of the lesion. The N-terminal half is responsible for the 3'
CC incision and the C-terminal half is responsible for the 5'
CC incision (By similarity).
CC -!- SUBUNIT: Interacts with UvrB in an incision complex (By
CC similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the UvrC family.
CC -!- SIMILARITY: Contains 1 GIY-YIG domain.
CC -!- SIMILARITY: Contains 1 UVR domain.
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DR EMBL; AP006840; BAD39156.1; -; Genomic_DNA.
DR RefSeq; YP_074000.1; NC_006177.1.
DR ProteinModelPortal; Q67T37; -.
DR STRING; 292459.STH171; -.
DR EnsemblBacteria; BAD39156; BAD39156; STH171.
DR GeneID; 2980383; -.
DR KEGG; sth:STH171; -.
DR PATRIC; 23778401; VBISymThe116959_0172.
DR eggNOG; COG0322; -.
DR HOGENOM; HOG000279960; -.
DR KO; K03703; -.
DR OMA; QKLFPIR; -.
DR ProtClustDB; PRK00558; -.
DR BioCyc; STHE292459:GJMM-187-MONOMER; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:HAMAP.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:HAMAP.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:HAMAP.
DR GO; GO:0009432; P:SOS response; IEA:HAMAP.
DR Gene3D; 3.40.1440.10; -; 1.
DR Gene3D; 4.10.860.10; -; 1.
DR HAMAP; MF_00203; UvrC; 1; -.
DR InterPro; IPR027299; GIY-YIG_dom.
DR InterPro; IPR000305; GIY-YIG_SF.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_homol_region.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_HhH_N; 1.
DR SMART; SM00465; GIYc; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF47781; RuvA_2_like; 1.
DR SUPFAM; SSF46600; UvrB_C; 1.
DR SUPFAM; SSF82771; UvrC_N; 1.
DR TIGRFAMs; TIGR00194; uvrC; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; DNA damage; DNA excision; DNA repair;
KW Excision nuclease; SOS response.
FT CHAIN 1 629 UvrABC system protein C.
FT /FTId=PRO_0000227483.
FT DOMAIN 12 91 GIY-YIG.
FT DOMAIN 200 235 UVR.
SQ SEQUENCE 629 AA; 71995 MW; C2440ADA97467B76 CRC64;
MGLEEQLRLL PDRPGCYLFK DASGRIIYVG KARNLKNRVR QYFQSSRNLT AKVLAMVGQI
VEIEHIVTDT ETEALVLESN LIKKHKPKYN IRLRDDKHYP YLRLTLTEQW PRLVVARSMK
KDGSRYFGPY TSSQAMWETM KLARRLFPLR TCNDPSRYPR GCLQYHIGRC LGPCLPDFDR
HREYAEAVRD LQAFLEGRTQ EVLERLRARM EQAAERLEFE RAAELRDQIR AIEKVTEKQK
IIAHTMVDLD VIAYARLYDE AGVQVFFVRQ GKLVGRDQFL MSGADEMTGG EILAAFIQQH
YSQTDFVPKE ILVSEDLPDA DVIAEWLSAK RGSRVALRCP KRGEKRALVE MVAQNAQEAM
TERRQQRELE LAATEGVLRE LQAYLDLPRL PHRIECFDVS HVQGAEVVAS MVVFEGGRPK
KSDYRRFKMK VDQNNDFANM AEAVGRRFRR GLAERAAQVE GRVRDLEEGR VAEGGAEYGG
KFADFPDLLI IDGGKGQLSY ARAVMRELGV DHIPTFGLAK ENELLCTEDR PDWIELPRGS
QALFLLQRIR DEAHRFAITY HRKLHRRAST HSRLDDVPGI GPKRKKALLQ HFGSLKAIRE
ASVEEVAQVP GITLELAERV KEALGGPMR
//
